SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1d4o NADP(H)
TRANSHYDROGENASE
(Bos
taurus) 		5 / 6 ALA A  36
LYS A 168
ASP A 172
ALA A 173
LEU A  12
 NAP  A 201 (-3.5A)
None
None
None
None
 1.35A 1iwhA-1d4oA:
undetectable		 1iwhA-1d4oA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1d4o NADP(H)
TRANSHYDROGENASE
(Bos
taurus) 		5 / 6 LYS A 168
LYS A 169
ASP A 172
ALA A 173
LEU A  12
 None
 1.21A 1iwhA-1d4oA:
undetectable		 1iwhA-1d4oA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1d4o NADP(H)
TRANSHYDROGENASE
(Bos
taurus) 		4 / 8 ARG A  66
GLY A  69
PRO A  29
GLY A 105
 NAP  A 201 (-2.7A)
None
None
NAP  A 201 (-4.0A)
 0.79A 2y6rB-1d4oA:
2.7		 2y6rB-1d4oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1d4o NADP(H)
TRANSHYDROGENASE
(Bos
taurus) 		5 / 11 ILE A  42
ILE A  60
ILE A  84
VAL A  80
VAL A  85
 None
 0.90A 3kw4A-1d4oA:
0.0		 3kw4A-1d4oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1d4o NADP(H)
TRANSHYDROGENASE
(Bos
taurus) 		5 / 10 GLY A 105
GLY A  30
LEU A 174
ILE A  27
LEU A 102
 NAP  A 201 (-4.0A)
NAP  A 201 (-3.2A)
None
None
None
 0.99A 5vm8B-1d4oA:
2.4		 5vm8B-1d4oA:
22.09