SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		4 / 5 THR A 558
THR A 653
GLU A 614
HIS A 554
 MG  A  99 ( 3.2A)
None
None
ANP  A   1 (-4.7A)
 1.20A 1d4fB-1d2nA:
0.0		 1d4fB-1d2nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 PHE A 737
LEU A 688
LEU A 685
 None
 0.62A 1mx1E-1d2nA:
undetectable		 1mx1E-1d2nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		5 / 12 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.17A 1xzxX-1d2nA:
0.0		 1xzxX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		5 / 12 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.20A 1y0xX-1d2nA:
0.1		 1y0xX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		4 / 7 LEU A 690
LEU A 691
ARG A 733
SER A 725
 None
 0.98A 2hc4A-1d2nA:
0.0		 2hc4A-1d2nA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 ARG A 615
ASP A 579
ASP A 612
 None
None
ANP  A   1 ( 4.3A)
 0.81A 3jayA-1d2nA:
0.0		 3jayA-1d2nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 ARG A 615
ASP A 579
ASP A 612
 None
None
ANP  A   1 ( 4.3A)
 0.91A 3jb2A-1d2nA:
0.0		 3jb2A-1d2nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		4 / 6 VAL A 522
LEU A 649
ILE A 575
LEU A 526
 ANP  A   1 (-4.4A)
None
None
None
 0.99A 3kk6A-1d2nA:
undetectable		 3kk6A-1d2nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 LEU A 718
TRP A 518
GLY A 519
 None
ANP  A   1 (-4.9A)
None
 0.72A 3l35A-1d2nA:
0.0
3l35H-1d2nA:
undetectable		 3l35A-1d2nA:
12.96
3l35H-1d2nA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 LEU A 718
TRP A 518
GLY A 519
 None
ANP  A   1 (-4.9A)
None
 0.77A 3l35B-1d2nA:
undetectable
3l35K-1d2nA:
undetectable		 3l35B-1d2nA:
12.96
3l35K-1d2nA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		4 / 8 ILE A 722
ILE A 702
PHE A 737
GLU A 686
 None
 0.87A 3ua5A-1d2nA:
0.0		 3ua5A-1d2nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 VAL A 706
GLY A 708
LYS A 710
 None
 0.75A 4k50A-1d2nA:
undetectable		 4k50A-1d2nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 VAL A 706
GLY A 708
LYS A 710
 None
 0.73A 4k50E-1d2nA:
0.0		 4k50E-1d2nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 VAL A 706
GLY A 708
LYS A 710
 None
 0.74A 4k50I-1d2nA:
0.0		 4k50I-1d2nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		5 / 12 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.15A 4lnwA-1d2nA:
0.4		 4lnwA-1d2nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		5 / 12 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.15A 4lnxA-1d2nA:
0.3		 4lnxA-1d2nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 LYS A 707
LEU A 741
ILE A 678
 None
 0.77A 5kc4A-1d2nA:
undetectable		 5kc4A-1d2nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 HIS A 554
SER A 555
LYS A 557
 ANP  A   1 (-4.7A)
ANP  A   1 (-4.1A)
ANP  A   1 (-2.6A)
 0.61A 5os7A-1d2nA:
0.0		 5os7A-1d2nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN
(Cricetulus
griseus) 		3 / 3 HIS A 554
SER A 555
LYS A 557
 ANP  A   1 (-4.7A)
ANP  A   1 (-4.1A)
ANP  A   1 (-2.6A)
 0.61A 6gmdB-1d2nA:
0.0		 6gmdB-1d2nA:
22.64