SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		5 / 10 ASP A  68
GLY A  62
GLY A  58
PRO A  93
ALA A  87
 None
None
HEM  A 401 (-3.5A)
HEM  A 401 (-4.5A)
None
 0.99A 1sh9B-1d7bA:
undetectable		 1sh9B-1d7bA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 5 ASP A  68
GLY A  58
PRO A  93
ALA A  87
 None
HEM  A 401 (-3.5A)
HEM  A 401 (-4.5A)
None
 0.82A 2aofA-1d7bA:
undetectable		 2aofA-1d7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 5 ASP A  68
GLY A  58
PRO A  93
ALA A  87
 None
HEM  A 401 (-3.5A)
HEM  A 401 (-4.5A)
None
 0.68A 2aohA-1d7bA:
undetectable		 2aohA-1d7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 8 GLY A  62
GLY A  63
ALA A  60
PHE A 169
 None
None
HEM  A 401 ( 4.2A)
None
 0.49A 2ha4A-1d7bA:
undetectable		 2ha4A-1d7bA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 4 PRO A  93
THR A  94
GLY A  98
THR A  99
 HEM  A 401 (-4.5A)
None
None
None
 1.14A 3ib1A-1d7bA:
undetectable		 3ib1A-1d7bA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 5 PHE A 166
ILE A  57
MET A  65
PHE A 145
 HEM  A 401 (-3.8A)
None
HEM  A 401 (-2.3A)
None
 1.29A 3octA-1d7bA:
0.0		 3octA-1d7bA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		5 / 10 ASN A  67
GLY A  89
TYR A  90
GLY A  62
ALA A  64
 None
None
HEM  A 401 (-4.0A)
None
HEM  A 401 (-3.8A)
 1.26A 3pp7B-1d7bA:
undetectable		 3pp7B-1d7bA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		3 / 3 TRP A 127
GLN A 122
THR A 125
 None
 0.99A 4m2xA-1d7bA:
0.0		 4m2xA-1d7bA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		3 / 3 THR A 164
SER A 146
ASP A 151
 None
 0.84A 5kvaA-1d7bA:
undetectable		 5kvaA-1d7bA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		4 / 5 THR A 175
HIS A 177
ALA A 176
ASP A 172
 None
 1.39A 5mfxA-1d7bA:
0.0		 5mfxA-1d7bA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		5 / 12 PRO A  93
VAL A 150
PHE A 119
GLN A 157
PHE A 160
 HEM  A 401 (-4.5A)
None
None
None
HEM  A 401 (-4.8A)
 1.43A 6becA-1d7bA:
0.0
6becB-1d7bA:
0.2
6becC-1d7bA:
0.0		 6becA-1d7bA:
16.15
6becB-1d7bA:
16.15
6becC-1d7bA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1d7b CELLOBIOSE
DEHYDROGENASE
(Phanerochaete
chrysosporium) 		5 / 10 GLY A 132
GLY A 131
ASN A 129
ILE A 133
GLY A  62
 None
 1.02A 6e5zA-1d7bA:
undetectable		 6e5zA-1d7bA:
19.62