SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 11 LEU C 464
GLY C 479
GLY C 480
VAL C 491
LEU C 495
LEU C 460
 None
 1.44A 1mx1A-1d7wC:
undetectable		 1mx1A-1d7wC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 12 LEU C 464
GLY C 479
GLY C 480
VAL C 491
LEU C 495
LEU C 460
 None
 1.43A 1mx1D-1d7wC:
undetectable		 1mx1D-1d7wC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 TYR C 334
LEU A  97
LEU A  93
ALA C 496
PHE C 503
 HEM  A 605 ( 4.8A)
None
None
None
None
 1.23A 1tbfA-1d7wC:
0.0		 1tbfA-1d7wC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ASP C 142
GLU C 408
ARG C 403
 None
 0.85A 1wopA-1d7wC:
0.0		 1wopA-1d7wC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 ILE C 537
ILE C 290
ILE C 551
LEU C 260
 None
 0.85A 1zgyA-1d7wC:
0.0		 1zgyA-1d7wC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 GLY C 302
ALA C 496
ALA C 305
TYR C 309
ARG C 307
 None
None
None
None
ACT  C1607 (-3.5A)
 1.30A 2avdA-1d7wC:
undetectable		 2avdA-1d7wC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 8 LEU C 464
TYR C 468
ILE A  68
ILE C 397
 None
 0.75A 2bu8A-1d7wC:
undetectable		 2bu8A-1d7wC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		5 / 9 LEU C 415
LEU C 406
LEU C 128
ARG A  62
ILE C 144
 None
 1.27A 2f78A-1d7wC:
undetectable		 2f78A-1d7wC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 LEU C 211
VAL C 359
MET C 343
ILE C 380
 None
 1.10A 2hyyC-1d7wC:
undetectable		 2hyyC-1d7wC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ARG C 239
ILE C 402
HIS C 336
GLY A  90
LEU C 495
 HEM  A 605 (-4.3A)
None
HEM  A 605 (-3.3A)
HEM  A 605 (-3.5A)
None
 1.35A 2nyrB-1d7wC:
undetectable		 2nyrB-1d7wC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 LEU C 210
LEU C 381
PHE C 233
 None
 0.73A 2pgrA-1d7wC:
undetectable		 2pgrA-1d7wC:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 HIS A  95
ARG C 239
GLU C 242
PHE C 366
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.66A 2qqtA-1d7wA:
3.3		 2qqtA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 HIS A  95
ARG C 239
GLU C 242
PRO C 220
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 1.24A 2qqtA-1d7wA:
3.3		 2qqtA-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 LEU C 572
GLU C 263
ILE C 283
ILE A  10
 None
 0.64A 2xkwA-1d7wC:
0.0		 2xkwA-1d7wC:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 HIS A  95
ARG C 239
GLU C 242
PHE C 366
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.72A 3gclA-1d7wA:
undetectable		 3gclA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 HIS A  95
ARG C 239
GLU C 242
PRO C 220
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 1.18A 3gclA-1d7wA:
undetectable		 3gclA-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 VAL C 372
LEU C 254
LEU C 246
ILE C 230
 None
 0.96A 3gp0A-1d7wC:
undetectable		 3gp0A-1d7wC:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OGW_A_IMNA597_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		7 / 9 GLN A  91
HIS A  95
PHE A  99
GLU A 102
ARG C 239
GLU C 242
PHE C 366
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.9A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.73A 3ogwA-1d7wA:
3.7		 3ogwA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OGW_A_IMNA597_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		7 / 9 GLN A  91
HIS A  95
PHE A  99
GLU A 102
ARG C 239
GLU C 242
PHE C 407
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.9A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.44A 3ogwA-1d7wA:
3.7		 3ogwA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
PHE C 366
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.41A 3py4A-1d7wA:
2.6		 3py4A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
PHE C 407
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.31A 3py4A-1d7wA:
2.6		 3py4A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 HIS A  95
ARG C 239
GLU C 242
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
 0.43A 3qf1A-1d7wA:
undetectable		 3qf1A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 7 GLN A  91
HIS A  95
ARG C 239
GLU C 242
PHE C 366
PRO C 220
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
None
 1.34A 3ql6A-1d7wA:
undetectable		 3ql6A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 7 GLN A  91
HIS A  95
GLU A 102
ARG C 239
GLU C 242
PHE C 366
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.69A 3ql6A-1d7wA:
undetectable		 3ql6A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 7 GLN A  91
HIS A  95
GLU A 102
ARG C 239
GLU C 242
PHE C 407
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.38A 3ql6A-1d7wA:
undetectable		 3ql6A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		5 / 5 GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
 HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
 0.36A 3r4xA-1d7wA:
undetectable		 3r4xA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 ARG C 239
GLU C 242
PHE C 366
PRO C 220
 HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
None
 1.38A 3r4xA-1d7wC:
34.6		 3r4xA-1d7wC:
45.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		5 / 5 GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
 HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
 0.33A 3r55A-1d7wA:
undetectable		 3r55A-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 8 ALA C 209
ASP C 205
LEU C 252
THR C 251
 None
 0.79A 3roxA-1d7wC:
undetectable		 3roxA-1d7wC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 LYS C 282
SER C 521
GLN C 524
 None
 1.32A 3si7A-1d7wC:
undetectable		 3si7A-1d7wC:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TGY_A_ASCA800_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		4 / 4 HIS A  95
ARG C 239
GLU C 242
PHE C 366
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 3tgyA-1d7wA:
undetectable		 3tgyA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TGY_A_ASCA800_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		4 / 4 HIS A  95
ARG C 239
GLU C 242
PHE C 407
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.10A 3tgyA-1d7wA:
undetectable		 3tgyA-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 5 LEU C 310
ARG C 507
ILE C 290
ARG C 294
 None
 0.99A 3ticA-1d7wC:
undetectable		 3ticA-1d7wC:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 10 ARG C 426
GLY C 432
MET C 478
GLY C 480
THR C 329
 None
None
None
None
HEM  A 605 (-4.4A)
 1.50A 3x2qG-1d7wC:
0.0
3x2qN-1d7wC:
0.0
3x2qO-1d7wC:
0.0		 3x2qG-1d7wC:
11.19
3x2qN-1d7wC:
21.64
3x2qO-1d7wC:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 7 PHE C 503
VAL C 300
GLY A  90
PHE C 328
 None
None
HEM  A 605 (-3.5A)
None
 0.78A 4ejjB-1d7wC:
undetectable		 4ejjB-1d7wC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ARG C 403
TYR C 334
ASN C 330
 None
HEM  A 605 ( 4.8A)
None
 0.87A 4ffwB-1d7wC:
undetectable		 4ffwB-1d7wC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.65A 4fp9A-1d7wC:
undetectable		 4fp9A-1d7wC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.65A 4fp9C-1d7wC:
undetectable		 4fp9C-1d7wC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C 400
ARG C 403
ASP A  74
 SO4  A1602 (-4.7A)
None
None
 0.67A 4fp9F-1d7wC:
undetectable		 4fp9F-1d7wC:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GN6_A_TYLA621_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 HIS A  95
ARG C 239
GLU C 242
PHE C 366
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.45A 4gn6A-1d7wA:
undetectable		 4gn6A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GN6_A_TYLA621_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 HIS A  95
ARG C 239
GLU C 242
PHE C 407
 CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.10A 4gn6A-1d7wA:
undetectable		 4gn6A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.35A 4ig5A-1d7wA:
undetectable		 4ig5A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.34A 4ig5B-1d7wA:
undetectable		 4ig5B-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ARG C 239
GLU C 242
PHE C 366
 HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.36A 4kszA-1d7wC:
12.7		 4kszA-1d7wC:
45.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 ARG C 239
GLU C 242
PHE C 407
 HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 0.95A 4kszA-1d7wC:
12.7		 4kszA-1d7wC:
45.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 9 TYR C 468
VAL A  69
ILE C 397
LEU C 451
LEU C 455
 None
 1.34A 4l1xB-1d7wC:
0.0		 4l1xB-1d7wC:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 GLY C 195
GLY C 273
ALA C 280
LEU C 276
HIS C 257
 None
 1.08A 4l8fD-1d7wC:
undetectable		 4l8fD-1d7wC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 HIS C 428
TRP C 436
SER C 149
 None
None
CSO  C 150 ( 4.4A)
 0.91A 4lrhD-1d7wC:
0.0		 4lrhD-1d7wC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		4 / 5 SER C 425
GLU A  36
ASP C 475
ASN C 472
 None
 1.34A 4pclA-1d7wC:
undetectable		 4pclA-1d7wC:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 GLN A  91
HIS A  95
ARG C 239
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
 0.37A 4qyqA-1d7wA:
undetectable		 4qyqA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 GLN A  91
HIS A  95
ARG C 239
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
 0.31A 4qyqB-1d7wA:
undetectable		 4qyqB-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 6 GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
ARG C 333
 HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
 0.40A 4qyqC-1d7wA:
3.3		 4qyqC-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_D_3CJD607_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 GLN A  91
HIS A  95
ARG C 239
GLU C 242
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
 0.34A 4qyqD-1d7wA:
undetectable		 4qyqD-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ILE C 413
ASP C 142
ALA A  63
ALA A  61
ASN A  66
 None
 1.25A 4u14A-1d7wC:
undetectable		 4u14A-1d7wC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1d7w MYELOPEROXIDASE
MYELOPEROXIDASE
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLY C 432
SER C 425
GLU A  36
ASP C 475
 None
 1.25A 4xueA-1d7wC:
undetectable		 4xueA-1d7wC:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 TYR C 468
VAL A  69
ILE C 397
LEU C 451
LEU C 455
 None
 1.20A 4yvpB-1d7wC:
undetectable		 4yvpB-1d7wC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 6 SER C 368
PRO C 244
PHE C 366
GLU C 242
 None
None
None
HEM  A 605 (-2.1A)
 1.27A 5b8iA-1d7wC:
undetectable		 5b8iA-1d7wC:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 5ff1A-1d7wA:
undetectable		 5ff1A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 5ff1A-1d7wA:
undetectable		 5ff1A-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 5ff1B-1d7wA:
3.2		 5ff1B-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
LEU C 246
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.31A 5ff1B-1d7wA:
3.2		 5ff1B-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 5 GLN A  91
HIS A  95
ARG C 239
GLU C 242
ARG C 333
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
 0.47A 5hpwA-1d7wA:
undetectable		 5hpwA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_B_3CJB609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 GLN A  91
HIS A  95
ARG C 239
ARG C 333
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.9A)
 0.32A 5hpwB-1d7wA:
0.0		 5hpwB-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		6 / 6 GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
ARG C 333
 HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
 0.40A 5hpwC-1d7wA:
3.3		 5hpwC-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_D_3CJD609_1
(LACTOPEROXIDASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 4 GLN A  91
HIS A  95
ARG C 239
GLU C 242
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
 0.34A 5hpwD-1d7wA:
undetectable		 5hpwD-1d7wA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 11 GLY C 376
VAL C 371
GLU C 374
ASP C 378
ILE C 377
 None
 1.22A 5i3cC-1d7wC:
undetectable		 5i3cC-1d7wC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 PHE C 520
LEU C 260
ILE C 536
ALA C 173
LEU C 253
 None
None
ACT  C1609 (-4.5A)
None
None
 1.36A 5ienA-1d7wC:
0.0		 5ienA-1d7wC:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
THR A  11
ARG C 281
SER C 174
GLY C 178
 CA  C1600 (-3.5A)
None
None
CA  C1600 (-2.5A)
None
 1.28A 5l5zV-1d7wC:
undetectable
5l5zb-1d7wC:
undetectable		 5l5zV-1d7wC:
19.18
5l5zb-1d7wC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
THR A  11
ARG C 281
SER C 174
GLY C 178
 CA  C1600 (-3.5A)
None
None
CA  C1600 (-2.5A)
None
 1.28A 5l5zH-1d7wC:
undetectable
5l5zN-1d7wC:
undetectable		 5l5zH-1d7wC:
19.18
5l5zN-1d7wC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
ARG C 281
SER C 174
GLY C 178
ALA C 184
 CA  C1600 (-3.5A)
None
CA  C1600 (-2.5A)
None
None
 1.39A 5lf3b-1d7wC:
undetectable		 5lf3b-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
THR A  11
ARG C 281
SER C 174
GLY C 178
 CA  C1600 (-3.5A)
None
None
CA  C1600 (-2.5A)
None
 1.26A 5lf3b-1d7wC:
undetectable		 5lf3b-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
ARG C 281
SER C 174
GLY C 178
ALA C 184
 CA  C1600 (-3.5A)
None
CA  C1600 (-2.5A)
None
None
 1.39A 5lf3N-1d7wC:
undetectable		 5lf3N-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 THR C 168
THR A  11
ARG C 281
SER C 174
GLY C 178
 CA  C1600 (-3.5A)
None
None
CA  C1600 (-2.5A)
None
 1.26A 5lf3N-1d7wC:
undetectable		 5lf3N-1d7wC:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		3 / 3 PHE C 203
ASP C 205
LEU C 197
 None
 0.71A 5uhcC-1d7wC:
0.0		 5uhcC-1d7wC:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		4 / 9 TYR C 296
ILE C 291
ILE C 531
LEU C 528
 None
None
ACT  C1609 (-3.8A)
None
 0.78A 5vkqB-1d7wC:
0.0
5vkqC-1d7wC:
0.0		 5vkqB-1d7wC:
14.08
5vkqC-1d7wC:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 10 MET C 478
GLY C 480
THR C 329
ARG C 426
GLY C 432
 None
None
HEM  A 605 (-4.4A)
None
None
 1.47A 5wauA-1d7wC:
0.3
5wauB-1d7wC:
0.0
5waug-1d7wC:
0.0		 5wauA-1d7wC:
21.64
5wauB-1d7wC:
18.12
5waug-1d7wC:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1d7w MYELOPEROXIDASE
(Homo
sapiens) 		5 / 12 ARG C 161
ASP C 475
ASN C 330
TYR C 468
ALA A  59
 ACT  C1606 (-2.9A)
None
None
None
None
 1.17A 5x66A-1d7wC:
0.0
5x66B-1d7wC:
undetectable		 5x66A-1d7wC:
20.74
5x66B-1d7wC:
20.74