SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.39A 2iwkA-1cyxA:
0.1		 2iwkA-1cyxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.29A 2iwkA-1cyxA:
0.1		 2iwkA-1cyxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.39A 2iwkB-1cyxA:
0.1		 2iwkB-1cyxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.29A 2iwkB-1cyxA:
0.1		 2iwkB-1cyxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1cyx CYOA
(Escherichia
coli) 		4 / 8 HIS A 172
SER A 167
ASP A 135
ALA A 187
 CUA  A 316 (-2.9A)
None
None
None
 1.14A 2rk8A-1cyxA:
undetectable		 2rk8A-1cyxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1cyx CYOA
(Escherichia
coli) 		5 / 10 GLY A 205
ALA A 208
PHE A 174
PHE A 163
LEU A 193
 None
 1.39A 3a3yA-1cyxA:
undetectable		 3a3yA-1cyxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.38A 3dtuB-1cyxA:
14.4		 3dtuB-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.26A 3dtuB-1cyxA:
14.4		 3dtuB-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.23A 3dtuD-1cyxA:
13.4		 3dtuD-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.37A 3dtuD-1cyxA:
13.4		 3dtuD-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1cyx CYOA
(Escherichia
coli) 		5 / 12 SER A 181
LEU A 193
VAL A 161
ALA A 222
PHE A 155
 None
 1.34A 3nuvA-1cyxA:
0.0		 3nuvA-1cyxA:
22.55