SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		5 / 10 GLY A  18
ASP A 108
ILE A 109
ILE A  81
ALA A 120
 None
 1.03A 1sh9B-1d5cA:
undetectable		 1sh9B-1d5cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		4 / 7 ILE A  44
GLY A  45
LEU A  76
PHE A  73
 None
 0.90A 2vctD-1d5cA:
undetectable		 2vctD-1d5cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		4 / 6 THR A 168
LEU A  14
VAL A 122
VAL A  90
 None
 0.98A 2z97A-1d5cA:
undetectable		 2z97A-1d5cA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		5 / 9 VAL A  90
GLY A 123
GLN A  70
ASN A 124
GLY A  23
 None
None
None
GDP  A 201 (-3.3A)
GDP  A 201 (-3.4A)
 1.33A 3kmoA-1d5cA:
0.0		 3kmoA-1d5cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		5 / 9 THR A 103
THR A 102
ASN A 101
TYR A  91
ASP A  92
 None
 1.05A 3sfuA-1d5cA:
undetectable		 3sfuA-1d5cA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		4 / 8 THR A 168
LEU A  14
VAL A 122
VAL A  90
 None
 1.02A 4l4bA-1d5cA:
0.0		 4l4bA-1d5cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		3 / 3 PHE A  16
ILE A  27
ASP A  92
 None
 0.48A 5cswA-1d5cA:
0.0		 5cswA-1d5cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		3 / 3 PHE A  16
ILE A  27
ASP A  92
 None
 0.53A 5cswB-1d5cA:
0.0		 5cswB-1d5cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		3 / 3 LYS A 142
GLN A  97
ASN A 101
 None
 0.86A 5l2tA-1d5cA:
undetectable		 5l2tA-1d5cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		4 / 6 ILE A 161
ILE A 118
LEU A  14
PHE A  16
 None
 1.04A 5vkqB-1d5cA:
0.0
5vkqC-1d5cA:
undetectable		 5vkqB-1d5cA:
7.05
5vkqC-1d5cA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1d5c RAB6 GTPASE
(Plasmodium
falciparum) 		4 / 6 ILE A 161
ILE A 118
LEU A  14
PHE A  16
 None
 1.03A 5vkqC-1d5cA:
undetectable
5vkqD-1d5cA:
0.0		 5vkqC-1d5cA:
7.05
5vkqD-1d5cA:
7.05