SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 1c9sD-1d8cA:
0.0
1c9sE-1d8cA:
0.0		 1c9sD-1d8cA:
8.26
1c9sE-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 1c9sG-1d8cA:
0.0
1c9sH-1d8cA:
0.0		 1c9sG-1d8cA:
8.26
1c9sH-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 1c9sH-1d8cA:
0.0
1c9sI-1d8cA:
0.0		 1c9sH-1d8cA:
8.26
1c9sI-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.44A 1c9sJ-1d8cA:
0.0
1c9sK-1d8cA:
0.0		 1c9sJ-1d8cA:
8.26
1c9sK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 5 THR A 578
GLU A 460
THR A 457
LEU A 471
 None
 1.38A 1d4fC-1d8cA:
undetectable		 1d4fC-1d8cA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 GLN A  61
HIS A 462
PRO A 704
 None
SOR  A4000 (-3.8A)
SOR  A4000 (-3.1A)
 0.00A 1d8cA-1d8cA:
67.1		 1d8cA-1d8cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 GLU A 398
LEU A  53
LEU A  54
LEU A  46
 None
 0.97A 1ereE-1d8cA:
undetectable		 1ereE-1d8cA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 GLU A 398
LEU A  53
LEU A  54
LEU A  46
 None
 0.96A 1ereF-1d8cA:
undetectable		 1ereF-1d8cA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 LEU A 372
VAL A 386
LEU A 420
ALA A 416
 None
 0.83A 1fiqC-1d8cA:
0.0		 1fiqC-1d8cA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 1gtfP-1d8cA:
0.0
1gtfQ-1d8cA:
0.0		 1gtfP-1d8cA:
8.26
1gtfQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 VAL A 261
VAL A 259
ILE A 167
LEU A 174
 None
 0.76A 1igxA-1d8cA:
0.7		 1igxA-1d8cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 7 ASP A 273
GLU A 428
GLU A 427
GLU A 398
 MG  A3001 ( 4.9A)
None
MG  A3001 ( 2.6A)
None
 1.21A 1knyA-1d8cA:
0.0
1knyB-1d8cA:
0.0		 1knyA-1d8cA:
16.76
1knyB-1d8cA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 GLU A 595
TRP A 645
LYS A 506
 None
 0.96A 1qu2A-1d8cA:
0.0		 1qu2A-1d8cA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 1utdC-1d8cA:
0.0
1utdD-1d8cA:
0.0		 1utdC-1d8cA:
8.26
1utdD-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.44A 1utdN-1d8cA:
0.0
1utdO-1d8cA:
undetectable		 1utdN-1d8cA:
8.26
1utdO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 5 SER A 463
LEU A  91
LEU A  88
LEU A 433
 None
 1.13A 1yajD-1d8cA:
2.4		 1yajD-1d8cA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ASP A 374
ILE A 105
VAL A 389
 None
 0.71A 2avvD-1d8cA:
undetectable		 2avvD-1d8cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 TRP A 481
LYS A  78
PRO A 480
 None
 1.42A 2dqyB-1d8cA:
1.3		 2dqyB-1d8cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.31A 2e7fA-1d8cA:
8.0		 2e7fA-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 ILE A 642
LEU A 596
GLY A 602
GLN A 670
ILE A 603
 None
 1.22A 2e7fB-1d8cA:
8.5		 2e7fB-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.33A 2e7fB-1d8cA:
8.5		 2e7fB-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 ALA A 442
PHE A 406
THR A 407
LYS A 421
 None
 1.15A 2kotB-1d8cA:
0.0		 2kotB-1d8cA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 ILE A 642
LEU A 596
GLY A 602
GLN A 670
ILE A 603
 None
 1.35A 2ogyA-1d8cA:
7.9		 2ogyA-1d8cA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.32A 2ogyA-1d8cA:
7.9		 2ogyA-1d8cA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.32A 2ogyB-1d8cA:
8.3		 2ogyB-1d8cA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 PHE A  16
ASP A 363
ASN A 339
ILE A 388
GLY A 368
 None
 1.25A 2ogyB-1d8cA:
8.3		 2ogyB-1d8cA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 LEU A 178
ASN A 233
LEU A 236
GLY A 235
GLN A 112
 None
 1.46A 2yhdA-1d8cA:
undetectable		 2yhdA-1d8cA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 ILE A 449
ILE A 424
VAL A 399
GLY A 395
VAL A  98
 None
 1.19A 3elzC-1d8cA:
0.0		 3elzC-1d8cA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 ILE A 449
ILE A 424
VAL A 399
GLY A 395
VAL A  98
 None
 1.23A 3em0A-1d8cA:
1.4		 3em0A-1d8cA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 338
GLU A 359
ASP A 279
 GLV  A2000 (-3.6A)
None
None
 0.87A 3g2oA-1d8cA:
0.2		 3g2oA-1d8cA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 HIS A 342
LEU A  53
GLY A 395
LEU A 435
ALA A 402
 None
 1.04A 3i5uA-1d8cA:
undetectable		 3i5uA-1d8cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 HIS A 342
LEU A  53
GLY A 395
LEU A 435
ALA A 402
 None
 1.05A 3i5uB-1d8cA:
2.9		 3i5uB-1d8cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 5 ASP A 455
ASP A 273
PRO A 391
GLU A 427
 MG  A3001 ( 3.0A)
MG  A3001 ( 4.9A)
None
MG  A3001 ( 2.6A)
 1.46A 3l2uA-1d8cA:
0.0		 3l2uA-1d8cA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 5 ASP A 455
ASP A 273
PRO A 391
GLU A 427
 MG  A3001 ( 3.0A)
MG  A3001 ( 4.9A)
None
MG  A3001 ( 2.6A)
 1.45A 3l2wA-1d8cA:
0.0		 3l2wA-1d8cA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 ILE A 147
ILE A 148
GLN A 165
ALA A 168
ALA A 516
 None
 0.96A 3ozvB-1d8cA:
undetectable		 3ozvB-1d8cA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 11 ALA A 121
LEU A 286
LEU A 285
GLY A 292
LEU A 293
 None
 1.25A 3uudA-1d8cA:
0.0		 3uudA-1d8cA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 LEU A 362
THR A   4
ILE A 361
ALA A  47
ASP A 351
 None
 1.15A 3vw1D-1d8cA:
2.0		 3vw1D-1d8cA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 636
LYS A 392
ARG A 632
 None
MG  A3001 ( 4.0A)
None
 1.15A 3w1wA-1d8cA:
0.4
3w1wB-1d8cA:
0.4		 3w1wA-1d8cA:
19.86
3w1wB-1d8cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 632
ARG A 636
LYS A 392
 None
None
MG  A3001 ( 4.0A)
 1.19A 3w1wA-1d8cA:
0.4
3w1wB-1d8cA:
0.4		 3w1wA-1d8cA:
19.86
3w1wB-1d8cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 ILE A 109
ASP A 106
ILE A 105
VAL A 100
 None
 0.79A 4ac9C-1d8cA:
2.5		 4ac9C-1d8cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 ILE A 109
ASP A 106
ILE A 105
VAL A 100
 None
 0.76A 4acaC-1d8cA:
2.3		 4acaC-1d8cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 7 GLY A 368
THR A 367
ILE A 370
PHE A  19
 None
 0.95A 4acaC-1d8cA:
2.5		 4acaC-1d8cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 ILE A 109
ASP A 106
ILE A 105
VAL A 100
 None
 0.76A 4acbC-1d8cA:
2.5		 4acbC-1d8cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 GLN A 525
ALA A 533
GLN A 116
ARG A 134
GLU A 262
 None
 1.27A 4azwA-1d8cA:
undetectable		 4azwA-1d8cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ASN A 418
LEU A 375
PHE A 406
 None
 0.76A 4dajB-1d8cA:
0.0		 4dajB-1d8cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 ILE A 260
GLU A 239
GLN A 241
ILE A 242
 SO4  A8000 (-3.9A)
SO4  A8000 ( 4.7A)
SO4  A8000 (-3.6A)
None
 0.79A 4mj8A-1d8cA:
undetectable		 4mj8A-1d8cA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 ILE A 242
ALA A 254
LEU A 240
LEU A 210
LEU A 198
 None
 1.19A 4qzuC-1d8cA:
0.0		 4qzuC-1d8cA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 VAL A 656
LEU A 660
VAL A 600
 None
 0.58A 4wq4A-1d8cA:
undetectable		 4wq4A-1d8cA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 11 ASP A 426
ALA A 447
VAL A 446
GLY A 505
GLY A 423
 None
 1.21A 4xnxA-1d8cA:
undetectable		 4xnxA-1d8cA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 7 TYR A 548
VAL A 553
ILE A 504
HIS A 544
 None
 1.18A 4xo7B-1d8cA:
6.2		 4xo7B-1d8cA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 5 GLU A 281
LYS A 720
ASP A 279
HIS A 713
 None
 1.25A 5a06A-1d8cA:
1.5		 5a06A-1d8cA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 11 ALA A 121
LEU A 286
LEU A 285
GLY A 292
LEU A 293
 None
 1.25A 5dxgB-1d8cA:
0.0		 5dxgB-1d8cA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeuB-1d8cA:
0.0
5eeuC-1d8cA:
0.0		 5eeuB-1d8cA:
8.26
5eeuC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeuE-1d8cA:
0.0
5eeuF-1d8cA:
0.0		 5eeuE-1d8cA:
8.26
5eeuF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.47A 5eeuG-1d8cA:
0.0
5eeuH-1d8cA:
0.0		 5eeuG-1d8cA:
8.26
5eeuH-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeuA-1d8cA:
0.0
5eeuK-1d8cA:
0.0		 5eeuA-1d8cA:
8.26
5eeuK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eeuN-1d8cA:
0.0
5eeuO-1d8cA:
0.0		 5eeuN-1d8cA:
8.26
5eeuO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eeuP-1d8cA:
0.0
5eeuQ-1d8cA:
undetectable		 5eeuP-1d8cA:
8.26
5eeuQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eevB-1d8cA:
0.0
5eevC-1d8cA:
0.0		 5eevB-1d8cA:
8.26
5eevC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eevE-1d8cA:
0.0
5eevF-1d8cA:
0.0		 5eevE-1d8cA:
8.26
5eevF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.47A 5eevG-1d8cA:
0.0
5eevH-1d8cA:
0.0		 5eevG-1d8cA:
8.26
5eevH-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eevA-1d8cA:
0.0
5eevK-1d8cA:
0.0		 5eevA-1d8cA:
8.26
5eevK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eevN-1d8cA:
0.0
5eevO-1d8cA:
undetectable		 5eevN-1d8cA:
8.26
5eevO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eevP-1d8cA:
0.0
5eevQ-1d8cA:
undetectable		 5eevP-1d8cA:
8.26
5eevQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eewB-1d8cA:
0.0
5eewC-1d8cA:
0.0		 5eewB-1d8cA:
8.26
5eewC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eewE-1d8cA:
0.0
5eewF-1d8cA:
0.0		 5eewE-1d8cA:
8.26
5eewF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eewA-1d8cA:
0.0
5eewK-1d8cA:
0.0		 5eewA-1d8cA:
8.26
5eewK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eewN-1d8cA:
undetectable
5eewO-1d8cA:
0.0		 5eewN-1d8cA:
8.26
5eewO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eewP-1d8cA:
0.0
5eewQ-1d8cA:
undetectable		 5eewP-1d8cA:
8.26
5eewQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eexB-1d8cA:
0.0
5eexC-1d8cA:
0.0		 5eexB-1d8cA:
8.26
5eexC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eexE-1d8cA:
0.0
5eexF-1d8cA:
0.0		 5eexE-1d8cA:
8.26
5eexF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eexA-1d8cA:
0.0
5eexK-1d8cA:
0.0		 5eexA-1d8cA:
8.26
5eexK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eexN-1d8cA:
0.0
5eexO-1d8cA:
undetectable		 5eexN-1d8cA:
8.26
5eexO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eexP-1d8cA:
undetectable
5eexQ-1d8cA:
undetectable		 5eexP-1d8cA:
8.26
5eexQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeyB-1d8cA:
0.0
5eeyC-1d8cA:
0.0		 5eeyB-1d8cA:
8.26
5eeyC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeyE-1d8cA:
0.0
5eeyF-1d8cA:
0.0		 5eeyE-1d8cA:
8.26
5eeyF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eeyA-1d8cA:
0.0
5eeyK-1d8cA:
0.0		 5eeyA-1d8cA:
8.26
5eeyK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eeyN-1d8cA:
0.0
5eeyO-1d8cA:
0.0		 5eeyN-1d8cA:
8.26
5eeyO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eeyP-1d8cA:
0.0
5eeyQ-1d8cA:
0.0		 5eeyP-1d8cA:
8.26
5eeyQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eezB-1d8cA:
0.0
5eezC-1d8cA:
0.0		 5eezB-1d8cA:
8.26
5eezC-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eezE-1d8cA:
0.0
5eezF-1d8cA:
0.0		 5eezE-1d8cA:
8.26
5eezF-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5eezA-1d8cA:
0.0
5eezK-1d8cA:
0.0		 5eezA-1d8cA:
8.26
5eezK-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5eezN-1d8cA:
undetectable
5eezO-1d8cA:
0.0		 5eezN-1d8cA:
8.26
5eezO-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5eezP-1d8cA:
0.0
5eezQ-1d8cA:
0.0		 5eezP-1d8cA:
8.26
5eezQ-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef0B-1d8cA:
0.0
5ef0C-1d8cA:
0.0		 5ef0B-1d8cA:
8.26
5ef0C-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef0E-1d8cA:
0.0
5ef0F-1d8cA:
0.0		 5ef0E-1d8cA:
8.26
5ef0F-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef0A-1d8cA:
0.0
5ef0K-1d8cA:
0.0		 5ef0A-1d8cA:
8.26
5ef0K-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5ef0N-1d8cA:
undetectable
5ef0O-1d8cA:
0.0		 5ef0N-1d8cA:
8.26
5ef0O-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5ef0P-1d8cA:
0.0
5ef0Q-1d8cA:
0.0		 5ef0P-1d8cA:
8.26
5ef0Q-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef1B-1d8cA:
0.0
5ef1C-1d8cA:
0.0		 5ef1B-1d8cA:
8.26
5ef1C-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef1E-1d8cA:
0.0
5ef1F-1d8cA:
0.0		 5ef1E-1d8cA:
8.26
5ef1F-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef1A-1d8cA:
0.0
5ef1K-1d8cA:
0.0		 5ef1A-1d8cA:
8.26
5ef1K-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5ef1N-1d8cA:
0.0
5ef1O-1d8cA:
undetectable		 5ef1N-1d8cA:
8.26
5ef1O-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5ef1P-1d8cA:
0.0
5ef1Q-1d8cA:
undetectable		 5ef1P-1d8cA:
8.26
5ef1Q-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef2B-1d8cA:
0.0
5ef2C-1d8cA:
0.0		 5ef2B-1d8cA:
8.26
5ef2C-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef2E-1d8cA:
0.0
5ef2F-1d8cA:
0.0		 5ef2E-1d8cA:
8.26
5ef2F-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef2A-1d8cA:
0.0
5ef2K-1d8cA:
0.0		 5ef2A-1d8cA:
8.26
5ef2K-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5ef2N-1d8cA:
0.0
5ef2O-1d8cA:
0.0		 5ef2N-1d8cA:
8.26
5ef2O-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5ef2P-1d8cA:
0.0
5ef2Q-1d8cA:
0.0		 5ef2P-1d8cA:
8.26
5ef2Q-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef3B-1d8cA:
0.0
5ef3C-1d8cA:
0.0		 5ef3B-1d8cA:
8.26
5ef3C-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 9 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.46A 5ef3E-1d8cA:
0.0
5ef3F-1d8cA:
0.0		 5ef3E-1d8cA:
8.26
5ef3F-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.48A 5ef3N-1d8cA:
0.0
5ef3O-1d8cA:
0.0		 5ef3N-1d8cA:
8.26
5ef3O-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 10 GLY A 360
HIS A 342
ALA A  47
THR A 345
ILE A 361
 None
 1.45A 5ef3P-1d8cA:
0.0
5ef3Q-1d8cA:
undetectable		 5ef3P-1d8cA:
8.26
5ef3Q-1d8cA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 436
ASN A 488
ASP A 574
 None
 0.92A 5gwxA-1d8cA:
undetectable		 5gwxA-1d8cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 6 PRO A 396
GLU A 568
LEU A 577
TYR A 485
 None
 0.87A 5igiA-1d8cA:
undetectable		 5igiA-1d8cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		5 / 12 ASP A  58
TYR A 707
GLU A 709
GLU A 427
GLU A 398
 SOR  A4000 ( 4.4A)
None
None
MG  A3001 ( 2.6A)
None
 1.47A 5iqeD-1d8cA:
0.0		 5iqeD-1d8cA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 LEU A 494
THR A 451
ASN A 450
 None
 0.71A 6baaE-1d8cA:
0.3		 6baaE-1d8cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 LEU A 494
THR A 451
ASN A 450
 None
 0.71A 6baaF-1d8cA:
0.4		 6baaF-1d8cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 LEU A 494
THR A 451
ASN A 450
 None
 0.71A 6baaG-1d8cA:
0.4		 6baaG-1d8cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 LEU A 494
THR A 451
ASN A 450
 None
 0.72A 6baaH-1d8cA:
0.3		 6baaH-1d8cA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 408
LYS A 404
ARG A  57
 None
 1.29A 6c06D-1d8cA:
0.0		 6c06D-1d8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 8 TRP A 610
HIS A 713
ARG A 636
GLU A 427
 None
None
None
MG  A3001 ( 2.6A)
 1.11A 6mn4C-1d8cA:
0.0		 6mn4C-1d8cA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		4 / 6 THR A 578
LEU A 577
THR A 479
LEU A 572
 None
 0.92A 6mvxA-1d8cA:
2.5
6mvxB-1d8cA:
2.3
6mvxC-1d8cA:
2.4		 6mvxA-1d8cA:
18.37
6mvxB-1d8cA:
18.37
6mvxC-1d8cA:
18.37