SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 GLU A  34
LEU A  31
ASP A  29
GLY A 299
 None
 0.87A 1n13D-1d4eA:
0.0
1n13E-1d4eA:
0.0		 1n13D-1d4eA:
13.78
1n13E-1d4eA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 LEU A  31
ASP A  29
GLY A 299
GLU A  34
 None
 0.87A 1n13A-1d4eA:
0.0
1n13F-1d4eA:
0.0		 1n13A-1d4eA:
8.91
1n13F-1d4eA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 GLU A  34
LEU A  31
ASP A  29
GLY A 299
 None
 0.91A 1n13H-1d4eA:
0.0
1n13K-1d4eA:
0.0		 1n13H-1d4eA:
13.78
1n13K-1d4eA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 LEU A  31
ASP A  29
GLY A 299
GLU A  34
 None
 0.89A 1n13G-1d4eA:
0.0
1n13J-1d4eA:
0.0		 1n13G-1d4eA:
8.91
1n13J-1d4eA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ILE A 375
VAL A 440
LEU A 488
VAL A 464
ILE A 385
 None
 1.06A 1oipA-1d4eA:
undetectable		 1oipA-1d4eA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 ILE A 408
PRO A 500
PHE A 332
ALA A 363
 None
 1.07A 1oniD-1d4eA:
0.0
1oniE-1d4eA:
0.0		 1oniD-1d4eA:
13.69
1oniE-1d4eA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 348
LEU A 345
GLY A 342
GLY A 313
 None
None
None
FAD  A 600 (-3.5A)
 0.81A 1rukH-1d4eA:
undetectable
1rukL-1d4eA:
undetectable		 1rukH-1d4eA:
16.78
1rukL-1d4eA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.80A 1usqB-1d4eA:
0.0		 1usqB-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.83A 1usqC-1d4eA:
0.0		 1usqC-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.81A 1usqD-1d4eA:
undetectable		 1usqD-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.83A 1usqE-1d4eA:
0.0		 1usqE-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.82A 1usqF-1d4eA:
0.0		 1usqF-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 PHE A 470
ARG A 380
ASN A 396
 None
 0.59A 1xzxX-1d4eA:
0.0		 1xzxX-1d4eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ASN A 388
LYS A 412
GLU A 459
GLY A 391
 None
 0.65A 1ykiA-1d4eA:
undetectable
1ykiB-1d4eA:
0.0		 1ykiA-1d4eA:
17.83
1ykiB-1d4eA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ASN A 388
LYS A 412
GLU A 459
GLY A 391
 None
 0.65A 1ykiA-1d4eA:
undetectable
1ykiB-1d4eA:
undetectable		 1ykiA-1d4eA:
17.83
1ykiB-1d4eA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ASN A 388
LYS A 412
GLU A 459
GLY A 391
 None
 0.65A 1ykiC-1d4eA:
0.0
1ykiD-1d4eA:
undetectable		 1ykiC-1d4eA:
17.83
1ykiD-1d4eA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ASN A 388
LYS A 412
GLU A 459
GLY A 391
 None
 0.64A 1ykiC-1d4eA:
0.0
1ykiD-1d4eA:
undetectable		 1ykiC-1d4eA:
17.83
1ykiD-1d4eA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 GLY A 162
GLU A 155
ASN A 163
 FAD  A 600 (-3.2A)
FAD  A 600 (-2.7A)
FAD  A 600 (-3.6A)
 0.67A 1zq9A-1d4eA:
0.4		 1zq9A-1d4eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 8 TYR A 434
GLY A 169
GLY A 251
ALA A 430
ALA A 250
 HEM  A 601 (-4.3A)
FUM  A 700 ( 3.0A)
None
HEM  A 601 ( 3.8A)
None
 1.31A 2ej3C-1d4eA:
undetectable		 2ej3C-1d4eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ALA A 167
GLY A 162
GLY A 161
VAL A 554
ILE A 550
 FAD  A 600 (-3.7A)
FAD  A 600 (-3.2A)
None
None
FAD  A 600 (-4.3A)
 0.79A 2fxeA-1d4eA:
undetectable		 2fxeA-1d4eA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.77A 2jkjA-1d4eA:
0.0		 2jkjA-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.77A 2jkjB-1d4eA:
0.0		 2jkjB-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.77A 2jkjC-1d4eA:
0.0		 2jkjC-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.77A 2jkjE-1d4eA:
undetectable		 2jkjE-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.78A 2jklB-1d4eA:
0.0		 2jklB-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 PRO A 160
GLY A 134
ILE A 130
GLY A 132
 None
FAD  A 600 (-3.1A)
None
FAD  A 600 (-3.4A)
 0.79A 2jklE-1d4eA:
undetectable		 2jklE-1d4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ALA A 532
THR A 536
ALA A 353
ALA A 351
ILE A 131
 None
None
None
None
FAD  A 600 ( 4.7A)
 0.99A 2nyrA-1d4eA:
2.6		 2nyrA-1d4eA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ILE A 553
GLY A 161
GLY A 135
ASN A 163
PRO A 338
 FAD  A 600 (-3.7A)
None
FAD  A 600 (-4.1A)
FAD  A 600 (-3.6A)
None
 1.18A 2okcB-1d4eA:
2.1		 2okcB-1d4eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		6 / 12 LEU A 509
GLY A 313
ALA A 312
ILE A 130
VAL A 517
ILE A 310
 None
FAD  A 600 (-3.5A)
FAD  A 600 (-3.4A)
None
None
None
 1.49A 2q63A-1d4eA:
undetectable		 2q63A-1d4eA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		6 / 12 LEU A 509
GLY A 313
ALA A 312
ILE A 130
VAL A 517
ILE A 310
 None
FAD  A 600 (-3.5A)
FAD  A 600 (-3.4A)
None
None
None
 1.49A 2q64B-1d4eA:
undetectable		 2q64B-1d4eA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 LEU A 488
GLN A 478
LEU A 496
VAL A 440
VAL A 387
 None
 1.35A 2qd4B-1d4eA:
undetectable		 2qd4B-1d4eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 GLU A  34
LEU A  31
ASP A  29
GLY A 299
 None
 0.85A 2qqdB-1d4eA:
0.0
2qqdC-1d4eA:
0.0		 2qqdB-1d4eA:
13.81
2qqdC-1d4eA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 GLY A 135
GLY A 313
GLU A 534
VAL A 347
ILE A 310
 FAD  A 600 (-4.1A)
FAD  A 600 (-3.5A)
FAD  A 600 (-3.2A)
None
None
 1.20A 2wa2A-1d4eA:
3.1		 2wa2A-1d4eA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 6 GLY A 508
GLY A 537
GLY A 538
GLY A 507
GLY A 541
 None
 1.17A 3bogA-1d4eA:
0.0
3bogC-1d4eA:
0.0		 3bogA-1d4eA:
undetectable
3bogC-1d4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 10 VAL A 291
ALA A 305
ILE A 526
PRO A 525
ILE A 280
 None
 1.14A 3clbD-1d4eA:
0.0		 3clbD-1d4eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 168
GLY A 546
PRO A 365
THR A 366
 FUM  A 700 (-3.8A)
FUM  A 700 (-3.6A)
None
None
 0.75A 3el9A-1d4eA:
undetectable		 3el9A-1d4eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 GLY A 533
VAL A 535
ILE A 511
ALA A 136
VAL A 309
 FAD  A 600 (-3.5A)
None
None
FAD  A 600 (-3.3A)
None
 1.00A 3fpjA-1d4eA:
3.0		 3fpjA-1d4eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 10 VAL A 291
ALA A 305
ILE A 526
PRO A 525
ILE A 280
 None
 1.12A 3hbbD-1d4eA:
0.0		 3hbbD-1d4eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 LEU A 418
ARG A 401
SER A 427
GLY A 169
 None
FUM  A 700 (-3.2A)
None
FUM  A 700 ( 3.0A)
 0.98A 3hcnA-1d4eA:
undetectable		 3hcnA-1d4eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ILE A 310
VAL A 309
GLY A 533
ALA A 531
ILE A 550
 None
None
FAD  A 600 (-3.5A)
None
FAD  A 600 (-4.3A)
 0.85A 3mb5A-1d4eA:
3.1		 3mb5A-1d4eA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 THR A 195
LEU A 545
ARG A 401
ASN A 543
LEU A 211
 None
None
FUM  A 700 (-3.2A)
None
None
 1.32A 3ndvA-1d4eA:
0.0
3ndvB-1d4eA:
0.0		 3ndvA-1d4eA:
21.61
3ndvB-1d4eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 LEU A 211
THR A 195
LEU A 545
ARG A 401
ASN A 543
 None
None
None
FUM  A 700 (-3.2A)
None
 1.37A 3ndvA-1d4eA:
0.0
3ndvB-1d4eA:
0.0		 3ndvA-1d4eA:
21.61
3ndvB-1d4eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ASN A 392
ARG A 389
ILE A 385
ALA A 466
TYR A 467
 None
 1.17A 3ohtA-1d4eA:
0.0
3ohtB-1d4eA:
0.0		 3ohtA-1d4eA:
19.93
3ohtB-1d4eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 GLY A 313
ASP A 343
VAL A 347
ILE A 130
 FAD  A 600 (-3.5A)
FAD  A 600 (-4.4A)
None
None
 0.61A 3t3cA-1d4eA:
undetectable		 3t3cA-1d4eA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.05A 3u9fF-1d4eA:
0.0		 3u9fF-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.12A 3u9fG-1d4eA:
0.0		 3u9fG-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.16A 3u9fL-1d4eA:
0.0		 3u9fL-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 PHE A  90
CYH A  84
HIS A  88
 HEM  A 601 (-4.3A)
HEM  A 601 (-1.9A)
HEM  A 601 (-3.2A)
 1.11A 3u9fS-1d4eA:
0.0		 3u9fS-1d4eA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A 424
GLY A 381
GLU A 377
ASN A 396
TYR A 467
 None
None
FUM  A 700 (-4.6A)
None
None
 1.20A 4e47A-1d4eA:
undetectable		 4e47A-1d4eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A 424
GLY A 381
GLU A 377
ASN A 396
TYR A 467
 None
None
FUM  A 700 (-4.6A)
None
None
 1.22A 4e47B-1d4eA:
undetectable		 4e47B-1d4eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A  65
TRP A 261
LEU A 153
GLY A 162
ALA A 136
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-3.3A)
 1.30A 4fogD-1d4eA:
undetectable		 4fogD-1d4eA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 GLY A 237
ILE A 398
ASN A 396
MET A 506
 None
 1.06A 4g0vA-1d4eA:
undetectable		 4g0vA-1d4eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 GLY A 237
ASN A 241
GLN A 362
MET A 506
 None
 1.31A 4g0vB-1d4eA:
1.2		 4g0vB-1d4eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 167
GLY A 161
VAL A 554
ILE A 550
 FAD  A 600 (-3.7A)
None
None
FAD  A 600 (-4.3A)
 0.76A 4ll3A-1d4eA:
undetectable		 4ll3A-1d4eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 167
GLY A 162
VAL A 554
ILE A 550
 FAD  A 600 (-3.7A)
FAD  A 600 (-3.2A)
None
FAD  A 600 (-4.3A)
 0.75A 4ll3A-1d4eA:
undetectable		 4ll3A-1d4eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 GLY A 313
ALA A 312
ASP A 343
VAL A 347
ILE A 130
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.4A)
FAD  A 600 (-4.4A)
None
None
 1.10A 4njtD-1d4eA:
undetectable		 4njtD-1d4eA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 ALA A 515
ILE A 131
GLY A 137
ALA A 136
VAL A 535
 None
FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.3A)
None
 1.19A 4r1zA-1d4eA:
undetectable		 4r1zA-1d4eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 5 ILE A 303
VAL A 129
ILE A 131
VAL A 291
 None
None
FAD  A 600 ( 4.7A)
None
 0.74A 4xdtA-1d4eA:
0.0		 4xdtA-1d4eA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 GLU A 296
LYS A 294
ASN A 274
 None
 0.99A 4y1dA-1d4eA:
0.0
4y1dD-1d4eA:
undetectable		 4y1dA-1d4eA:
17.09
4y1dD-1d4eA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 ILE A 408
PHE A 394
TYR A 417
ALA A 499
GLU A 497
 None
 1.25A 4yp2B-1d4eA:
undetectable		 4yp2B-1d4eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 ALA A 532
GLY A 557
ALA A 140
GLY A 137
 None
 0.69A 4zjzA-1d4eA:
undetectable		 4zjzA-1d4eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 8 ALA A 560
VAL A 309
GLY A 557
ALA A 139
GLY A 137
 None
 1.43A 4zjzB-1d4eA:
1.1		 4zjzB-1d4eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 VAL A 278
GLN A 114
LEU A 292
GLU A 282
 None
 1.05A 4zphA-1d4eA:
0.0
4zphB-1d4eA:
0.0		 4zphA-1d4eA:
21.40
4zphB-1d4eA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 GLU A 155
ASP A 146
ARG A 267
GLY A 268
 FAD  A 600 (-2.7A)
None
None
None
 0.92A 5cdnC-1d4eA:
undetectable
5cdnD-1d4eA:
undetectable		 5cdnC-1d4eA:
21.36
5cdnD-1d4eA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 6 GLU A 155
ASP A 146
ARG A 267
GLY A 268
 FAD  A 600 (-2.7A)
None
None
None
 0.94A 5cdnT-1d4eA:
0.0
5cdnU-1d4eA:
undetectable		 5cdnT-1d4eA:
21.36
5cdnU-1d4eA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 ILE A 408
PHE A 394
TYR A 417
ALA A 499
GLU A 497
 None
 1.25A 5cf9B-1d4eA:
undetectable		 5cf9B-1d4eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 ALA A 340
GLU A 155
GLY A 313
GLY A 344
 None
FAD  A 600 (-2.7A)
FAD  A 600 (-3.5A)
FAD  A 600 ( 4.6A)
 0.85A 5e26A-1d4eA:
undetectable
5e26B-1d4eA:
0.0		 5e26A-1d4eA:
20.41
5e26B-1d4eA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 GLU A 155
GLY A 313
GLY A 344
ALA A 340
 FAD  A 600 (-2.7A)
FAD  A 600 (-3.5A)
FAD  A 600 ( 4.6A)
None
 0.88A 5e26C-1d4eA:
0.0
5e26D-1d4eA:
0.0		 5e26C-1d4eA:
20.41
5e26D-1d4eA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 8 VAL A 256
ALA A 257
GLY A 161
GLY A 137
 None
 0.83A 5e26C-1d4eA:
undetectable
5e26D-1d4eA:
undetectable		 5e26C-1d4eA:
20.41
5e26D-1d4eA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 7 VAL A 464
THR A 463
LEU A 449
VAL A 455
 None
 0.94A 5e4dA-1d4eA:
0.0
5e4dB-1d4eA:
0.0		 5e4dA-1d4eA:
16.49
5e4dB-1d4eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 HIS A 504
GLY A 546
HIS A 540
ASP A 552
LEU A 211
 FAD  A 600 (-3.8A)
FUM  A 700 (-3.6A)
None
None
None
 1.21A 5eeiA-1d4eA:
undetectable		 5eeiA-1d4eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 HIS A 504
GLY A 546
HIS A 540
ASP A 552
LEU A 211
 FAD  A 600 (-3.8A)
FUM  A 700 (-3.6A)
None
None
None
 1.23A 5eeiB-1d4eA:
undetectable		 5eeiB-1d4eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 GLY A 313
ALA A 312
ASP A 343
VAL A 347
ILE A 130
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.4A)
FAD  A 600 (-4.4A)
None
None
 0.98A 5kr0B-1d4eA:
undetectable		 5kr0B-1d4eA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 11 ILE A 131
VAL A 277
ASP A 270
ILE A 303
ALA A 305
 FAD  A 600 ( 4.7A)
FAD  A 600 (-4.2A)
None
None
None
 1.07A 5lg3A-1d4eA:
undetectable		 5lg3A-1d4eA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		6 / 12 ILE A 375
VAL A 440
ILE A 424
LEU A 488
VAL A 464
ILE A 385
 None
 1.45A 5mueA-1d4eA:
0.2		 5mueA-1d4eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 GLY A 170
HIS A 244
ILE A 431
ALA A 430
VAL A 379
 FAD  A 600 (-4.3A)
None
None
HEM  A 601 ( 3.8A)
None
 1.07A 5n0sA-1d4eA:
0.0		 5n0sA-1d4eA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 GLY A 170
HIS A 244
ILE A 431
ALA A 430
VAL A 379
 FAD  A 600 (-4.3A)
None
None
HEM  A 601 ( 3.8A)
None
 1.08A 5n0tA-1d4eA:
undetectable		 5n0tA-1d4eA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 GLY A 170
HIS A 244
ILE A 431
ALA A 430
VAL A 379
 FAD  A 600 (-4.3A)
None
None
HEM  A 601 ( 3.8A)
None
 1.12A 5n0xA-1d4eA:
undetectable		 5n0xA-1d4eA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ILE A 131
ILE A  65
ALA A 257
LEU A 138
ALA A 139
 FAD  A 600 ( 4.7A)
None
None
None
None
 1.23A 5oy02-1d4eA:
undetectable		 5oy02-1d4eA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 10 ILE A 131
ILE A  65
ALA A 257
LEU A 138
ALA A 139
 FAD  A 600 ( 4.7A)
None
None
None
None
 1.31A 5zjiB-1d4eA:
0.0		 5zjiB-1d4eA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		3 / 3 HIS A 364
HIS A 503
ARG A 544
 FUM  A 700 (-4.7A)
FUM  A 700 ( 4.1A)
FUM  A 700 ( 3.0A)
 0.47A 6b58A-1d4eA:
32.3		 6b58A-1d4eA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 9 ALA A 167
VAL A 256
ALA A 257
VAL A 554
GLY A 134
 FAD  A 600 (-3.7A)
None
None
None
FAD  A 600 (-3.1A)
 1.24A 6bklA-1d4eA:
undetectable
6bklB-1d4eA:
undetectable
6bklC-1d4eA:
undetectable
6bklD-1d4eA:
undetectable		 6bklA-1d4eA:
3.84
6bklB-1d4eA:
3.84
6bklC-1d4eA:
3.84
6bklD-1d4eA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		5 / 12 ALA A 167
GLY A 162
GLY A 161
VAL A 554
ILE A 550
 FAD  A 600 (-3.7A)
FAD  A 600 (-3.2A)
None
None
FAD  A 600 (-4.3A)
 0.79A 6dj1A-1d4eA:
undetectable		 6dj1A-1d4eA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE
(Shewanella
oneidensis) 		4 / 4 GLN A 362
THR A 505
HIS A 337
LEU A 166
 None
None
FAD  A 600 ( 4.6A)
HEM  A 601 (-4.1A)
 1.35A 6f3nB-1d4eA:
2.6		 6f3nB-1d4eA:
22.82