SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 ALA A  24
LEU A 137
LEU A 169
ALA A  90
 None
NAD  A 501 (-3.9A)
None
NAD  A 501 (-3.9A)
 0.80A 1e7cA-1cwuA:
undetectable		 1e7cA-1cwuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 ALA A 272
ILE A 226
LEU A 133
LEU A 186
LEU A  40
 None
None
None
NAD  A 501 (-3.6A)
None
 1.23A 1eiiA-1cwuA:
0.0		 1eiiA-1cwuA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 SER A 151
SER A 163
ALA A 158
ILE A 159
 None
 1.11A 1gm7A-1cwuA:
0.0
1gm7B-1cwuA:
0.0		 1gm7A-1cwuA:
22.44
1gm7B-1cwuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifA-1cwuA:
4.6		 1kifA-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifB-1cwuA:
4.7		 1kifB-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifC-1cwuA:
4.7		 1kifC-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifD-1cwuA:
4.7		 1kifD-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifE-1cwuA:
4.7		 1kifE-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifF-1cwuA:
4.6		 1kifF-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifG-1cwuA:
4.7		 1kifG-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifH-1cwuA:
4.7		 1kifH-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 LEU A 186
LEU A 137
ALA A 157
ALA A 161
LEU A 209
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.9A)
None
NAD  A 501 ( 4.7A)
None
 1.18A 1kt5A-1cwuA:
0.0		 1kt5A-1cwuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 4 ALA A 119
VAL A 123
ALA A 120
HIS A 172
 None
 1.22A 1q23F-1cwuA:
0.0		 1q23F-1cwuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 4 VAL A 116
ALA A 120
LEU A 133
PHE A  22
 None
 1.25A 1q97B-1cwuA:
undetectable		 1q97B-1cwuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.09A 1ve9A-1cwuA:
4.6		 1ve9A-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 TYR A 198
PHE A 246
ALA A 240
MET A 250
 TDB  A 502 (-4.5A)
None
TDB  A 502 ( 3.1A)
None
 1.04A 1x8vA-1cwuA:
undetectable		 1x8vA-1cwuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.12A 2du8G-1cwuA:
4.7		 2du8G-1cwuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.13A 2du8J-1cwuA:
4.6		 2du8J-1cwuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 9 ALA A 207
ALA A 205
GLY A 199
SER A 191
ALA A 190
 None
 1.28A 2vh3A-1cwuA:
undetectable		 2vh3A-1cwuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 ALA A 233
TYR A  32
ILE A 231
HIS A 135
 NAD  A 501 (-3.6A)
None
None
None
 1.00A 2zm8A-1cwuA:
0.0		 2zm8A-1cwuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 ALA A 233
TYR A  32
ILE A 231
HIS A 135
 NAD  A 501 (-3.6A)
None
None
None
 1.00A 2zmaA-1cwuA:
0.0		 2zmaA-1cwuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 6 THR A 288
THR A 230
LEU A 209
THR A 187
 None
 0.96A 3deuB-1cwuA:
0.0		 3deuB-1cwuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 ALA A 258
LEU A 264
GLY A 234
THR A 288
 None
 0.92A 3dl9A-1cwuA:
0.0		 3dl9A-1cwuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 8 THR A 150
LEU A 147
SER A 203
ASN A 139
 None
 1.00A 3kp2A-1cwuA:
0.0
3kp2B-1cwuA:
0.0		 3kp2A-1cwuA:
21.32
3kp2B-1cwuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 11 LEU A 186
ILE A 231
ALA A 266
ALA A  37
ALA A 273
 NAD  A 501 (-3.6A)
None
None
None
None
 1.12A 3mdtB-1cwuA:
0.0		 3mdtB-1cwuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 9 SER A 204
ALA A 207
GLU A 210
ILE A 194
 None
 0.51A 4xtaA-1cwuA:
undetectable		 4xtaA-1cwuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 5 GLY A 234
TYR A 253
SER A 254
ASP A 292
 None
 1.16A 4xueA-1cwuA:
6.8		 4xueA-1cwuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 GLY A 234
TYR A 253
SER A 254
ASP A 292
ALA A 233
 None
None
None
None
NAD  A 501 (-3.6A)
 1.19A 4ymgB-1cwuA:
9.0		 4ymgB-1cwuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 GLY A 234
TYR A 253
SER A 254
SER A 238
ALA A 233
 None
None
None
NAD  A 501 (-2.5A)
NAD  A 501 (-3.6A)
 1.21A 4ymgB-1cwuA:
9.0		 4ymgB-1cwuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		4 / 6 ILE A 176
MET A 177
ASN A 178
ASP A 131
 None
 0.96A 6dhbA-1cwuA:
undetectable		 6dhbA-1cwuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 LEU A 137
GLY A  25
VAL A 134
LEU A 133
ILE A 132
 NAD  A 501 (-3.9A)
NAD  A 501 (-3.5A)
None
None
None
 0.98A 6ectA-1cwuA:
3.5		 6ectA-1cwuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1cwu ENOYL ACP REDUCTASE
(Brassica
napus) 		5 / 12 LEU A 137
GLY A  25
VAL A 134
LEU A 133
ILE A 132
 NAD  A 501 (-3.9A)
NAD  A 501 (-3.5A)
None
None
None
 0.96A 6ecxA-1cwuA:
3.9		 6ecxA-1cwuA:
22.06