SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		3 / 3 GLU A  94
LYS A  35
VAL A  37
 None
 0.76A 1l2iA-1cynA:
0.0		 1l2iA-1cynA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 5 PHE A  44
PHE A 120
PHE A  61
VAL A  14
 None
 1.26A 2lh6A-1cynA:
undetectable		 2lh6A-1cynA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 6 PHE A  30
PHE A  44
GLY A  72
GLY A  73
 None
 0.86A 2qr2A-1cynA:
undetectable
2qr2B-1cynA:
0.0		 2qr2A-1cynA:
23.21
2qr2B-1cynA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 5 GLY A  72
GLY A  73
PHE A  30
PHE A  44
 None
 0.81A 2qr2A-1cynA:
0.0
2qr2B-1cynA:
0.0		 2qr2A-1cynA:
23.21
2qr2B-1cynA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 8 PHE A  30
PHE A  44
GLY A  72
GLY A  73
 None
 0.76A 2qx4A-1cynA:
undetectable
2qx4B-1cynA:
undetectable		 2qx4A-1cynA:
23.21
2qx4B-1cynA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 6 PHE A  30
PHE A  44
GLY A  72
GLY A  73
 None
 0.76A 2qx6A-1cynA:
undetectable
2qx6B-1cynA:
undetectable		 2qx6A-1cynA:
23.21
2qx6B-1cynA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		4 / 7 ALA A  48
GLY A  50
ASP A  17
ARG A  27
 None
 0.85A 2uyqA-1cynA:
undetectable		 2uyqA-1cynA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		5 / 11 PHE A  30
ILE A 167
VAL A 165
LEU A  18
VAL A 146
 None
 0.96A 3w67A-1cynA:
undetectable		 3w67A-1cynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		5 / 12 ARG A  77
ARG A  90
GLY A  83
ALA A 111
GLN A 119
 None
 1.25A 4ryaA-1cynA:
0.0		 4ryaA-1cynA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B
(Homo
sapiens) 		5 / 10 PRO A  92
ALA A 109
GLY A  80
THR A  81
ALA A 111
 None
 1.33A 5vyhA-1cynA:
undetectable		 5vyhA-1cynA:
20.70