SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A 146
PHE A 232
LEU A 152
LEU A 242
HIS A 240
 None
 1.19A 1e7wB-1d3yA:
undetectable		 1e7wB-1d3yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 175
LEU A 221
SER A 146
LEU A 236
ILE A 193
 None
 0.99A 1fmlA-1d3yA:
0.0		 1fmlA-1d3yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  79
LEU A  83
LEU A  90
 None
 0.62A 1mz9C-1d3yA:
undetectable		 1mz9C-1d3yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A 118
PHE A 113
ASN A 121
ILE A 123
 NA  A 370 ( 3.7A)
None
None
None
 1.15A 1yc2D-1d3yA:
2.1		 1yc2D-1d3yA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 148
ILE A 217
LEU A 152
LEU A 184
LEU A 186
 None
 1.28A 2a15A-1d3yA:
undetectable		 2a15A-1d3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 281
ARG A 282
TYR A 255
PHE A 318
 None
 1.13A 2ajvH-1d3yA:
undetectable
2ajvL-1d3yA:
undetectable		 2ajvH-1d3yA:
22.07
2ajvL-1d3yA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 SER A 146
LEU A 236
ILE A 177
GLU A 197
LEU A 262
 None
None
None
MG  A 371 (-2.5A)
None
 1.01A 2v0mB-1d3yA:
0.0		 2v0mB-1d3yA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		6 / 12 ALA A 339
ASP A 249
ASP A 251
GLY A 285
ILE A 292
ILE A 291
 None
MG  A 371 (-3.2A)
MG  A 371 ( 4.1A)
None
None
None
 1.19A 3s54B-1d3yA:
undetectable		 3s54B-1d3yA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 251
ASP A 249
ASP A 305
GLU A 303
 MG  A 371 ( 4.1A)
MG  A 371 (-3.2A)
None
None
 1.05A 4feuD-1d3yA:
undetectable		 4feuD-1d3yA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A 286
LEU A 344
VAL A 352
PHE A 247
 None
 1.01A 4lb0B-1d3yA:
undetectable		 4lb0B-1d3yA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 286
GLU A 197
TYR A 259
TYR A 255
SER A 146
 None
MG  A 371 (-2.5A)
None
None
None
 1.31A 4xudA-1d3yA:
undetectable		 4xudA-1d3yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 105
ARG A 134
GLY A 138
GLU A 135
 None
 1.19A 5btiA-1d3yA:
0.0
5btiB-1d3yA:
6.1		 5btiA-1d3yA:
20.48
5btiB-1d3yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 105
ARG A 134
GLY A 138
GLU A 135
 None
 1.14A 5btiC-1d3yA:
undetectable
5btiD-1d3yA:
6.0		 5btiC-1d3yA:
20.48
5btiD-1d3yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 196
LEU A 218
GLY A 150
PRO A 151
LEU A 344
 None
 1.16A 5ienA-1d3yA:
undetectable		 5ienA-1d3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1d3y DNA TOPOISOMERASE VI
A SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 249
ASP A 251
GLY A 285
ILE A 292
ILE A 291
 MG  A 371 (-3.2A)
MG  A 371 ( 4.1A)
None
None
None
 0.93A 6dh3A-1d3yA:
undetectable		 6dh3A-1d3yA:
13.59