SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
 0.81A 1ao8A-1cz3A:
17.9		 1ao8A-1cz3A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ASP A  27
PHE A  31
THR A  47
LEU A  55
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
 0.86A 1ao8A-1cz3A:
17.9		 1ao8A-1cz3A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.53A 1cd2A-1cz3A:
16.7		 1cd2A-1cz3A:
28.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
GLU A  50
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.70A 1d1gA-1cz3A:
31.2		 1d1gA-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
GLU A  50
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.36A 1d1gA-1cz3A:
31.2		 1d1gA-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ARG A  32
GLU A  50
ILE A  51
LEU A  55
ILE A 100
 None
 1.15A 1d1gA-1cz3A:
31.2		 1d1gA-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		9 / 12 VAL A   6
ALA A   8
ASP A  27
GLU A  50
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.64A 1d1gB-1cz3A:
31.1		 1d1gB-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		9 / 12 VAL A   6
ALA A   8
ASP A  27
GLU A  50
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.39A 1d1gB-1cz3A:
31.1		 1d1gB-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ARG A  32
GLU A  50
ARG A  53
LEU A  55
ARG A  58
ILE A 100
 None
 1.20A 1d1gB-1cz3A:
31.1		 1d1gB-1cz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ARG A  32
GLU A  50
ILE A  51
LEU A  55
ARG A  58
ILE A 100
 None
 1.02A 1d1gB-1cz3A:
31.1		 1d1gB-1cz3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
THR A  47
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.70A 1ddrA-1cz3A:
19.2		 1ddrA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.72A 1ddrB-1cz3A:
19.8		 1ddrB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.71A 1ddsA-1cz3A:
19.4		 1ddsA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.57A 1ddsA-1cz3A:
19.4		 1ddsA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.73A 1ddsB-1cz3A:
20.0		 1ddsB-1cz3A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LEU A  55
ARG A  58
ILE A 100
 None
 0.47A 1df7A-1cz3A:
17.5		 1df7A-1cz3A:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.71A 1dhfA-1cz3A:
16.3		 1dhfA-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.65A 1dhfB-1cz3A:
16.4		 1dhfB-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.75A 1dhiA-1cz3A:
19.8		 1dhiA-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.74A 1dhiB-1cz3A:
20.1		 1dhiB-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.79A 1dhjA-1cz3A:
19.6		 1dhjA-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
PRO A  56
ARG A  58
ILE A 100
THR A 121
 None
 0.77A 1dhjB-1cz3A:
20.1		 1dhjB-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
 None
 0.73A 1draA-1cz3A:
19.6		 1draA-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.77A 1draB-1cz3A:
20.1		 1draB-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.78A 1drbA-1cz3A:
19.6		 1drbA-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.77A 1drbB-1cz3A:
20.1		 1drbB-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.40A 1drbB-1cz3A:
20.1		 1drbB-1cz3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
 None
 0.65A 1dreA-1cz3A:
19.8		 1dreA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.71A 1dyiA-1cz3A:
19.6		 1dyiA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.42A 1dyiB-1cz3A:
20.2		 1dyiB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A   8
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.55A 1dyrA-1cz3A:
16.8		 1dyrA-1cz3A:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.62A 1j3jA-1cz3A:
17.6		 1j3jA-1cz3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 9 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.52A 1j3jB-1cz3A:
17.7		 1j3jB-1cz3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
THR A 121
 None
 0.53A 1jolA-1cz3A:
19.6		 1jolA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
PRO A  56
THR A 121
 None
 0.42A 1jolB-1cz3A:
20.1		 1jolB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
PRO A  56
THR A 121
 None
 0.86A 1jolB-1cz3A:
20.1		 1jolB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.37A 1jomA-1cz3A:
19.9		 1jomA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.59A 1qzfA-1cz3A:
9.5		 1qzfA-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.59A 1qzfB-1cz3A:
18.7		 1qzfB-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.60A 1qzfC-1cz3A:
10.0		 1qzfC-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.60A 1qzfD-1cz3A:
9.4		 1qzfD-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.61A 1qzfE-1cz3A:
9.4		 1qzfE-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
 0.73A 1ra2A-1cz3A:
20.3		 1ra2A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.74A 1ra3A-1cz3A:
20.1		 1ra3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.74A 1ra8A-1cz3A:
20.3		 1ra8A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
 0.42A 1rb2A-1cz3A:
19.9		 1rb2A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.47A 1rb2B-1cz3A:
20.0		 1rb2B-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
ILE A  51
ARG A  58
ILE A 100
THR A 121
 None
 0.46A 1rb3A-1cz3A:
19.9		 1rb3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.49A 1rb3B-1cz3A:
19.9		 1rb3B-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.37A 1rd7A-1cz3A:
20.0		 1rd7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.69A 1rd7B-1cz3A:
20.2		 1rd7B-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
ILE A 100
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.51A 1re7A-1cz3A:
19.9		 1re7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
PRO A  56
ILE A 100
THR A 121
 None
 0.45A 1re7B-1cz3A:
20.1		 1re7B-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.58A 1rg7A-1cz3A:
19.6		 1rg7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
 None
 0.50A 1rh3A-1cz3A:
19.7		 1rh3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
 0.58A 1rx2A-1cz3A:
20.3		 1rx2A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
 0.54A 1rx3A-1cz3A:
20.3		 1rx3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
 None
 0.45A 1rx3A-1cz3A:
20.3		 1rx3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.39A 1rx7A-1cz3A:
19.8		 1rx7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
ILE A  51
ARG A  53
LEU A  55
PRO A  56
THR A 121
 None
 0.50A 1rx8A-1cz3A:
20.2		 1rx8A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.66A 1tdrA-1cz3A:
19.5		 1tdrA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
THR A  47
ARG A  53
LEU A  55
ARG A  58
 None
SO4  A 200 (-3.7A)
None
None
None
 0.91A 1tdrA-1cz3A:
19.5		 1tdrA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 ALA A   8
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.96A 1tdrB-1cz3A:
20.0		 1tdrB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.55A 1tdrB-1cz3A:
20.0		 1tdrB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.64A 2bl9A-1cz3A:
18.3		 2bl9A-1cz3A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A   8
ASP A  27
PHE A  31
ILE A 100
THR A 121
 None
 0.49A 2blaA-1cz3A:
17.9		 2blaA-1cz3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.71A 2blaA-1cz3A:
17.9		 2blaA-1cz3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
THR A  47
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
SO4  A 200 (-3.7A)
None
None
None
None
 0.46A 2cd2A-1cz3A:
16.9		 2cd2A-1cz3A:
28.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
PRO A  56
ARG A  58
ILE A 100
THR A 121
 None
 0.59A 2d0kA-1cz3A:
19.9		 2d0kA-1cz3A:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.76A 2d0kB-1cz3A:
20.0		 2d0kB-1cz3A:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.54A 2d0kB-1cz3A:
20.0		 2d0kB-1cz3A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
 None
 0.76A 2drcA-1cz3A:
19.7		 2drcA-1cz3A:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.80A 2drcB-1cz3A:
20.3		 2drcB-1cz3A:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.62A 2oipA-1cz3A:
19.3		 2oipA-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LYS A  29
PHE A  31
THR A 121
 None
 1.19A 2oipB-1cz3A:
17.7		 2oipB-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.59A 2oipB-1cz3A:
17.7		 2oipB-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.61A 2oipC-1cz3A:
19.0		 2oipC-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.66A 2oipD-1cz3A:
19.6		 2oipD-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.70A 2oipE-1cz3A:
18.7		 2oipE-1cz3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
ARG A  53
PRO A  56
ARG A  58
 None
 0.85A 2qk8A-1cz3A:
20.2		 2qk8A-1cz3A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
LEU A  55
PRO A  56
ARG A  58
 None
 0.55A 2qk8A-1cz3A:
20.2		 2qk8A-1cz3A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A   8
PHE A  31
THR A  47
ILE A  51
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
 0.71A 2w3aA-1cz3A:
16.4		 2w3aA-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.72A 2w3aB-1cz3A:
16.5		 2w3aB-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.67A 2w3bA-1cz3A:
16.1		 2w3bA-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
THR A 121
 None
 0.63A 2w3bB-1cz3A:
16.1		 2w3bB-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
THR A 121
 None
 0.74A 2w3mA-1cz3A:
16.1		 2w3mA-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
LEU A  55
ARG A  58
THR A 121
 None
 0.54A 2w3mB-1cz3A:
16.1		 2w3mB-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
ILE A 100
THR A 121
 None
 0.63A 2w3vA-1cz3A:
18.9		 2w3vA-1cz3A:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.81A 2zzaA-1cz3A:
20.3		 2zzaA-1cz3A:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.42A 2zzaA-1cz3A:
20.3		 2zzaA-1cz3A:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A   8
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.41A 2zzaB-1cz3A:
19.9		 2zzaB-1cz3A:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
THR A  47
LEU A  55
PRO A  56
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.62A 3cl9A-1cz3A:
18.3		 3cl9A-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 4 VAL A   6
ARG A  32
ILE A  51
THR A 121
 None
 0.77A 3cl9A-1cz3A:
18.3		 3cl9A-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
 0.65A 3clbA-1cz3A:
18.1		 3clbA-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
 None
None
None
SO4  A 200 (-3.7A)
None
 0.69A 3clbB-1cz3A:
17.1		 3clbB-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A 100
 None
None
None
SO4  A 200 (-3.7A)
None
 0.56A 3clbB-1cz3A:
17.1		 3clbB-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.64A 3clbC-1cz3A:
18.1		 3clbC-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
ILE A  51
ILE A 100
THR A 121
 None
 0.63A 3clbD-1cz3A:
18.1		 3clbD-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
 None
 0.49A 3dauA-1cz3A:
20.0		 3dauA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
 0.85A 3dauA-1cz3A:
20.0		 3dauA-1cz3A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.71A 3dfrA-1cz3A:
19.2		 3dfrA-1cz3A:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
 None
 0.75A 3drcA-1cz3A:
19.6		 3drcA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.47A 3drcB-1cz3A:
20.1		 3drcB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.76A 3drcB-1cz3A:
20.1		 3drcB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ILE A 100
 None
 0.67A 3hbbA-1cz3A:
18.1		 3hbbA-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 VAL A   6
ALA A   8
ASP A  27
THR A  47
ILE A 100
 None
None
None
SO4  A 200 (-3.7A)
None
 0.65A 3hbbB-1cz3A:
17.3		 3hbbB-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
 0.62A 3hbbC-1cz3A:
18.2		 3hbbC-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
ILE A  51
ILE A 100
THR A 121
 None
 0.65A 3hbbD-1cz3A:
18.2		 3hbbD-1cz3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.69A 3hj3A-1cz3A:
19.8		 3hj3A-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.63A 3hj3B-1cz3A:
20.0		 3hj3B-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.71A 3hj3C-1cz3A:
18.5		 3hj3C-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.78A 3hj3D-1cz3A:
15.9		 3hj3D-1cz3A:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
 0.94A 3ia4A-1cz3A:
20.2		 3ia4A-1cz3A:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
 0.90A 3ia4B-1cz3A:
20.3		 3ia4B-1cz3A:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
ARG A  58
 None
 0.53A 3ia4C-1cz3A:
20.3		 3ia4C-1cz3A:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
ARG A  58
 None
 0.51A 3ia4D-1cz3A:
20.2		 3ia4D-1cz3A:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ARG A  32
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.88A 3k2hA-1cz3A:
18.1		 3k2hA-1cz3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
 None
 0.60A 3k2hB-1cz3A:
17.4		 3k2hB-1cz3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.75A 3n0hA-1cz3A:
16.7		 3n0hA-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ARG A  32
THR A  47
ILE A  51
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
 0.60A 3nrrA-1cz3A:
17.5		 3nrrA-1cz3A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ARG A  32
THR A  47
ILE A  51
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
 0.59A 3nrrB-1cz3A:
18.3		 3nrrB-1cz3A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 VAL A 163
LEU A 143
PHE A   5
LEU A   7
 None
 1.06A 3qeoB-1cz3A:
2.2		 3qeoB-1cz3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A 100
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
 0.45A 3qfxA-1cz3A:
18.2		 3qfxA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A 100
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
None
 0.46A 3qfxB-1cz3A:
18.2		 3qfxB-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 ALA A   8
ASP A  27
PHE A  31
ILE A  51
THR A 121
 None
 0.59A 3qg2A-1cz3A:
17.5		 3qg2A-1cz3A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 ALA A   8
ASP A  27
PHE A  31
ILE A  51
THR A 121
 None
 0.58A 3qg2B-1cz3A:
17.7		 3qg2B-1cz3A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.63A 3qgtA-1cz3A:
17.6		 3qgtA-1cz3A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.50A 3qgtB-1cz3A:
17.6		 3qgtB-1cz3A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.41A 3ql0A-1cz3A:
19.8		 3ql0A-1cz3A:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
ARG A  58
ILE A 100
THR A 121
 None
 0.59A 3ql3A-1cz3A:
20.3		 3ql3A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.79A 3s3vA-1cz3A:
16.6		 3s3vA-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 9 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ILE A 100
THR A 121
 None
 0.53A 3tq8A-1cz3A:
20.0		 3tq8A-1cz3A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.49A 3tq9A-1cz3A:
20.3		 3tq9A-1cz3A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 11 ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.46A 3tqbA-1cz3A:
20.2		 3tqbA-1cz3A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ASP A  27
PHE A  31
THR A  47
ILE A  51
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.63A 3um5A-1cz3A:
17.6		 3um5A-1cz3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ASP A  27
PHE A  31
THR A  47
ILE A  51
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.62A 3um5B-1cz3A:
17.8		 3um5B-1cz3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.55A 4cd2A-1cz3A:
17.1		 4cd2A-1cz3A:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
THR A  47
ILE A  51
LEU A  55
ARG A  58
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.60A 4dfrA-1cz3A:
19.5		 4dfrA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
THR A  47
ILE A  51
ARG A  53
LEU A  55
ARG A  58
 None
SO4  A 200 (-3.7A)
None
None
None
None
 0.84A 4dfrA-1cz3A:
19.5		 4dfrA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.48A 4dfrB-1cz3A:
20.0		 4dfrB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.89A 4dfrB-1cz3A:
20.0		 4dfrB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
PHE A  31
LEU A  55
ARG A  58
THR A 121
 None
 0.94A 4eckA-1cz3A:
16.8		 4eckA-1cz3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
PHE A  31
LEU A  55
ARG A  58
THR A 121
 None
 0.89A 4eckB-1cz3A:
16.9		 4eckB-1cz3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.51A 4eilA-1cz3A:
17.7		 4eilA-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.55A 4eilB-1cz3A:
18.1		 4eilB-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.49A 4eilC-1cz3A:
17.7		 4eilC-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 VAL A   6
ALA A   8
ASP A  27
ARG A  58
THR A 121
 None
 0.53A 4eilD-1cz3A:
17.2		 4eilD-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.51A 4eilE-1cz3A:
18.2		 4eilE-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.49A 4eilF-1cz3A:
17.2		 4eilF-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.45A 4eilG-1cz3A:
17.7		 4eilG-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 9 VAL A   6
ALA A   8
ASP A  27
LYS A  29
ARG A  58
THR A 121
 None
 1.04A 4eilH-1cz3A:
11.5		 4eilH-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.81A 4ej1A-1cz3A:
20.0		 4ej1A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.51A 4ej1B-1cz3A:
20.0		 4ej1B-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.40A 4fhbA-1cz3A:
20.0		 4fhbA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
 None
 0.47A 4gh8A-1cz3A:
19.1		 4gh8A-1cz3A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.54A 4i13A-1cz3A:
19.9		 4i13A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A  27
ARG A  58
THR A 121
 None
 0.35A 4i13A-1cz3A:
19.9		 4i13A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ARG A  58
THR A 121
 None
 0.40A 4i1nA-1cz3A:
20.0		 4i1nA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.72A 4kebB-1cz3A:
15.9		 4kebB-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
THR A 121
 None
 0.69A 4kfjB-1cz3A:
16.1		 4kfjB-1cz3A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.42A 4kjjA-1cz3A:
19.0		 4kjjA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.44A 4kjkA-1cz3A:
19.9		 4kjkA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
THR A  47
ILE A  51
ARG A  53
ILE A 100
 None
SO4  A 200 (-3.7A)
None
None
None
 0.80A 4kjkA-1cz3A:
19.9		 4kjkA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.46A 4kjlA-1cz3A:
19.8		 4kjlA-1cz3A:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A 100
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
 0.64A 4km0A-1cz3A:
17.7		 4km0A-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A 100
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
 0.61A 4km0B-1cz3A:
17.8		 4km0B-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ILE A 100
THR A 121
 None
 0.65A 4km2A-1cz3A:
17.6		 4km2A-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ASP A  27
PHE A  31
THR A  47
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.61A 4km2A-1cz3A:
17.6		 4km2A-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ILE A 100
THR A 121
 None
 0.65A 4km2B-1cz3A:
17.5		 4km2B-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ASP A  27
PHE A  31
THR A  47
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
 0.42A 4km2B-1cz3A:
17.5		 4km2B-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.52A 4ky8A-1cz3A:
13.2		 4ky8A-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
ALA A   8
ASP A  27
LYS A  29
THR A 121
 None
 1.02A 4ky8A-1cz3A:
13.2		 4ky8A-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.58A 4ky8B-1cz3A:
14.1		 4ky8B-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.62A 4ky8C-1cz3A:
19.8		 4ky8C-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
ALA A   8
ASP A  27
LYS A  29
THR A 121
 None
 1.09A 4ky8C-1cz3A:
19.8		 4ky8C-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.58A 4ky8D-1cz3A:
3.5		 4ky8D-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
ALA A   8
ASP A  27
LYS A  29
THR A 121
 None
 1.07A 4ky8D-1cz3A:
3.5		 4ky8D-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.60A 4ky8E-1cz3A:
19.7		 4ky8E-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
ALA A   8
ASP A  27
LYS A  29
THR A 121
 None
 1.02A 4ky8E-1cz3A:
19.7		 4ky8E-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 VAL A   6
ALA A   8
ASP A  27
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.42A 4kyaA-1cz3A:
17.7		 4kyaA-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.48A 4kyaB-1cz3A:
17.9		 4kyaB-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
TRP A  22
ASP A  27
LEU A  55
ARG A  58
 None
 1.30A 4kyaB-1cz3A:
17.9		 4kyaB-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.42A 4kyaC-1cz3A:
12.8		 4kyaC-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.50A 4kyaD-1cz3A:
11.5		 4kyaD-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
TRP A  22
ASP A  27
LEU A  55
ARG A  58
 None
 1.32A 4kyaD-1cz3A:
11.5		 4kyaD-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 VAL A   6
ALA A   8
ASP A  27
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.41A 4kyaE-1cz3A:
17.7		 4kyaE-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.46A 4kyaF-1cz3A:
11.5		 4kyaF-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
TRP A  22
ASP A  27
LEU A  55
ARG A  58
 None
 1.30A 4kyaF-1cz3A:
11.5		 4kyaF-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 VAL A   6
ALA A   8
ASP A  27
THR A  47
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
 0.41A 4kyaG-1cz3A:
17.7		 4kyaG-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 VAL A   6
ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.51A 4kyaH-1cz3A:
17.2		 4kyaH-1cz3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A   6
TRP A  22
ASP A  27
LEU A  55
ARG A  58
 None
 1.34A 4kyaH-1cz3A:
17.2		 4kyaH-1cz3A:
16.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ILE A 100
 None
 0.47A 4m2xA-1cz3A:
17.4		 4m2xA-1cz3A:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LEU A  55
ILE A 100
THR A 121
 None
 0.52A 4m2xC-1cz3A:
17.6		 4m2xC-1cz3A:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.65A 4m6kA-1cz3A:
16.8		 4m6kA-1cz3A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.53A 4nx6A-1cz3A:
20.3		 4nx6A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.59A 4nx7A-1cz3A:
20.2		 4nx7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 4 ILE A  34
ASP A  27
ARG A  58
THR A 121
 None
 1.49A 4nx7A-1cz3A:
20.2		 4nx7A-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
PRO A  56
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.44A 4p3qA-1cz3A:
20.1		 4p3qA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.42A 4p3rA-1cz3A:
20.1		 4p3rA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A  27
ARG A  58
THR A 121
 None
 0.35A 4p3rA-1cz3A:
20.1		 4p3rA-1cz3A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ASP A  27
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
 0.46A 4p66A-1cz3A:
20.2		 4p66A-1cz3A:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ASP A  27
PHE A  31
ILE A  51
ARG A  58
ILE A 100
THR A 121
 None
 0.48A 4p68A-1cz3A:
19.8		 4p68A-1cz3A:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.44A 4pssA-1cz3A:
undetectable		 4pssA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.48A 4pstA-1cz3A:
undetectable		 4pstA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
PHE A  31
ILE A  51
LEU A  55
THR A 121
 None
 0.45A 4psyA-1cz3A:
20.2		 4psyA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
THR A  47
ILE A  51
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.40A 4pthA-1cz3A:
20.1		 4pthA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  58
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.48A 4ptjA-1cz3A:
20.3		 4ptjA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.57A 4q0dA-1cz3A:
19.7		 4q0dA-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.57A 4q0dB-1cz3A:
19.7		 4q0dB-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.58A 4q0dC-1cz3A:
19.7		 4q0dC-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
ASP A  27
LEU A  55
ARG A  58
THR A 121
 None
 0.58A 4q0dD-1cz3A:
19.7		 4q0dD-1cz3A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 VAL A   6
ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.57A 4q0dE-1cz3A:
19.7		 4q0dE-1cz3A:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.55A 4qi9A-1cz3A:
19.4		 4qi9A-1cz3A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.77A 4qi9A-1cz3A:
19.4		 4qi9A-1cz3A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.77A 4qi9B-1cz3A:
19.6		 4qi9B-1cz3A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.53A 4qi9C-1cz3A:
18.9		 4qi9C-1cz3A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.86A 4qi9C-1cz3A:
18.9		 4qi9C-1cz3A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.74A 4qleA-1cz3A:
20.0		 4qleA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.44A 4qleB-1cz3A:
19.7		 4qleB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 11 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.46A 4qlfA-1cz3A:
18.7		 4qlfA-1cz3A:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.71A 4qlgA-1cz3A:
20.1		 4qlgA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.50A 4qlgB-1cz3A:
19.6		 4qlgB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
ASP A  27
PHE A  31
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.42A 4rgcA-1cz3A:
20.3		 4rgcA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 PHE A 141
LEU A 143
VAL A 115
PHE A 106
 None
 0.93A 4wnvD-1cz3A:
undetectable		 4wnvD-1cz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.72A 4x5fA-1cz3A:
20.2		 4x5fA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.68A 4x5fB-1cz3A:
20.4		 4x5fB-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
ASP A  27
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
THR A 121
 None
None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.73A 4x5gA-1cz3A:
20.2		 4x5gA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
THR A  47
ILE A  51
ARG A  53
LEU A  55
ARG A  58
ILE A 100
THR A 121
 None
SO4  A 200 (-3.7A)
None
None
None
None
None
None
 0.72A 4x5gB-1cz3A:
20.3		 4x5gB-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.47A 4x5hA-1cz3A:
19.7		 4x5hA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.53A 4x5iA-1cz3A:
19.5		 4x5iA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.66A 4x5jA-1cz3A:
19.5		 4x5jA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.48A 4x5jA-1cz3A:
19.5		 4x5jA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ARG A 149
LYS A 160
GLU A 147
 None
 0.82A 5d0yA-1cz3A:
undetectable		 5d0yA-1cz3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.78A 5e8qA-1cz3A:
19.5		 5e8qA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A  27
LEU A  55
ARG A  58
 None
 0.32A 5e8qA-1cz3A:
19.5		 5e8qA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.53A 5e8qB-1cz3A:
20.0		 5e8qB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A   8
THR A  47
ARG A  53
LEU A  55
THR A 121
 None
SO4  A 200 (-3.7A)
None
None
None
 0.82A 5e8qB-1cz3A:
20.0		 5e8qB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.82A 5eajA-1cz3A:
19.5		 5eajA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
PRO A  56
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.50A 5eajB-1cz3A:
20.1		 5eajB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A  27
ARG A  53
ARG A  58
 None
 0.85A 5eajB-1cz3A:
20.1		 5eajB-1cz3A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.56A 5hi6A-1cz3A:
20.1		 5hi6A-1cz3A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.90A 5hi6A-1cz3A:
20.1		 5hi6A-1cz3A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ASP A  27
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
 0.56A 5hi6B-1cz3A:
19.5		 5hi6B-1cz3A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
ILE A  51
ARG A  53
LEU A  55
ARG A  58
THR A 121
 None
 0.88A 5hi6B-1cz3A:
19.5		 5hi6B-1cz3A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 ALA A   8
ASP A  27
ILE A 100
THR A 121
 None
 0.46A 5uihA-1cz3A:
20.0		 5uihA-1cz3A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		8 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  53
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
None
 0.80A 5ujxA-1cz3A:
19.5		 5ujxA-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.48A 5ujxB-1cz3A:
20.0		 5ujxB-1cz3A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
ARG A  58
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
 0.42A 5z6fA-1cz3A:
20.5		 5z6fA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 ALA A   8
THR A  47
ILE A  51
ARG A  53
ARG A  58
THR A 121
 None
SO4  A 200 (-3.7A)
None
None
None
None
 0.68A 5z6fA-1cz3A:
20.5		 5z6fA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.49A 5z6jA-1cz3A:
20.2		 5z6jA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.50A 5z6kA-1cz3A:
20.1		 5z6kA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 ALA A   8
ASP A  27
ILE A  51
PRO A  56
ARG A  58
 None
 0.53A 5z6lA-1cz3A:
19.9		 5z6lA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 11 ALA A   8
ASP A  27
PHE A  31
LEU A  55
ILE A 100
THR A 121
 None
 0.78A 5z6mA-1cz3A:
19.8		 5z6mA-1cz3A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
 0.51A 6aogA-1cz3A:
17.8		 6aogA-1cz3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		6 / 10 VAL A   6
ALA A   8
ASP A  27
PHE A  31
THR A  47
THR A 121
 None
None
None
None
SO4  A 200 (-3.7A)
None
 0.53A 6aogB-1cz3A:
17.6		 6aogB-1cz3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 PHE A 106
THR A 104
GLY A  44
ILE A  15
ILE A 131
 None
SO4  A 200 (-4.0A)
SO4  A 200 (-3.3A)
None
None
 1.01A 6ebzA-1cz3A:
undetectable		 6ebzA-1cz3A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 ASN A  40
TYR A  94
VAL A  42
VAL A  86
 None
 1.46A 6f32B-1cz3A:
undetectable		 6f32B-1cz3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cz3 DIHYDROFOLATE
REDUCTASE
(Thermotoga
maritima) 		7 / 12 ALA A   8
PHE A  31
THR A  47
ILE A  51
LEU A  55
ILE A 100
THR A 121
 None
None
SO4  A 200 (-3.7A)
None
None
None
None
 0.61A 7dfrA-1cz3A:
19.7		 7dfrA-1cz3A:
29.05