SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1d8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		6 / 12 THR A  49
ILE A  19
VAL A  21
TYR A  26
ILE A   2
VAL A  47
 None
 1.41A 1z9hD-1d8lA:
1.1		 1z9hD-1d8lA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		5 / 12 LEU A  71
LEU A 139
ASN A 100
ALA A 101
ALA A 109
 None
 1.16A 2bm9C-1d8lA:
undetectable		 2bm9C-1d8lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		5 / 11 LEU A  75
THR A  78
VAL A  81
LEU A 113
VAL A 111
 None
 1.18A 3tbgA-1d8lA:
undetectable		 3tbgA-1d8lA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		5 / 10 LEU A  75
THR A  78
VAL A  81
LEU A 113
VAL A 111
 None
 1.18A 3tbgC-1d8lA:
0.0		 3tbgC-1d8lA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		4 / 7 HIS A  29
LEU A  16
GLY A  62
PHE A  63
 None
 0.96A 3tehB-1d8lA:
2.5		 3tehB-1d8lA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Escherichia
coli) 		3 / 3 ASN A 100
LEU A  71
PHE A 140
 None
 0.81A 5dsgA-1d8lA:
0.0		 5dsgA-1d8lA:
18.10