SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 10 LEU A 134
ALA A 129
LEU A 125
LEU A 119
ARG A  27
 None
 1.42A 1pcgB-1cw0A:
undetectable		 1pcgB-1cw0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 10 LEU A 134
ALA A 129
LEU A 125
LEU A 119
ARG A  27
 None
 1.48A 1qktA-1cw0A:
undetectable		 1qktA-1cw0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 11 PRO A  47
ARG A  99
VAL A 111
GLY A 140
GLU A 136
 None
 1.47A 2h9tH-1cw0A:
undetectable		 2h9tH-1cw0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		4 / 7 VAL A 114
THR A  63
ARG A 120
LYS A 124
 None
MG  A 203 (-4.7A)
None
None
 1.08A 2kotA-1cw0A:
undetectable		 2kotA-1cw0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		3 / 3 CYH A  73
HIS A  72
PHE A  76
 ZN  A 201 (-2.3A)
None
None
 0.89A 3cr4X-1cw0A:
undetectable		 3cr4X-1cw0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		3 / 3 LEU A 107
LEU A 104
ARG A  99
 None
 0.71A 3hcnB-1cw0A:
undetectable		 3hcnB-1cw0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		4 / 7 GLU A 132
GLU A 136
GLY A 151
ARG A 133
 None
 0.99A 4fgzA-1cw0A:
undetectable		 4fgzA-1cw0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		4 / 5 SER A  11
LYS A  12
ARG A  10
ASP A   6
 None
 1.43A 4xdtA-1cw0A:
0.0		 4xdtA-1cw0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 10 LEU A 134
ALA A 129
LEU A 125
LEU A 119
ARG A  27
 None
 1.46A 5dxeB-1cw0A:
undetectable		 5dxeB-1cw0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 10 LEU A 134
ALA A 129
LEU A 125
LEU A 119
ARG A  27
 None
 1.42A 5hyrA-1cw0A:
undetectable		 5hyrA-1cw0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		4 / 7 GLY A  48
VAL A 111
ILE A  61
VAL A  60
 None
 0.77A 5ik1A-1cw0A:
undetectable		 5ik1A-1cw0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1cw0 PROTEIN (DNA
MISMATCH
ENDONUCLEASE)
(Escherichia
coli) 		5 / 11 ILE A  61
ALA A 118
LEU A 130
GLY A 151
ALA A 145
 None
 1.30A 6ieyA-1cw0A:
1.9
6ieyB-1cw0A:
1.0		 6ieyA-1cw0A:
18.35
6ieyB-1cw0A:
18.35