SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1czv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens) 		5 / 10 GLY A  75
LEU A 153
GLU A 152
HIS A 122
LEU A  38
 None
 1.37A 1cmcA-1czvA:
undetectable
1cmcB-1czvA:
undetectable		 1cmcA-1czvA:
22.84
1cmcB-1czvA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens) 		5 / 12 GLY A   6
ILE A 136
ILE A  68
ILE A  72
ILE A  60
 None
 0.82A 2hs1A-1czvA:
undetectable		 2hs1A-1czvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens) 		5 / 12 GLY A   6
ILE A 136
ILE A  68
ILE A  72
ILE A  60
 None
 0.77A 2hs1B-1czvA:
undetectable		 2hs1B-1czvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens) 		4 / 6 GLY A 115
PRO A 140
LYS A 141
THR A 142
 None
 0.96A 2m2oB-1czvA:
undetectable		 2m2oB-1czvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens) 		5 / 8 ILE A  71
ILE A 131
PHE A 127
GLU A  59
LEU A  62
 None
 1.36A 3ua5A-1czvA:
0.0		 3ua5A-1czvA:
16.41