SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.14A 1tw4A-1d1pA:
undetectable		 1tw4A-1d1pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.18A 2jn3A-1d1pA:
undetectable		 2jn3A-1d1pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.16A 2qo5A-1d1pA:
undetectable		 2qo5A-1d1pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 130
ILE A  26
LYS A  28
CYH A  65
THR A  61
 None
 1.12A 2qo5A-1d1pA:
undetectable		 2qo5A-1d1pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 130
PHE A 116
ILE A 148
THR A 128
 None
 1.07A 3ia4A-1d1pA:
undetectable		 3ia4A-1d1pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 136
CYH A  13
MET A  93
PHE A 151
 None
EPE  A 201 (-3.3A)
None
None
 0.92A 3ko0D-1d1pA:
undetectable
3ko0E-1d1pA:
undetectable		 3ko0D-1d1pA:
23.36
3ko0E-1d1pA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 136
CYH A  13
MET A  93
PHE A 151
 None
EPE  A 201 (-3.3A)
None
None
 0.84A 3ko0B-1d1pA:
undetectable
3ko0J-1d1pA:
undetectable		 3ko0B-1d1pA:
23.36
3ko0J-1d1pA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1d1p TYROSINE PHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 122
ASP A 118
GLY A 117
 None
 0.51A 5fctB-1d1pA:
0.0		 5fctB-1d1pA:
17.95