SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1czf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 7 PHE A 152
PHE A 128
PHE A  80
HIS A 105
 None
 0.90A 1lh6A-1czfA:
undetectable		 1lh6A-1czfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 ILE A 275
VAL A 344
GLY A 284
LEU A 225
TYR A 272
 None
 1.27A 1s1uA-1czfA:
0.0		 1s1uA-1czfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 TRP A 115
GLY A 176
GLY A 175
ASN A 168
ASP A 202
 None
 1.02A 2dpmA-1czfA:
undetectable		 2dpmA-1czfA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 5 VAL A 190
SER A 208
VAL A 238
SER A 187
 None
 1.40A 2j9cA-1czfA:
undetectable
2j9cB-1czfA:
undetectable
2j9cC-1czfA:
0.0		 2j9cA-1czfA:
13.64
2j9cB-1czfA:
13.64
2j9cC-1czfA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 7 GLY A 171
ASP A 110
TRP A 114
ARG A 113
 None
ZN  A 501 (-2.0A)
None
None
 1.27A 3arrA-1czfA:
undetectable		 3arrA-1czfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 GLY A 228
VAL A 230
ILE A 257
ALA A 205
VAL A 241
 None
 1.01A 3fpjA-1czfA:
undetectable		 3fpjA-1czfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 9 ALA A  38
LEU A  61
VAL A  72
ILE A 107
LEU A 142
 None
 1.19A 3jw3B-1czfA:
undetectable		 3jw3B-1czfA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 ASN A 253
VAL A 309
ILE A 270
ILE A 227
SER A 226
 None
 1.20A 3kpbA-1czfA:
undetectable		 3kpbA-1czfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 ILE A 107
GLY A 101
ILE A  73
THR A  78
ILE A  53
 None
 1.14A 3s56A-1czfA:
undetectable		 3s56A-1czfA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 9 PHE A 128
ASN A 143
ILE A 107
THR A 147
PHE A 152
 None
 1.27A 3t3rC-1czfA:
0.0		 3t3rC-1czfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 11 THR A  78
LEU A 142
VAL A  99
LEU A  61
PHE A  80
 None
 1.23A 3tbgA-1czfA:
0.0		 3tbgA-1czfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 THR A  78
LEU A 142
VAL A  99
LEU A  61
PHE A  80
 None
 1.23A 3tbgC-1czfA:
0.0		 3tbgC-1czfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 ASN A 191
ILE A 270
GLY A 209
SER A 187
ILE A 212
 None
 1.23A 4djfA-1czfA:
undetectable		 4djfA-1czfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 11 PHE A 129
LEU A  50
ILE A  48
SER A 138
ILE A 107
 None
 1.16A 4dm8A-1czfA:
undetectable		 4dm8A-1czfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 5 GLY A 101
ALA A 102
PHE A  74
GLU A  75
 None
 0.77A 4m93B-1czfA:
undetectable
4m93C-1czfA:
undetectable		 4m93B-1czfA:
22.07
4m93C-1czfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 8 PRO A 357
SER A 358
VAL A 359
GLY A 332
 None
 0.89A 4mk4A-1czfA:
undetectable		 4mk4A-1czfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 VAL A 190
ILE A 192
PHE A 182
VAL A 184
GLY A 185
 None
 0.77A 5j2tC-1czfA:
undetectable		 5j2tC-1czfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 12 ILE A 260
LEU A 204
VAL A 241
VAL A 309
ILE A 306
 None
 1.05A 5mugA-1czfA:
undetectable		 5mugA-1czfA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		4 / 7 ILE A  97
LEU A  50
PHE A  32
THR A  60
 None
 1.03A 5vc0A-1czfA:
0.0		 5vc0A-1czfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 SER A 153
SER A  93
LEU A 134
ASP A 135
PRO A  88
 None
 1.09A 6dlzB-1czfA:
undetectable
6dlzC-1czfA:
undetectable		 6dlzB-1czfA:
11.60
6dlzC-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 11 PRO A  88
SER A 153
SER A  93
LEU A 134
ASP A 135
 None
 1.09A 6dlzA-1czfA:
undetectable
6dlzD-1czfA:
undetectable		 6dlzA-1czfA:
11.60
6dlzD-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 SER A 153
SER A  93
LEU A 134
ASP A 135
PRO A  88
 None
 1.09A 6dm1B-1czfA:
undetectable
6dm1C-1czfA:
undetectable		 6dm1B-1czfA:
11.60
6dm1C-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 11 PRO A  88
SER A 153
SER A  93
LEU A 134
ASP A 135
 None
 1.08A 6dm1A-1czfA:
undetectable
6dm1D-1czfA:
undetectable		 6dm1A-1czfA:
11.60
6dm1D-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 SER A 153
SER A  93
LEU A 134
ASP A 135
PRO A  88
 None
 1.09A 6dm2B-1czfA:
undetectable
6dm2C-1czfA:
undetectable		 6dm2B-1czfA:
11.60
6dm2C-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1czf POLYGALACTURONASE II
(Aspergillus
niger) 		5 / 10 PRO A  88
SER A 153
SER A  93
LEU A 134
ASP A 135
 None
 1.09A 6dm2A-1czfA:
undetectable
6dm2D-1czfA:
undetectable		 6dm2A-1czfA:
11.60
6dm2D-1czfA:
11.60