SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 1d1j PROFILIN II
(Homo
sapiens) 		5 / 12 ASN A  99
GLY A 114
GLN A  17
ILE A  73
LEU A 123
 SO4  A 800 (-3.1A)
None
None
None
None
 1.43A 1m2zD-1d1jA:
undetectable		 1m2zD-1d1jA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.90A 1v55N-1d1jA:
undetectable
1v55W-1d1jA:
undetectable		 1v55N-1d1jA:
15.87
1v55W-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1d1j PROFILIN II
(Homo
sapiens) 		5 / 12 ALA A 108
GLY A 103
VAL A 102
VAL A   7
ILE A  21
 None
 1.06A 2o4lA-1d1jA:
undetectable		 2o4lA-1d1jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.84A 3abkA-1d1jA:
undetectable
3abkJ-1d1jA:
undetectable		 3abkA-1d1jA:
15.87
3abkJ-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.91A 3abmN-1d1jA:
undetectable
3abmW-1d1jA:
undetectable		 3abmN-1d1jA:
15.87
3abmW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 7 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.87A 3ag2N-1d1jA:
undetectable
3ag2W-1d1jA:
undetectable		 3ag2N-1d1jA:
15.87
3ag2W-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 7 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.88A 3ag4N-1d1jA:
undetectable
3ag4W-1d1jA:
undetectable		 3ag4N-1d1jA:
15.87
3ag4W-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.89A 3asoN-1d1jA:
undetectable
3asoW-1d1jA:
undetectable		 3asoN-1d1jA:
15.87
3asoW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 4 PRO A  96
THR A  97
GLY A 120
THR A 122
 None
None
SO4  A 800 (-3.6A)
None
 1.15A 3ib1A-1d1jA:
undetectable		 3ib1A-1d1jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1d1j PROFILIN II
(Homo
sapiens) 		6 / 9 GLY A  23
ALA A 108
GLY A 103
VAL A 102
VAL A   7
ILE A  21
 None
 1.25A 3oxvA-1d1jA:
undetectable		 3oxvA-1d1jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 GLU A  18
ALA A  19
ALA A  20
MET A  11
 None
 0.76A 3r9tA-1d1jA:
undetectable		 3r9tA-1d1jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 7 GLU A  18
ALA A  19
ALA A  20
MET A  11
 None
 0.78A 3r9tB-1d1jA:
undetectable		 3r9tB-1d1jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1d1j PROFILIN II
(Homo
sapiens) 		5 / 12 TYR A 128
GLY A 103
MET A  85
ILE A 111
LEU A  10
 None
 1.22A 4kovA-1d1jA:
0.0		 4kovA-1d1jA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 7 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.92A 5b1bN-1d1jA:
undetectable
5b1bW-1d1jA:
undetectable		 5b1bN-1d1jA:
15.87
5b1bW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 7 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.84A 5b3sN-1d1jA:
undetectable
5b3sW-1d1jA:
undetectable		 5b3sN-1d1jA:
15.87
5b3sW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1d1j PROFILIN II
(Homo
sapiens) 		4 / 8 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.88A 5zcpN-1d1jA:
undetectable
5zcpW-1d1jA:
undetectable		 5zcpN-1d1jA:
15.87
5zcpW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1d1j PROFILIN II
(Homo
sapiens) 		5 / 12 GLY A  23
GLY A 103
VAL A 102
VAL A   7
ILE A  21
 None
 0.99A 6dh6A-1d1jA:
undetectable		 6dh6A-1d1jA:
16.80