SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 VAL A 717
LEU A 500
GLY A 597
SER A 548
PHE A 552
 None
 1.42A 1fdsA-1d5fA:
undetectable		 1fdsA-1d5fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 PHE A 578
VAL A 614
LEU A 618
PHE A 567
 None
 1.01A 1wrlB-1d5fA:
undetectable		 1wrlB-1d5fA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.01A 1z9hA-1d5fA:
0.0		 1z9hA-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.01A 1z9hB-1d5fA:
0.0		 1z9hB-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.00A 1z9hC-1d5fA:
0.0		 1z9hC-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PRO A 580
SER A 695
TYR A 694
ILE A 698
LEU A 639
 None
 1.00A 1z9hD-1d5fA:
0.0		 1z9hD-1d5fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PHE A 610
ILE A 559
PHE A 560
GLY A 713
LEU A 618
 None
 1.28A 2lbdA-1d5fA:
0.0		 2lbdA-1d5fA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 8 MET A 802
LEU A 835
ILE A 770
LEU A 839
LEU A 826
 None
 1.41A 2xfhA-1d5fA:
0.0		 2xfhA-1d5fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 ASP A 507
ALA A 513
VAL A 547
LEU A 554
VAL A 555
 None
 0.94A 2yqzB-1d5fA:
undetectable		 2yqzB-1d5fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 PHE A 589
GLY A 713
GLY A 597
LEU A 596
VAL A 595
 None
 1.07A 3av6A-1d5fA:
undetectable		 3av6A-1d5fA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 12 ILE A 770
LEU A 840
ALA A 842
ILE A 843
ILE A 804
 None
 1.03A 3b2rA-1d5fA:
undetectable		 3b2rA-1d5fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 11 ILE A 770
LEU A 840
ALA A 842
ILE A 843
ILE A 804
 None
 1.07A 3b2rB-1d5fA:
undetectable		 3b2rB-1d5fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		5 / 11 ILE A 770
LEU A 840
ALA A 842
ILE A 843
PHE A 774
 None
 1.14A 3b2rB-1d5fA:
undetectable		 3b2rB-1d5fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		3 / 3 ARG A 791
ASP A 607
ASP A 790
 None
 0.91A 3jb2A-1d5fA:
0.1		 3jb2A-1d5fA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		3 / 3 ARG A 791
ASP A 607
ASP A 790
 None
 0.89A 3jb3A-1d5fA:
0.1		 3jb3A-1d5fA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		3 / 3 LYS A 497
TYR A 499
ARG A 501
 None
 0.81A 4gc9A-1d5fA:
undetectable		 4gc9A-1d5fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 5 LYS A 806
LEU A 826
GLU A 828
LEU A 763
 None
 1.22A 4k4yA-1d5fA:
0.0		 4k4yA-1d5fA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 4 LYS A 806
LEU A 826
GLU A 828
LEU A 763
 None
 1.25A 4k4yE-1d5fA:
0.0		 4k4yE-1d5fA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 5 LYS A 806
LEU A 826
GLU A 828
LEU A 763
 None
 1.24A 4k4yI-1d5fA:
0.0		 4k4yI-1d5fA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 8 LEU A 642
LEU A 639
LEU A 635
ILE A 682
 None
 0.74A 4klaA-1d5fA:
undetectable		 4klaA-1d5fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 5 GLU A 558
VAL A 555
VAL A 504
PHE A 551
 None
 0.92A 4lb0B-1d5fA:
0.0		 4lb0B-1d5fA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 ARG A 616
ARG A 626
VAL A 613
ASP A 627
 None
 1.38A 4xqeA-1d5fA:
undetectable		 4xqeA-1d5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 ARG A 616
ARG A 626
VAL A 613
ASP A 627
 None
 1.37A 4xqeB-1d5fA:
undetectable		 4xqeB-1d5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 PHE A 625
SER A 631
HIS A 632
LEU A 699
 None
 1.27A 5dzke-1d5fA:
undetectable
5dzks-1d5fA:
undetectable		 5dzke-1d5fA:
23.18
5dzks-1d5fA:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 PHE A 625
SER A 631
HIS A 632
LEU A 699
 None
 1.27A 5dzkg-1d5fA:
undetectable
5dzku-1d5fA:
undetectable		 5dzkg-1d5fA:
23.18
5dzku-1d5fA:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 6 ILE A 843
PHE A 767
THR A 751
TRP A 768
 None
 1.23A 5g08A-1d5fA:
0.0		 5g08A-1d5fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		3 / 3 LYS A 841
LEU A 826
ILE A 770
 None
 0.68A 5kc0A-1d5fA:
1.3		 5kc0A-1d5fA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		3 / 3 LYS A 841
LEU A 826
ILE A 770
 None
 0.82A 5kc4A-1d5fA:
1.4		 5kc4A-1d5fA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens) 		4 / 8 ARG A 780
THR A 789
ILE A 605
PRO A 793
 None
 1.09A 6a4iA-1d5fA:
0.4		 6a4iA-1d5fA:
19.90