SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_B_SAMB300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	1cxa	CYTOCHROME C2 (Rhodobacter sphaeroides)	5 / 12	LEU A 87 TYR A 90 ALA A 48 TRP A 71 HIS A 75	None None HEM A 126 (-4.4A) HEM A 126 (-4.0A) None	1.03A	3ou6B-1cxaA: undetectable	3ou6B-1cxaA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	1cxa	CYTOCHROME C2 (Rhodobacter sphaeroides)	5 / 12	LEU A 87 TYR A 90 ALA A 48 TRP A 71 HIS A 75	None None HEM A 126 (-4.4A) HEM A 126 (-4.0A) None	1.05A	3ou7C-1cxaA: undetectable	3ou7C-1cxaA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_D_ACTD4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	1cxa	CYTOCHROME C2 (Rhodobacter sphaeroides)	4 / 5	LEU A 87 LEU A 69 GLY A 65 THR A 91	None	0.81A	3si7C-1cxaA: 0.0 3si7D-1cxaA: 0.0	3si7C-1cxaA: 17.89 3si7D-1cxaA: 17.89