SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 11 ILE A  44
GLY A 179
THR A 180
HIS A 152
GLY A 176
 None
PLP  A 501 (-3.9A)
PLP  A 501 (-3.6A)
None
PLP  A 501 (-3.5A)
 1.09A 1i7qA-1d6sA:
undetectable		 1i7qA-1d6sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 ILE A  44
GLY A 179
THR A 180
HIS A 152
GLY A 176
 None
PLP  A 501 (-3.9A)
PLP  A 501 (-3.6A)
None
PLP  A 501 (-3.5A)
 1.10A 1i7qC-1d6sA:
undetectable		 1i7qC-1d6sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 THR A 257
GLY A 274
ALA A 279
ALA A 280
ILE A 172
 None
 1.10A 1likA-1d6sA:
undetectable		 1likA-1d6sA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		6 / 9 LEU A 181
GLY A 178
VAL A 175
ALA A 201
LEU A 214
LEU A 240
 None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.1A)
None
None
None
 0.99A 1muoA-1d6sA:
undetectable		 1muoA-1d6sA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		3 / 3 THR A  72
LEU A  76
VAL A  79
 MET  A 401 (-3.8A)
None
None
 0.65A 1mz9E-1d6sA:
undetectable		 1mz9E-1d6sA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ALA A  75
GLY A  73
ILE A  44
ALA A  46
SER A  37
 None
 1.10A 1ve3A-1d6sA:
undetectable		 1ve3A-1d6sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 5 ASN A  69
THR A  72
GLN A 142
PHE A 143
 MET  A 401 ( 3.8A)
MET  A 401 (-3.8A)
MET  A 401 (-3.0A)
None
 1.38A 1xmuB-1d6sA:
undetectable		 1xmuB-1d6sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 LEU A 242
ILE A 243
VAL A 175
GLY A 174
LEU A 238
 None
None
PLP  A 501 ( 4.1A)
None
None
 1.21A 2bxeB-1d6sA:
undetectable		 2bxeB-1d6sA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 2dcfA-1d6sA:
undetectable		 2dcfA-1d6sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 6 LEU A  64
TYR A  85
ILE A  49
GLY A  56
 None
 0.90A 2du8A-1d6sA:
1.3		 2du8A-1d6sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 6 LEU A  64
TYR A  85
ILE A  49
GLY A  56
 None
 0.94A 2du8B-1d6sA:
1.5		 2du8B-1d6sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 8 GLY A 270
GLY A 274
THR A 257
ALA A 254
ALA A 275
 None
 1.38A 2ej3C-1d6sA:
undetectable		 2ej3C-1d6sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 11 ALA A  29
ILE A  22
ILE A 267
ALA A 269
VAL A 277
 None
 1.18A 2qhfA-1d6sA:
undetectable		 2qhfA-1d6sA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ILE A 249
ILE A 267
ILE A  22
THR A 257
LEU A 281
 None
 1.19A 2qo5A-1d6sA:
0.0		 2qo5A-1d6sA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 THR A 156
ILE A 160
GLY A 157
GLY A 183
THR A 180
 None
None
None
None
PLP  A 501 (-3.6A)
 1.16A 2y7wB-1d6sA:
undetectable		 2y7wB-1d6sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 11 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.08A 2zmaA-1d6sA:
0.0		 2zmaA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.12A 3a65A-1d6sA:
0.0		 3a65A-1d6sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 3a66A-1d6sA:
0.0		 3a66A-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 8 LEU A 306
ALA A 269
LEU A 268
MET A 262
 None
 0.82A 3cldB-1d6sA:
0.0		 3cldB-1d6sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 8 GLU A 150
ASN A 148
ASN A  47
MET A  48
 None
 1.31A 3kp6A-1d6sA:
0.0
3kp6B-1d6sA:
0.0		 3kp6A-1d6sA:
19.88
3kp6B-1d6sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 6 ASN A  47
MET A  48
GLU A 150
ASN A 148
 None
 1.38A 3kp6A-1d6sA:
0.0
3kp6B-1d6sA:
0.0		 3kp6A-1d6sA:
19.88
3kp6B-1d6sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 5 GLY A 118
LYS A 117
GLU A 114
GLY A 121
 None
 1.06A 3onnA-1d6sA:
undetectable		 3onnA-1d6sA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 THR A 113
PRO A  67
GLY A  70
GLY A 121
ALA A 122
 None
None
MET  A 401 (-4.2A)
None
None
 1.23A 3pp7B-1d6sA:
4.2		 3pp7B-1d6sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		3 / 3 GLY A 176
GLY A 178
THR A 180
 PLP  A 501 (-3.5A)
PLP  A 501 (-3.6A)
PLP  A 501 (-3.6A)
 0.23A 3si7B-1d6sA:
undetectable		 3si7B-1d6sA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 ILE A  44
SER A   8
ILE A 151
ALA A 147
GLU A 150
 None
 1.28A 3u6tA-1d6sA:
undetectable		 3u6tA-1d6sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ALA A 201
LEU A 181
LEU A 238
LEU A 240
ILE A 210
 None
 1.10A 3uvvA-1d6sA:
0.0		 3uvvA-1d6sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 10 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 3vwpA-1d6sA:
0.0		 3vwpA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 3vwqA-1d6sA:
0.0		 3vwqA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 11 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 3vwrA-1d6sA:
undetectable		 3vwrA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		6 / 9 VAL A 247
VAL A 246
VAL A 170
ILE A 172
GLY A 174
ALA A 275
 None
 1.11A 4fwdA-1d6sA:
0.0		 4fwdA-1d6sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 8 MET A  91
LEU A  87
THR A  68
LEU A  64
 None
None
MET  A 401 (-3.7A)
None
 0.87A 4iizB-1d6sA:
undetectable		 4iizB-1d6sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		3 / 3 GLY A 118
GLU A  93
THR A 113
 None
 0.58A 4kouA-1d6sA:
0.0		 4kouA-1d6sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 6 LEU A 181
GLY A 178
VAL A 175
ALA A 201
LEU A 240
 None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.1A)
None
None
 0.88A 4o0wA-1d6sA:
undetectable		 4o0wA-1d6sA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		4 / 4 GLU A 159
GLY A 157
HIS A 152
ARG A  43
 None
 1.15A 4r82A-1d6sA:
0.0
4r82B-1d6sA:
0.0		 4r82A-1d6sA:
19.63
4r82B-1d6sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 GLY A 174
GLY A 179
ASN A 237
SER A 173
ALA A 275
 None
PLP  A 501 (-3.9A)
None
None
None
 1.02A 4uciA-1d6sA:
undetectable		 4uciA-1d6sA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		3 / 3 LYS A 292
ILE A 294
ILE A 172
 None
 0.68A 4y0qA-1d6sA:
0.0		 4y0qA-1d6sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 ILE A  44
ALA A 147
ALA A  52
LEU A 140
ASN A 145
 None
 1.19A 4zo1X-1d6sA:
0.0		 4zo1X-1d6sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 LEU A  19
ILE A  27
GLY A  23
LEU A 261
VAL A 277
 None
 1.14A 5twjC-1d6sA:
undetectable		 5twjC-1d6sA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1d6s O-ACETYLSERINE
SULFHYDRYLASE
(Salmonella
enterica) 		5 / 12 LEU A 181
GLY A 178
VAL A 175
ALA A 201
ALA A 213
 None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.1A)
None
None
 0.73A 5xv7A-1d6sA:
undetectable		 5xv7A-1d6sA:
10.97