SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		6 / 11 CYH A  46
HIS A  67
LEU A 110
LEU A 141
CYH A 174
VAL A 294
 ZN  A 376 ( 2.3A)
ZN  A 376 ( 3.3A)
None
ACT  A 501 (-4.8A)
ZN  A 376 (-2.0A)
NAD  A1377 ( 4.1A)
 0.54A 1ee2A-1d1tA:
63.3		 1ee2A-1d1tA:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		6 / 11 CYH A  46
HIS A  67
LEU A 110
LEU A 141
CYH A 174
VAL A 294
 ZN  A 376 ( 2.3A)
ZN  A 376 ( 3.3A)
None
ACT  A 501 (-4.8A)
ZN  A 376 (-2.0A)
NAD  A1377 ( 4.1A)
 0.53A 1ee2B-1d1tA:
63.4		 1ee2B-1d1tA:
70.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		3 / 3 ARG A 120
THR A 128
VAL A 122
 None
ACT  A 502 ( 4.3A)
None
 0.96A 1hxbA-1d1tA:
0.0		 1hxbA-1d1tA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 8 ILE A 368
GLY A 199
ILE A 269
LEU A 362
 None
NAD  A1377 ( 3.7A)
NAD  A1377 (-4.0A)
None
 0.73A 2o4nB-1d1tA:
undetectable		 2o4nB-1d1tA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 5 LEU A 345
ILE A 172
SER A 177
GLY A 179
 None
 0.96A 2otfA-1d1tA:
undetectable		 2otfA-1d1tA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 12 GLY A 175
GLY A 199
GLY A 201
SER A 206
ILE A 269
 NAD  A1377 ( 4.8A)
NAD  A1377 ( 3.7A)
NAD  A1377 (-3.2A)
None
NAD  A1377 (-4.0A)
 1.14A 2wa2A-1d1tA:
5.0		 2wa2A-1d1tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 12 GLY A 179
GLY A 199
GLY A 201
SER A 206
ILE A 269
 None
NAD  A1377 ( 3.7A)
NAD  A1377 (-3.2A)
None
NAD  A1377 (-4.0A)
 0.77A 2wa2A-1d1tA:
5.0		 2wa2A-1d1tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 9 VAL A 290
VAL A 291
GLY A 316
THR A 178
GLY A 181
 None
None
None
NAD  A1377 (-2.8A)
None
 1.40A 3bjwG-1d1tA:
0.0		 3bjwG-1d1tA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 8 GLY A 119
CYH A  46
PHE A 359
PHE A 140
 None
ZN  A 376 ( 2.3A)
None
None
 0.95A 3ko0D-1d1tA:
undetectable
3ko0E-1d1tA:
undetectable		 3ko0D-1d1tA:
15.01
3ko0E-1d1tA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 7 GLY A 119
CYH A  46
PHE A 359
PHE A 140
 None
ZN  A 376 ( 2.3A)
None
None
 1.00A 3ko0L-1d1tA:
undetectable
3ko0N-1d1tA:
undetectable		 3ko0L-1d1tA:
15.01
3ko0N-1d1tA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 7 PHE A 140
GLY A 119
CYH A  46
PHE A 359
 None
None
ZN  A 376 ( 2.3A)
None
 0.93A 3ko0K-1d1tA:
undetectable
3ko0S-1d1tA:
undetectable		 3ko0K-1d1tA:
15.01
3ko0S-1d1tA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 12 GLY A  66
VAL A 371
LEU A 171
CYH A 174
PHE A  93
 None
None
None
ZN  A 376 (-2.0A)
ACT  A 501 (-3.6A)
 1.42A 3mnoA-1d1tA:
undetectable		 3mnoA-1d1tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 5 THR A 147
THR A 145
SER A 144
PHE A 130
 None
 1.20A 3snfA-1d1tA:
0.0		 3snfA-1d1tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 11 GLY A 204
ALA A 182
GLY A 179
VAL A 197
CYH A 211
 None
 1.19A 4c5lA-1d1tA:
4.8		 4c5lA-1d1tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 10 GLY A 204
ALA A 182
GLY A 179
VAL A 197
CYH A 211
 None
 1.21A 4c5lC-1d1tA:
4.8		 4c5lC-1d1tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 10 GLY A 204
ALA A 182
GLY A 179
VAL A 197
CYH A 211
 None
 1.17A 4c5lD-1d1tA:
undetectable		 4c5lD-1d1tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 10 GLY A 204
ALA A 182
GLY A 179
VAL A 197
CYH A 211
 None
 1.16A 4c5nD-1d1tA:
3.8		 4c5nD-1d1tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 8 GLU A 360
GLN A 366
GLY A 365
SER A 364
 ZN  A 408 (-2.8A)
None
None
None
 0.89A 4f93B-1d1tA:
2.0		 4f93B-1d1tA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 8 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.89A 4jq1B-1d1tA:
undetectable		 4jq1B-1d1tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 6 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.81A 4l1wB-1d1tA:
undetectable		 4l1wB-1d1tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 9 PRO A 243
LEU A 200
GLY A 199
ILE A 241
VAL A 197
 None
None
NAD  A1377 ( 3.7A)
None
None
 1.10A 4x3mA-1d1tA:
2.8		 4x3mA-1d1tA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 9 PRO A 243
LEU A 200
GLY A 199
ILE A 241
VAL A 197
 None
None
NAD  A1377 ( 3.7A)
None
None
 1.17A 4x3mB-1d1tA:
2.6		 4x3mB-1d1tA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 11 PHE A 176
ALA A 183
VAL A 184
SER A 177
GLY A 179
 None
 1.20A 4xnxA-1d1tA:
0.0		 4xnxA-1d1tA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 10 PHE A 176
ALA A 183
VAL A 184
SER A 177
GLY A 179
 None
 1.35A 4xp1A-1d1tA:
0.0		 4xp1A-1d1tA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 7 PHE A  21
ILE A  53
PHE A 146
THR A 370
 None
 0.95A 4zdzA-1d1tA:
0.0		 4zdzA-1d1tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 8 SER A 213
GLY A 210
ILE A 172
GLY A 181
 None
 0.76A 5alcL-1d1tA:
undetectable		 5alcL-1d1tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		6 / 12 ALA A 158
PHE A  21
ILE A  53
PHE A 146
THR A 370
THR A  70
 None
 1.38A 5jlcA-1d1tA:
undetectable		 5jlcA-1d1tA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 6 GLY A 320
THR A 178
SER A 177
GLY A 175
 None
NAD  A1377 (-2.8A)
None
NAD  A1377 ( 4.8A)
 0.82A 5k4pA-1d1tA:
undetectable		 5k4pA-1d1tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		3 / 3 VAL A  58
LYS A 299
MET A 300
 None
 0.97A 5nknA-1d1tA:
0.0		 5nknA-1d1tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		5 / 10 VAL A  65
PHE A  21
LEU A 372
ILE A  45
THR A  43
 None
 1.22A 6d9hR-1d1tA:
undetectable		 6d9hR-1d1tA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens) 		4 / 5 PHE A 140
VAL A 203
MET A  57
VAL A  65
 None
NAD  A1377 (-3.7A)
None
None
 1.27A 6ekzA-1d1tA:
undetectable		 6ekzA-1d1tA:
11.76