SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1db3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 8 LEU A 211
LEU A 350
ALA A 353
LYS A 354
 None
 0.75A 1e7cA-1db3A:
undetectable		 1e7cA-1db3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 9 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.39A 1ncwH-1db3A:
undetectable
1ncwL-1db3A:
0.0		 1ncwH-1db3A:
19.95
1ncwL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 9 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.34A 1ru9H-1db3A:
0.0
1ru9L-1db3A:
0.0		 1ru9H-1db3A:
19.95
1ru9L-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 10 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.35A 1ruaH-1db3A:
0.0
1ruaL-1db3A:
0.0		 1ruaH-1db3A:
19.95
1ruaL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 8 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.37A 1rukH-1db3A:
undetectable
1rukL-1db3A:
undetectable		 1rukH-1db3A:
19.95
1rukL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 9 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.35A 1rulH-1db3A:
undetectable
1rulL-1db3A:
0.0		 1rulH-1db3A:
19.95
1rulL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 9 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.37A 1rumH-1db3A:
undetectable
1rumL-1db3A:
0.0		 1rumH-1db3A:
19.95
1rumL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 9 ALA A   4
TYR A  83
LEU A   5
GLY A  30
GLY A   8
 None
 1.39A 1rupH-1db3A:
undetectable
1rupL-1db3A:
undetectable		 1rupH-1db3A:
19.95
1rupL-1db3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 7 GLY A  86
SER A  89
ARG A  33
GLU A 134
 None
 1.03A 2c8aD-1db3A:
undetectable		 2c8aD-1db3A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 6 ILE A 304
ARG A 259
LEU A 273
LEU A 217
 None
 0.69A 2rlfA-1db3A:
0.0
2rlfD-1db3A:
0.0		 2rlfA-1db3A:
9.76
2rlfD-1db3A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 6 VAL A 168
GLN A 129
GLY A 108
LEU A  70
 None
 0.83A 3bjwE-1db3A:
undetectable		 3bjwE-1db3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 ILE A   6
GLY A   8
ILE A  31
ASP A  63
GLY A  30
 None
 1.06A 3bwcA-1db3A:
5.3		 3bwcA-1db3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 5 ASN A 169
ARG A 171
ASN A 180
ALA A 163
 None
 1.26A 3frqA-1db3A:
undetectable		 3frqA-1db3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 7 ASN A 169
ARG A 171
ASN A 180
ALA A 163
 None
 1.25A 3frqB-1db3A:
undetectable		 3frqB-1db3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 ASP A 105
ASN A  84
VAL A  82
ALA A 163
TYR A 162
 None
 1.23A 3ohtA-1db3A:
0.1
3ohtB-1db3A:
0.0		 3ohtA-1db3A:
21.30
3ohtB-1db3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 LEU A   5
TYR A  83
ALA A  18
GLY A  14
GLY A  30
 None
 1.12A 3ou7A-1db3A:
4.4		 3ou7A-1db3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 LEU A   5
TYR A  83
ALA A  18
GLY A  14
GLY A  30
 None
 1.13A 3ou7D-1db3A:
3.9		 3ou7D-1db3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		3 / 3 TYR A 151
GLU A 134
TYR A 156
 None
 0.96A 3ug8A-1db3A:
2.1		 3ug8A-1db3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		4 / 5 TYR A  83
GLU A  81
LEU A  21
GLN A 241
 None
 1.42A 4qztB-1db3A:
undetectable		 4qztB-1db3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		3 / 3 LEU A  74
VAL A   3
ASP A  80
 None
 0.71A 4y8wC-1db3A:
0.0		 4y8wC-1db3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 PHE A 275
LEU A 215
LEU A 217
PHE A 261
ALA A 265
 None
 1.37A 5ieoA-1db3A:
0.0		 5ieoA-1db3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A 346
ASP A 349
ALA A 266
ARG A 202
LEU A 215
 None
 1.17A 5syfB-1db3A:
7.3		 5syfB-1db3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 TYR A 156
SER A 154
ALA A 106
SER A  97
GLU A 134
 None
 1.28A 5wbvA-1db3A:
0.0		 5wbvA-1db3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 TYR A 156
SER A 154
ALA A 106
SER A  97
GLU A 134
 None
 1.29A 5wbvB-1db3A:
0.0		 5wbvB-1db3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 12 GLY A  14
ALA A 229
HIS A 228
VAL A  28
PHE A  57
 None
 1.21A 5x6yA-1db3A:
2.4		 5x6yA-1db3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		3 / 3 TYR A  16
ASP A  13
GLN A  12
 None
 0.94A 6g1pA-1db3A:
0.0		 6g1pA-1db3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1db3 GDP-MANNOSE
4,6-DEHYDRATASE
(Escherichia
coli) 		5 / 8 GLY A 227
HIS A 186
VAL A 233
GLY A 321
ALA A 326
 None
 1.28A 6hu9H-1db3A:
undetectable
6hu9e-1db3A:
undetectable		 6hu9H-1db3A:
13.59
6hu9e-1db3A:
16.98