SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 8 LEU A 324
ILE A 245
PHE A 246
PHE A 237
 None
 0.97A 2weyB-1dbhA:
undetectable		 2weyB-1dbhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 8 TYR A 353
LEU A 380
ALA A 299
ILE A 252
 None
 0.82A 3jusB-1dbhA:
0.3		 3jusB-1dbhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 4 PRO A 340
LEU A 339
ILE A 222
ARG A 227
 None
 1.40A 3w1wA-1dbhA:
undetectable		 3w1wA-1dbhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 6 GLU A 361
LYS A 370
LYS A 363
GLU A 365
 None
 1.43A 4a7tF-1dbhA:
0.0		 4a7tF-1dbhA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 5 ILE A 252
ILE A 212
TYR A 215
GLU A 211
 None
 1.03A 4a99D-1dbhA:
undetectable		 4a99D-1dbhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 8 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.17A 4j7uD-1dbhA:
undetectable		 4j7uD-1dbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		3 / 3 ASP A 241
ASN A 233
SER A 313
 None
 0.53A 4obwA-1dbhA:
undetectable		 4obwA-1dbhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		4 / 5 GLN A 336
LEU A 315
SER A 316
ASP A 309
 None
 1.09A 4qtuD-1dbhA:
undetectable		 4qtuD-1dbhA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		3 / 3 GLY A 438
CYH A 441
CYH A 440
 None
 0.93A 5inzB-1dbhA:
undetectable		 5inzB-1dbhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1dbh PROTEIN (HUMAN SOS
1)
(Homo
sapiens) 		5 / 12 MET A 538
LEU A 541
ILE A 461
HIS A 460
ALA A 528
 None
 1.20A 6djzA-1dbhA:
0.0		 6djzA-1dbhA:
20.11