SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		3 / 3 ASP B  40
PHE B 147
ARG B  43
 None
 0.67A 2a3aA-1d2zB:
undetectable		 2a3aA-1d2zB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 132
LEU B 141
ALA B 144
ILE B  47
LEU B  33
 None
 1.16A 2jn3A-1d2zB:
0.0		 2jn3A-1d2zB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 MET B  65
ILE B  61
TRP B 117
GLU B 125
 None
 1.36A 2nsiA-1d2zB:
undetectable
2nsiB-1d2zB:
undetectable		 2nsiA-1d2zB:
16.94
2nsiB-1d2zB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 TRP B 117
GLU B 125
MET B  65
ILE B  61
 None
 1.38A 2nsiA-1d2zB:
0.0
2nsiB-1d2zB:
undetectable		 2nsiA-1d2zB:
16.94
2nsiB-1d2zB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 MET B  65
ILE B  61
TRP B 117
GLU B 125
 None
 1.34A 2nsiC-1d2zB:
undetectable
2nsiD-1d2zB:
0.0		 2nsiC-1d2zB:
16.94
2nsiD-1d2zB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 TRP B 117
GLU B 125
MET B  65
ILE B  61
 None
 1.33A 2nsiC-1d2zB:
0.0
2nsiD-1d2zB:
0.0		 2nsiC-1d2zB:
16.94
2nsiD-1d2zB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d2z DEATH DOMAIN OF
PELLE
(Drosophila
melanogaster) 		5 / 12 LEU A 101
LEU A 104
PHE A 105
LEU A 108
ILE A  34
 None
 1.12A 2pnjA-1d2zA:
undetectable		 2pnjA-1d2zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B  76
ALA B 139
ALA B 145
VAL B 148
GLY B 130
 None
 0.93A 3c6gB-1d2zB:
undetectable		 3c6gB-1d2zB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 TRP B 117
GLU B 125
MET B  65
ILE B  61
 None
 1.36A 3e7gA-1d2zB:
0.0
3e7gB-1d2zB:
0.0		 3e7gA-1d2zB:
17.43
3e7gB-1d2zB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 MET B  65
ILE B  61
TRP B 117
GLU B 125
 None
 1.45A 3e7gC-1d2zB:
0.0
3e7gD-1d2zB:
0.0		 3e7gC-1d2zB:
17.43
3e7gD-1d2zB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1d2z DEATH DOMAIN OF
PELLE
(Drosophila
melanogaster) 		4 / 8 ARG A  35
ALA A  33
ILE A  34
ASN A  95
 None
 0.99A 3fxrA-1d2zA:
undetectable		 3fxrA-1d2zA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1d2z DEATH DOMAIN OF
PELLE
(Drosophila
melanogaster) 		3 / 3 ARG A  78
ASP A  67
GLN A  93
 None
 0.84A 3lcvB-1d2zA:
undetectable		 3lcvB-1d2zA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 141
ALA B 145
LEU B 133
LEU B 132
ILE B  60
 None
 1.25A 3olsB-1d2zB:
undetectable		 3olsB-1d2zB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 4 LEU B  33
LEU B 135
GLN B 111
GLU B 116
 None
 0.82A 4i41A-1d2zB:
undetectable		 4i41A-1d2zB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1d2z DEATH DOMAIN OF
PELLE
(Drosophila
melanogaster) 		3 / 3 LEU A  36
LEU A  45
ASN A  88
 None
 0.67A 4otwA-1d2zA:
undetectable		 4otwA-1d2zA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 133
VAL B 137
PRO B 158
THR B 157
ARG B 160
 None
 1.26A 4q15A-1d2zB:
undetectable		 4q15A-1d2zB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 133
VAL B 137
PRO B 158
THR B 157
ARG B 160
 None
 1.31A 4q15B-1d2zB:
undetectable		 4q15B-1d2zB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1d2z DEATH DOMAIN OF
PELLE
(Drosophila
melanogaster) 		4 / 7 LEU A  49
LEU A  58
LEU A  45
ALA A 113
 None
 0.67A 4z90F-1d2zA:
undetectable
4z90G-1d2zA:
undetectable
4z90H-1d2zA:
undetectable
4z90J-1d2zA:
undetectable		 4z90F-1d2zA:
18.18
4z90G-1d2zA:
18.18
4z90H-1d2zA:
18.18
4z90J-1d2zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		4 / 7 ILE B 114
TRP B  54
ASP B  49
LYS B  46
 None
 1.26A 5nr3A-1d2zB:
0.0		 5nr3A-1d2zB:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 133
VAL B 137
PRO B 158
THR B 157
ARG B 160
 None
 1.25A 5xipA-1d2zB:
undetectable		 5xipA-1d2zB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1d2z DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 LEU B 133
VAL B 137
PRO B 158
THR B 157
ARG B 160
 None
 1.29A 5xipD-1d2zB:
undetectable		 5xipD-1d2zB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1d2z DEATH DOMAIN OF
PELLE
DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 GLY A  92
GLY A  91
GLN A  71
VAL A  62
PRO B 165
 None
 0.91A 6gneA-1d2zA:
undetectable		 6gneA-1d2zA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1d2z DEATH DOMAIN OF
PELLE
DEATH DOMAIN OF TUBE
(Drosophila
melanogaster) 		5 / 12 GLY A  92
GLY A  91
GLN A  71
VAL A  62
PRO B 165
 None
 0.91A 6gneB-1d2zA:
undetectable		 6gneB-1d2zA:
13.57