SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 10 GLU A  43
ARG A  88
LEU A 130
GLU A 131
GLY A  78
 None
 1.21A 1cmcA-1cz4A:
undetectable
1cmcB-1cz4A:
undetectable		 1cmcA-1cz4A:
18.48
1cmcB-1cz4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 8 VAL A  24
LEU A  26
ILE A  44
VAL A  87
LEU A   9
 None
 1.37A 3kp6A-1cz4A:
undetectable
3kp6B-1cz4A:
undetectable		 3kp6A-1cz4A:
21.58
3kp6B-1cz4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 8 VAL A  87
VAL A  85
MET A  73
ILE A  69
 None
 0.75A 3warA-1cz4A:
undetectable		 3warA-1cz4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 5 ASP A 133
THR A  50
LEU A 130
GLU A 131
 None
 1.46A 4a3pA-1cz4A:
undetectable		 4a3pA-1cz4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		3 / 3 VAL A 120
ARG A 105
PRO A 176
 None
 0.73A 5koxA-1cz4A:
undetectable		 5koxA-1cz4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1cz4 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A  78
MET A  21
VAL A  85
ASN A 134
LEU A 149
 None
 1.34A 5nz0A-1cz4A:
undetectable		 5nz0A-1cz4A:
21.98