SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 6 GLU A  55
ILE A 136
TYR A 173
GLY A 172
 None
 0.99A 1maaB-1d6nA:
undetectable
1maaD-1d6nA:
undetectable		 1maaB-1d6nA:
17.45
1maaD-1d6nA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 8 ALA A  68
ILE A 116
GLY A 117
GLY A 118
ILE A  99
 PRP  A 312 (-3.2A)
None
None
None
None
 1.22A 1sguA-1d6nA:
undetectable		 1sguA-1d6nA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 6 HIS A  38
ASP A 134
TYR A  71
HIS A 203
 None
PRP  A 312 ( 2.9A)
None
None
 1.50A 2einA-1d6nA:
undetectable
2einC-1d6nA:
undetectable		 2einA-1d6nA:
16.94
2einC-1d6nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 LEU A 124
LEU A 121
ILE A  61
LEU A 101
VAL A 115
 None
 1.16A 2po7A-1d6nA:
3.4		 2po7A-1d6nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 LEU A 124
LEU A 121
ILE A  61
LEU A 101
VAL A 115
 None
 1.16A 2po7B-1d6nA:
undetectable		 2po7B-1d6nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 10 ILE A  41
LEU A  40
VAL A   7
GLY A 179
THR A  45
 None
 1.14A 2wd9C-1d6nA:
4.4		 2wd9C-1d6nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 8 ALA A 191
PHE A  98
PHE A  74
ALA A  75
 None
 1.00A 3t3sE-1d6nA:
0.0		 3t3sE-1d6nA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 7 TYR A 194
ILE A 207
GLY A 189
PHE A 198
 None
 0.82A 4iqqA-1d6nA:
0.0		 4iqqA-1d6nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 8 TYR A 194
ILE A 207
GLY A 189
PHE A 198
 None
 0.87A 4iqqD-1d6nA:
0.0		 4iqqD-1d6nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jksA-1d6nA:
undetectable		 4jksA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jksB-1d6nA:
undetectable		 4jksB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jkuA-1d6nA:
undetectable		 4jkuA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4k8cA-1d6nA:
undetectable		 4k8cA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4k8cB-1d6nA:
undetectable		 4k8cB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4k8kA-1d6nA:
undetectable		 4k8kA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.01A 4k8kB-1d6nA:
undetectable		 4k8kB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4kahA-1d6nA:
undetectable		 4kahA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kahB-1d6nA:
undetectable		 4kahB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4kalA-1d6nA:
undetectable		 4kalA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kalB-1d6nA:
undetectable		 4kalB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.01A 4kanA-1d6nA:
undetectable		 4kanA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4kanB-1d6nA:
undetectable		 4kanB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kbeA-1d6nA:
undetectable		 4kbeA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4kbeB-1d6nA:
undetectable		 4kbeB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4lbgA-1d6nA:
undetectable		 4lbgA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4lbgB-1d6nA:
undetectable		 4lbgB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4lcaA-1d6nA:
undetectable		 4lcaA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4lcaB-1d6nA:
undetectable		 4lcaB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 4 ASP A 193
GLY A  70
ASP A 134
ASP A 137
 None
PRP  A 312 (-3.1A)
PRP  A 312 ( 2.9A)
PPO  A 300 ( 3.9A)
 1.13A 5e72A-1d6nA:
undetectable		 5e72A-1d6nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 7 TYR A 194
ILE A 207
GLY A 189
PHE A 198
 None
 0.83A 5nooA-1d6nA:
undetectable		 5nooA-1d6nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 8 TYR A 194
ILE A 207
GLY A 189
PHE A 198
 None
 0.86A 5nooD-1d6nA:
0.0		 5nooD-1d6nA:
21.97