SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 9 THR A 117
VAL A 236
ILE A 216
VAL A 177
ILE A 148
 None
 1.08A 1gebA-1d2eA:
0.0		 1gebA-1d2eA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 9 TYR A 115
VAL A 236
ILE A 216
VAL A 177
ILE A 148
 None
 1.17A 1gebA-1d2eA:
0.0		 1gebA-1d2eA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 5 ILE A 415
ARG A 281
LEU A 381
PRO A 261
 None
 1.50A 1s8fA-1d2eA:
15.7
1s8fB-1d2eA:
15.2		 1s8fA-1d2eA:
17.05
1s8fB-1d2eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 ASP A 132
GLY A  61
ILE A 148
THR A 161
 None
 0.69A 1t7iB-1d2eA:
undetectable		 1t7iB-1d2eA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 ASP A 132
GLY A  61
ILE A 148
THR A 161
 None
 0.68A 1t7jB-1d2eA:
undetectable		 1t7jB-1d2eA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLU A 353
ALA A 354
ILE A 138
ASP A 403
PHE A 422
 None
 1.27A 2admA-1d2eA:
undetectable		 2admA-1d2eA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 6 ARG A 411
SER A 296
GLY A 294
ARG A 335
 None
 1.25A 2f7fA-1d2eA:
2.4		 2f7fA-1d2eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 12 GLY A 105
GLY A 434
GLY A 432
THR A 437
ILE A 138
 None
 0.95A 2wa2B-1d2eA:
undetectable		 2wa2B-1d2eA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 6 VAL A 150
ASP A 126
HIS A 124
ASN A 181
 None
MG  A 501 ( 3.9A)
None
GDP  A1301 (-3.1A)
 1.21A 2zs9A-1d2eA:
0.6		 2zs9A-1d2eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.36A 3abkA-1d2eA:
0.0
3abkB-1d2eA:
0.0
3abkT-1d2eA:
0.0		 3abkA-1d2eA:
21.96
3abkB-1d2eA:
19.61
3abkT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.42A 3ablA-1d2eA:
0.0
3ablB-1d2eA:
0.0
3ablT-1d2eA:
0.0		 3ablA-1d2eA:
21.96
3ablB-1d2eA:
19.61
3ablT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 9 PRO A 369
GLY A 365
ILE A 106
TYR A 357
GLY A 401
 None
 1.26A 3csjB-1d2eA:
undetectable		 3csjB-1d2eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 12 ILE A  95
ALA A  98
GLU A 114
PRO A 143
ASN A  59
 None
 1.23A 3eigA-1d2eA:
undetectable		 3eigA-1d2eA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 12 ILE A 247
ASP A 244
LEU A 240
ILE A 148
LEU A  73
 None
 1.19A 3k2hB-1d2eA:
undetectable		 3k2hB-1d2eA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.40A 3wg7A-1d2eA:
0.0
3wg7B-1d2eA:
0.0
3wg7T-1d2eA:
0.0		 3wg7A-1d2eA:
21.96
3wg7B-1d2eA:
19.61
3wg7T-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 3x2qA-1d2eA:
0.0
3x2qB-1d2eA:
0.0
3x2qT-1d2eA:
0.0		 3x2qA-1d2eA:
21.96
3x2qB-1d2eA:
19.61
3x2qT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 6 PHE A 370
ALA A 398
GLY A 432
LEU A 406
VAL A 356
 None
 1.39A 4dubB-1d2eA:
0.0		 4dubB-1d2eA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.92A 4eq4A-1d2eA:
undetectable		 4eq4A-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 8 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.87A 4eq4B-1d2eA:
undetectable		 4eq4B-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 LEU A 359
THR A 430
THR A 139
GLY A 434
 None
 0.95A 4eqlA-1d2eA:
1.4		 4eqlA-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.92A 4eqlA-1d2eA:
1.4		 4eqlA-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.93A 4eqlB-1d2eA:
1.4		 4eqlB-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 7 THR A 139
ILE A 106
THR A 430
GLY A 432
 None
 0.89A 4l39B-1d2eA:
undetectable		 4l39B-1d2eA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		3 / 3 LEU A 406
MET A 378
TYR A 357
 None
 0.78A 4p6xG-1d2eA:
undetectable		 4p6xG-1d2eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5b1aA-1d2eA:
0.0
5b1aB-1d2eA:
0.0
5b1aT-1d2eA:
0.0		 5b1aA-1d2eA:
21.96
5b1aB-1d2eA:
19.61
5b1aT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.44A 5b1bA-1d2eA:
0.0
5b1bB-1d2eA:
0.0
5b1bT-1d2eA:
0.0		 5b1bA-1d2eA:
21.96
5b1bB-1d2eA:
19.61
5b1bT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.42A 5xdqA-1d2eA:
0.0
5xdqB-1d2eA:
0.0
5xdqT-1d2eA:
0.0		 5xdqA-1d2eA:
21.96
5xdqB-1d2eA:
19.61
5xdqT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5z84A-1d2eA:
0.0
5z84B-1d2eA:
0.0
5z84T-1d2eA:
0.0		 5z84A-1d2eA:
21.96
5z84B-1d2eA:
19.61
5z84T-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5z86A-1d2eA:
0.0
5z86B-1d2eA:
0.0
5z86T-1d2eA:
0.0		 5z86A-1d2eA:
21.96
5z86B-1d2eA:
19.61
5z86T-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5zcoA-1d2eA:
0.0
5zcoB-1d2eA:
0.0
5zcoT-1d2eA:
0.0		 5zcoA-1d2eA:
21.96
5zcoB-1d2eA:
19.61
5zcoT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5zcpA-1d2eA:
0.0
5zcpB-1d2eA:
0.0
5zcpT-1d2eA:
0.0		 5zcpA-1d2eA:
21.96
5zcpB-1d2eA:
19.61
5zcpT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.43A 5zcqA-1d2eA:
0.0
5zcqB-1d2eA:
0.0
5zcqT-1d2eA:
0.0		 5zcqA-1d2eA:
21.96
5zcqB-1d2eA:
19.61
5zcqT-1d2eA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		4 / 8 VAL A 192
HIS A  68
ASN A 181
TYR A 179
 None
None
GDP  A1301 (-3.1A)
None
 1.22A 6gneB-1d2eA:
2.5		 6gneB-1d2eA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d2e ELONGATION FACTOR TU
(EF-TU)
(Bos
taurus) 		5 / 11 GLY A 172
GLN A 170
THR A 437
PHE A 206
GLY A 207
 None
 1.33A 6nknA-1d2eA:
0.0
6nknB-1d2eA:
0.0
6nknT-1d2eA:
0.0		 6nknA-1d2eA:
21.96
6nknB-1d2eA:
19.61
6nknT-1d2eA:
12.20