SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 MET A 248
GLY A 245
TYR A 244
LEU A 253
PHE A 239
 None
 1.21A 1brpA-1d5yA:
undetectable		 1brpA-1d5yA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 6 LEU A 283
THR A 199
TYR A 198
TYR A 244
 None
 1.38A 1qvuA-1d5yA:
0.0		 1qvuA-1d5yA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 10 VAL A  64
PHE A  96
GLN A  95
ARG A  57
ALA A  56
 None
 1.48A 2jj8A-1d5yA:
0.0		 2jj8A-1d5yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 VAL A  64
PHE A  96
GLN A  95
ARG A  57
ALA A  56
 None
 1.47A 2jj8C-1d5yA:
undetectable		 2jj8C-1d5yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 VAL A  64
PHE A  96
GLN A  95
ARG A  57
ALA A  56
 None
 1.43A 2vppA-1d5yA:
undetectable		 2vppA-1d5yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 VAL A  64
PHE A  96
GLN A  95
ARG A  57
ALA A  56
 None
 1.42A 2vppB-1d5yA:
undetectable		 2vppB-1d5yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		3 / 3 PRO A 100
LEU A  66
ARG A  71
 None
 0.85A 3aqiA-1d5yA:
undetectable		 3aqiA-1d5yA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		3 / 3 PRO A 100
LEU A  66
ARG A  71
 None
 0.85A 3aqiB-1d5yA:
0.0		 3aqiB-1d5yA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.38A 3elzA-1d5yA:
undetectable		 3elzA-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 11 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.37A 3elzB-1d5yA:
0.0		 3elzB-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 THR A 184
VAL A 196
LEU A 284
ILE A 285
TYR A 244
 None
 1.34A 3elzC-1d5yA:
0.0		 3elzC-1d5yA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 10 THR A 136
GLY A 221
GLU A 134
LEU A 219
ILE A 261
 None
 1.05A 3kvrA-1d5yA:
undetectable		 3kvrA-1d5yA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 10 THR A 136
GLY A 221
GLU A 134
LEU A 219
ILE A 261
 None
 1.04A 3kvrB-1d5yA:
undetectable		 3kvrB-1d5yA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 9 THR A 136
GLY A 221
GLU A 134
LEU A 219
ILE A 261
 None
 1.04A 3nbqA-1d5yA:
undetectable		 3nbqA-1d5yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 5 ILE A 261
ILE A 287
TYR A 224
GLU A 223
 None
 1.23A 4a99D-1d5yA:
undetectable		 4a99D-1d5yA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 8 SER A  62
LEU A  59
PHE A  82
PRO A 100
 None
 1.21A 4j7uD-1d5yA:
undetectable		 4j7uD-1d5yA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 11 LEU A 181
VAL A 217
ILE A 139
GLN A 206
PHE A 163
 None
 1.11A 5d75A-1d5yA:
undetectable		 5d75A-1d5yA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 7 GLY A 235
PHE A 239
SER A 153
ASN A 278
 None
 1.05A 5n5dB-1d5yA:
undetectable		 5n5dB-1d5yA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 7 TYR A 145
THR A  69
LEU A  68
THR A 184
 None
 0.77A 5ov9A-1d5yA:
undetectable		 5ov9A-1d5yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 8 TYR A 145
THR A  69
LEU A  68
THR A 184
 None
 0.69A 5ov9B-1d5yA:
undetectable		 5ov9B-1d5yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 11 LEU A  10
ASP A   9
ILE A  12
ILE A   7
LEU A  14
 None
 0.85A 5twjD-1d5yA:
undetectable		 5twjD-1d5yA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		5 / 12 GLY A 245
ALA A  63
GLU A 238
THR A 246
PHE A 123
 None
 1.08A 5x6yA-1d5yA:
0.0		 5x6yA-1d5yA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1d5y ROB TRANSCRIPTION
FACTOR
(Escherichia
coli) 		4 / 6 SER A  62
ASP A  19
GLU A 150
THR A  69
 None
 1.14A 6djzA-1d5yA:
0.0		 6djzA-1d5yA:
22.19