SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 11 ALA A 417
LEU A 459
LEU A 261
ALA A 224
THR A 226
 None
 1.31A 1tz8A-1cy9A:
0.0
1tz8B-1cy9A:
0.0		 1tz8A-1cy9A:
18.25
1tz8B-1cy9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.83A 2aw1A-1cy9A:
0.0		 2aw1A-1cy9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 VAL A 268
VAL A 415
LEU A 234
THR A 226
 None
 0.85A 2gehA-1cy9A:
undetectable		 2gehA-1cy9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 4 GLY A 315
LEU A 289
PHE A 284
ILE A 394
 None
 0.96A 4xv2A-1cy9A:
undetectable		 4xv2A-1cy9A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		5 / 12 ASN A 326
GLN A 402
THR A 288
GLY A 281
GLN A 354
 None
 1.27A 5oj0A-1cy9A:
undetectable		 5oj0A-1cy9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		4 / 8 VAL A 268
VAL A 415
LEU A 234
THR A 226
 None
 0.75A 5tt3F-1cy9A:
undetectable		 5tt3F-1cy9A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cy9 DNA TOPOISOMERASE I
(Escherichia
coli) 		3 / 3 LYS A 365
ASN A 326
SER A 357
 None
 1.13A 5yw0A-1cy9A:
0.0		 5yw0A-1cy9A:
24.17