SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)
1d2k CHITINASE 1
(Coccidioides
immitis)
6 / 9 TYR A  43
PHE A  71
GLY A 130
ASP A 169
ASP A 240
TRP A 378
None
0.92A 1e9lA-1d2kA:
43.7
1e9lA-1d2kA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 9 TYR A  43
PHE A  71
GLY A 130
ASP A 169
MET A 237
TYR A 239
ASP A 240
None
0.75A 1e9lA-1d2kA:
43.7
1e9lA-1d2kA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 8 GLY A 130
GLY A 129
ILE A 128
PRO A 140
ALA A 141
None
1.08A 1sguA-1d2kA:
undetectable
1sguA-1d2kA:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
10 / 11 TYR A  43
PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.34A 2a3aA-1d2kA:
64.9
2a3aA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1434_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
3 / 3 TRP A  47
THR A 132
TYR A 133
None
0.28A 2a3aA-1d2kA:
64.9
2a3aA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2433_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
8 / 9 PHE A  71
GLY A 130
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.30A 2a3aB-1d2kA:
65.4
2a3aB-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2434_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
3 / 3 TRP A  47
THR A 132
TYR A 133
None
0.33A 2a3aB-1d2kA:
65.4
2a3aB-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1433_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 5 TRP A 131
TYR A 172
MET A 237
ASP A 240
None
0.49A 2a3bA-1d2kA:
65.0
2a3bA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1434_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
3 / 3 TRP A  47
THR A 132
TYR A 133
None
0.27A 2a3bA-1d2kA:
65.0
2a3bA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
11 / 11 TYR A  43
PHE A  71
GLY A 130
TRP A 131
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.47A 2a3bA-1d2kA:
65.0
2a3bA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2434_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 6 GLU A 171
TYR A 172
ASP A 240
ARG A 295
None
0.49A 2a3bB-1d2kA:
65.4
2a3bB-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
9 / 10 PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.43A 2a3bB-1d2kA:
65.4
2a3bB-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
11 / 12 TYR A  43
TRP A  47
PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.45A 2a3cA-1d2kA:
65.1
2a3cA-1d2kA:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
11 / 12 TRP A  47
PHE A  71
GLY A 130
THR A 132
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.43A 2a3cB-1d2kA:
65.4
2a3cB-1d2kA:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 9 TYR A  43
PHE A  71
GLY A 130
ASP A 169
GLU A 171
TYR A 239
TRP A 378
None
0.92A 2uy4A-1d2kA:
19.8
2uy4A-1d2kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 11 TYR A  43
PHE A  71
GLY A 130
ASP A 169
GLU A 171
TYR A 239
TRP A 378
None
1.06A 2xtkA-1d2kA:
21.0
2xtkA-1d2kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 10 TYR A  43
PHE A  71
GLY A 130
ASP A 169
GLU A 171
TYR A 239
TRP A 378
None
0.95A 2xtkB-1d2kA:
21.3
2xtkB-1d2kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARQ_A_DM5A606_1
(CHITINASE A)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 6 TRP A 131
ASP A 240
TRP A 245
ARG A 295
None
0.86A 3arqA-1d2kA:
40.6
3arqA-1d2kA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 7 GLY A 215
ASP A 240
TRP A 245
ARG A 295
None
0.60A 3arrA-1d2kA:
41.1
3arrA-1d2kA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 7 TRP A 131
ASP A 240
TRP A 245
ARG A 295
None
0.89A 3arrA-1d2kA:
41.1
3arrA-1d2kA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 7 GLY A 215
ASP A 240
TRP A 245
ARG A 295
None
0.56A 3aruA-1d2kA:
40.7
3aruA-1d2kA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
11 / 11 TYR A  43
PHE A  71
GLY A 130
TRP A 131
ASP A 169
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
TRP A 378
None
0.48A 3g6mA-1d2kA:
62.1
3g6mA-1d2kA:
51.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA427_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 5 TRP A 131
TYR A 172
MET A 237
ASP A 240
TRP A 245
None
0.62A 3g6mA-1d2kA:
62.1
3g6mA-1d2kA:
51.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 6 PHE A 163
TYR A  69
VAL A 105
THR A  89
None
1.36A 3ltwA-1d2kA:
undetectable
3ltwA-1d2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 10 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.33A 3lxiA-1d2kA:
0.0
3lxiA-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 12 PHE A 297
PHE A 307
THR A 300
GLY A 250
GLY A 302
None
1.09A 3tegA-1d2kA:
undetectable
3tegA-1d2kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
8 / 11 PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
TYR A 293
TRP A 378
None
0.80A 3wqvA-1d2kA:
44.0
3wqvA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
9 / 11 PHE A  71
GLY A 130
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
ARG A 295
TRP A 378
None
0.54A 3wqvA-1d2kA:
44.0
3wqvA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
6 / 11 PHE A  71
GLY A 130
TRP A 131
ASP A 169
GLU A 171
TYR A 293
None
1.02A 3wqvA-1d2kA:
44.0
3wqvA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 11 PHE A  71
GLY A 130
TRP A 131
GLU A 171
ASP A 240
TYR A 293
ARG A 295
None
0.81A 3wqvA-1d2kA:
44.0
3wqvA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
8 / 11 PHE A  71
GLY A 130
ASP A 169
GLU A 171
MET A 237
TYR A 239
TYR A 293
TRP A 378
None
0.81A 3wqwA-1d2kA:
43.9
3wqwA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
9 / 11 PHE A  71
GLY A 130
GLU A 171
MET A 237
TYR A 239
ASP A 240
TYR A 293
ARG A 295
TRP A 378
None
0.55A 3wqwA-1d2kA:
43.9
3wqwA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
6 / 11 PHE A  71
GLY A 130
TRP A 131
ASP A 169
GLU A 171
TYR A 293
None
1.00A 3wqwA-1d2kA:
43.9
3wqwA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 11 PHE A  71
GLY A 130
TRP A 131
GLU A 171
ASP A 240
TYR A 293
ARG A 295
None
0.79A 3wqwA-1d2kA:
43.9
3wqwA-1d2kA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 9 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.34A 4c9kA-1d2kA:
0.0
4c9kA-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 10 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.31A 4c9nB-1d2kA:
0.0
4c9nB-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 9 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.31A 4c9pA-1d2kA:
0.0
4c9pA-1d2kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 10 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.29A 4c9pB-1d2kA:
0.0
4c9pB-1d2kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)
1d2k CHITINASE 1
(Coccidioides
immitis)
3 / 3 CYH A 108
ASN A  55
LYS A  91
None
1.00A 4k50A-1d2kA:
0.0
4k50A-1d2kA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 12 SER A 314
ASP A 324
ASN A 317
GLY A 243
PHE A 297
None
0.96A 4obwC-1d2kA:
undetectable
4obwC-1d2kA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 11 ALA A 360
GLY A 361
GLU A 365
GLY A 374
TRP A 377
None
1.24A 5ayfA-1d2kA:
undetectable
5ayfA-1d2kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 6 TRP A 245
SER A 242
PRO A 266
PHE A 241
None
1.21A 5b8iA-1d2kA:
0.2
5b8iA-1d2kA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
7 / 8 PHE A  71
GLY A 130
GLU A 171
TYR A 239
ASP A 240
ARG A 295
TRP A 378
None
0.59A 5gqbA-1d2kA:
43.6
5gqbA-1d2kA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
6 / 8 PHE A  71
GLY A 130
TRP A 131
GLU A 171
ASP A 240
ARG A 295
None
0.99A 5gqbA-1d2kA:
43.6
5gqbA-1d2kA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 4 THR A 209
LEU A 207
HIS A  66
GLY A 165
None
1.06A 5gwyA-1d2kA:
undetectable
5gwyA-1d2kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)
1d2k CHITINASE 1
(Coccidioides
immitis)
4 / 8 PRO A  56
TYR A  93
SER A  83
ASN A  46
None
1.13A 5l1fA-1d2kA:
1.3
5l1fB-1d2kA:
undetectable
5l1fA-1d2kA:
19.63
5l1fB-1d2kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
1d2k CHITINASE 1
(Coccidioides
immitis)
5 / 10 LEU A 157
THR A 153
GLY A  78
ILE A  74
ILE A 166
None
1.22A 6ebpB-1d2kA:
undetectable
6ebpB-1d2kA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
1d2k CHITINASE 1
(Coccidioides
immitis)
3 / 3 THR A 209
GLU A 171
ASN A 235
None
0.83A 6nj9K-1d2kA:
undetectable
6nj9K-1d2kA:
21.28