SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 167
ALA A 120
VAL A 114
ILE A 116
 None
 0.63A 1d4yB-1d2fA:
undetectable		 1d4yB-1d2fA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 5 MET A 306
ALA A 303
TYR A 301
ILE A 302
 None
 1.15A 1upfC-1d2fA:
4.1		 1upfC-1d2fA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 4 MET A 306
ALA A 303
TYR A 301
ILE A 302
 None
 1.26A 1upfD-1d2fA:
2.4		 1upfD-1d2fA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 328
PRO A 330
LEU A 331
ARG A 387
 None
 1.32A 2hrcB-1d2fA:
3.4		 2hrcB-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 295
MET A 207
LEU A 288
MET A  38
 None
 0.96A 2kuhA-1d2fA:
0.6		 2kuhA-1d2fA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		5 / 5 LEU A 328
PRO A 330
LEU A 331
ILE A 386
ARG A 387
 None
 1.21A 2qd4A-1d2fA:
3.2		 2qd4A-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d2f MALY PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 328
LEU A 331
ARG A 387
 None
 0.54A 3hcnB-1d2fA:
3.4		 3hcnB-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 328
PRO A 330
LEU A 331
ARG A 387
 None
 1.30A 3hcoA-1d2fA:
2.0		 3hcoA-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 341
ILE A 343
GLY A 381
ILE A 383
LEU A 338
 None
 1.06A 3ogpA-1d2fA:
0.0		 3ogpA-1d2fA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 176
ASN A 173
LEU A 323
THR A 300
LEU A 299
 None
PLP  A 400 (-4.0A)
None
None
None
 1.08A 3p2kB-1d2fA:
2.2		 3p2kB-1d2fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		3 / 3 THR A 275
VAL A 271
GLU A  68
 None
 0.67A 3v4tA-1d2fA:
0.0
3v4tD-1d2fA:
0.3		 3v4tA-1d2fA:
22.86
3v4tD-1d2fA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 168
LEU A 167
LEU A 228
MET A 205
 None
 0.78A 3vhuA-1d2fA:
0.1		 3vhuA-1d2fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 288
SER A 234
TYR A 281
HIS A  81
 None
 1.37A 4arcA-1d2fA:
0.3		 4arcA-1d2fA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 6 PRO A 137
GLY A 357
ALA A 139
GLU A 359
 None
 1.10A 4g0uA-1d2fA:
2.1		 4g0uA-1d2fA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 8 ARG A 253
PRO A 216
PHE A  77
ILE A  85
 None
 1.01A 4j4vC-1d2fA:
0.1		 4j4vC-1d2fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 328
LEU A 331
ILE A 386
ARG A 387
 None
 0.93A 4klrA-1d2fA:
2.2		 4klrA-1d2fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 5 PRO A 330
LEU A 331
ILE A 386
ARG A 387
 None
 0.95A 4klrA-1d2fA:
2.2		 4klrA-1d2fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 103
ASP A 201
ALA A 226
VAL A 198
ILE A 116
 None
PLP  A 400 (-2.9A)
None
None
None
 1.30A 4uuuA-1d2fA:
0.0
4uuuB-1d2fA:
0.0		 4uuuA-1d2fA:
17.30
4uuuB-1d2fA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 4 PHE A 235
ASP A 206
GLY A 284
SER A 234
 None
 1.18A 4xp9C-1d2fA:
0.0		 4xp9C-1d2fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		3 / 3 ALA A 123
TYR A 125
PRO A 174
 None
 0.69A 4zdyA-1d2fA:
undetectable		 4zdyA-1d2fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1d2f MALY PROTEIN
(Escherichia
coli) 		4 / 4 VAL A 389
ALA A 388
ASN A 384
GLN A 345
 None
 1.21A 4zgfA-1d2fA:
undetectable		 4zgfA-1d2fA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1d2f MALY PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 375
VAL A 364
VAL A 379
ALA A 380
LEU A 382
ALA A 385
 None
 1.24A 5kpcA-1d2fA:
3.4		 5kpcA-1d2fA:
20.45