SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 8 GLY A  13
GLY A  41
TYR A 404
VAL A 287
 None
 0.78A 1dbbH-1d5tA:
undetectable
1dbbL-1d5tA:
undetectable		 1dbbH-1d5tA:
19.77
1dbbL-1d5tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 8 VAL A 343
ASN A  73
GLY A  40
LEU A  14
 None
 0.86A 1dzmA-1d5tA:
0.0		 1dzmA-1d5tA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 7 GLU A  95
LEU A  92
VAL A  88
LEU A 234
 None
 0.94A 1hk3A-1d5tA:
undetectable		 1hk3A-1d5tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 TYR A 192
VAL A 147
PHE A 143
VAL A 171
THR A 166
 SO4  A 502 (-4.9A)
None
None
None
None
 1.22A 1q23B-1d5tA:
0.0		 1q23B-1d5tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 11 TYR A 192
VAL A 147
PHE A 143
VAL A 171
THR A 166
 SO4  A 502 (-4.9A)
None
None
None
None
 1.26A 1q23F-1d5tA:
0.0		 1q23F-1d5tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 8 PHE A 184
LEU A 189
ILE A 206
ILE A 209
 None
 0.92A 1sbrA-1d5tA:
undetectable		 1sbrA-1d5tA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 LEU A 231
TYR A 404
THR A  15
ILE A  18
PHE A 410
 None
 1.42A 1xoqA-1d5tA:
undetectable		 1xoqA-1d5tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 LEU A 231
TYR A 404
THR A  15
ILE A  18
PHE A 410
 None
 1.41A 1xoqB-1d5tA:
undetectable		 1xoqB-1d5tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 SER A 167
VAL A 171
THR A 157
ILE A 206
PHE A 146
 None
 1.45A 2vdyB-1d5tA:
0.0		 2vdyB-1d5tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 10 VAL A 147
TYR A 172
PHE A 143
PHE A 140
PHE A 184
 None
 1.50A 3r6wA-1d5tA:
2.6
3r6wB-1d5tA:
undetectable		 3r6wA-1d5tA:
19.86
3r6wB-1d5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 9 ALA A 344
ILE A 303
ILE A  46
ILE A 352
ILE A 350
 None
 1.04A 3s45A-1d5tA:
undetectable		 3s45A-1d5tA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 ASP A 391
ILE A 258
LEU A  10
GLY A 393
GLY A 263
 None
 0.85A 3vaqA-1d5tA:
3.4		 3vaqA-1d5tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 ASP A 391
ILE A 258
LEU A  10
GLY A 393
GLY A 263
 None
 0.88A 3vasB-1d5tA:
undetectable		 3vasB-1d5tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 5 ASP A 283
GLU A  42
GLY A  41
TYR A 286
 None
 1.23A 3w9tB-1d5tA:
0.0		 3w9tB-1d5tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 5 ASP A 283
GLU A  42
GLY A  41
TYR A 286
 None
 1.18A 3w9tD-1d5tA:
0.0		 3w9tD-1d5tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE503_1
(HEMOLYTIC LECTIN
CEL-III)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 4 ASP A 283
GLU A  42
GLY A  41
TYR A 286
 None
 1.18A 3w9tE-1d5tA:
0.0		 3w9tE-1d5tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 5 ASP A 283
GLU A  42
GLY A  41
TYR A 286
 None
 1.11A 3w9tE-1d5tA:
0.0		 3w9tE-1d5tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 5 ASP A 283
GLU A  42
GLY A  41
TYR A 286
 None
 1.16A 3w9tG-1d5tA:
0.0		 3w9tG-1d5tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 GLY A  13
HIS A  32
ASP A  34
ILE A  77
SER A 384
 None
 1.38A 4pooB-1d5tA:
undetectable		 4pooB-1d5tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		3 / 3 THR A 413
PRO A 389
ARG A 292
 None
 0.77A 5nd7B-1d5tA:
1.3		 5nd7B-1d5tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		5 / 12 ALA A 243
GLY A 247
LYS A  -2
GLU A 273
GLU A   3
 None
 1.23A 5nwuA-1d5tA:
undetectable		 5nwuA-1d5tA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 5 VAL A 265
LEU A  10
CYH A 282
ASP A 391
 None
 1.37A 5vcvA-1d5tA:
undetectable		 5vcvA-1d5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		3 / 3 THR A 356
THR A 355
ARG A 328
 None
 0.89A 5wm2A-1d5tA:
undetectable		 5wm2A-1d5tA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR
(Bos
taurus) 		4 / 4 PRO A 288
MET A 260
GLY A 267
VAL A 398
 None
 1.38A 6ak3A-1d5tA:
0.0		 6ak3A-1d5tA:
18.22