SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 12 VAL A 138
TYR A 241
PRO A 144
SER A 191
PHE A 196
 IPA  A 246 ( 4.8A)
None
None
None
None
 1.44A 1fdsA-1cydA:
27.4		 1fdsA-1cydA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		4 / 4 LEU A   8
LEU A 223
SER A 224
LEU A   3
 None
 1.16A 1ya3A-1cydA:
undetectable		 1ya3A-1cydA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 12 GLY A  16
VAL A  24
LEU A  44
LEU A  47
LEU A  61
 NDP  A 245 (-3.7A)
None
None
None
NDP  A 245 (-3.8A)
 1.30A 1ya4B-1cydA:
3.4		 1ya4B-1cydA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		4 / 7 GLY A 154
ALA A 155
MET A 156
LEU A 159
 None
 0.86A 2wekB-1cydA:
9.1		 2wekB-1cydA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		4 / 8 GLN A 113
LEU A  61
ASP A  63
ASP A  65
 None
NDP  A 245 (-3.8A)
None
None
 1.01A 3qj7A-1cydA:
0.0
3qj7D-1cydA:
0.0		 3qj7A-1cydA:
22.33
3qj7D-1cydA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 12 GLY A  14
GLY A  16
VAL A  37
THR A  38
VAL A 106
 NDP  A 245 (-3.0A)
NDP  A 245 (-3.7A)
None
NDP  A 245 (-4.0A)
NDP  A 245 (-4.2A)
 0.98A 4f84A-1cydA:
6.6		 4f84A-1cydA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		4 / 7 VAL A  87
SER A 136
TYR A 149
MET A 186
 None
IPA  A 246 ( 2.7A)
IPA  A 246 ( 4.4A)
NDP  A 245 (-3.6A)
 0.40A 4hxyB-1cydA:
19.2		 4hxyB-1cydA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 9 ALA A  36
ILE A 219
VAL A 216
GLY A  20
ILE A  54
 None
 1.00A 4r21B-1cydA:
0.0		 4r21B-1cydA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		5 / 12 GLY A 168
VAL A 127
ARG A 226
SER A 231
ALA A 228
 None
 1.21A 6c2mB-1cydA:
0.0		 6c2mB-1cydA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 1cyd CARBONYL REDUCTASE
(Mus
musculus) 		3 / 3 LEU A 108
SER A 105
PHE A 104
 None
 0.60A 6fgcA-1cydA:
2.8		 6fgcA-1cydA:
21.85