SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1d1z SAP SH2 DOMAIN
(Homo
sapiens) 		5 / 11 LEU A1020
LEU A1021
ALA A1022
ILE A1011
HIS A1008
 None
 1.18A 1g50A-1d1zA:
undetectable		 1g50A-1d1zA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1d1z SAP SH2 DOMAIN
(Homo
sapiens) 		3 / 3 LYS A1089
ILE A1096
THR A1068
 None
 0.79A 1rx3A-1d1zA:
undetectable		 1rx3A-1d1zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1d1z SAP SH2 DOMAIN
(Homo
sapiens) 		4 / 7 ASP A1033
VAL A1004
ILE A1084
TYR A1007
 None
 0.99A 3pglA-1d1zA:
undetectable		 3pglA-1d1zA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1d1z SAP SH2 DOMAIN
(Homo
sapiens) 		3 / 3 LYS A1089
ILE A1096
THR A1068
 None
 0.81A 4gh8A-1d1zA:
undetectable		 4gh8A-1d1zA:
18.52