SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.79A 1ictD-1d6vL:
undetectable		 1ictD-1d6vL:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.85A 2aojA-1d6vL:
undetectable		 2aojA-1d6vL:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.80A 2aojB-1d6vL:
0.0		 2aojB-1d6vL:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		5 / 12 TYR L  86
LEU L 104
GLU L  79
LEU L  78
ARG L  61
 None
None
CD  L 501 (-2.4A)
None
CD  L 504 ( 4.3A)
 1.33A 2bxfB-1d6vL:
undetectable		 2bxfB-1d6vL:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU L 175
LEU L 136
PHE L 139
GLU L 143
 None
 0.94A 2vq5B-1d6vL:
undetectable		 2vq5B-1d6vL:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 ASP L 170
THR L 172
TYR L 140
THR L 109
 CD  L 502 ( 4.8A)
None
None
None
 1.30A 5b6iA-1d6vL:
undetectable		 5b6iA-1d6vL:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 6 ASP L 170
THR L 172
TYR L 140
THR L 109
 CD  L 502 ( 4.8A)
None
None
None
 1.28A 5b6iB-1d6vL:
0.8		 5b6iB-1d6vL:
21.95