SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 6 HIS A 216
PHE A 214
ASP A  30
PRO A  35
 None
 1.25A 1ilqA-1dbrA:
0.0
1ilqC-1dbrA:
undetectable		 1ilqA-1dbrA:
14.93
1ilqC-1dbrA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 8 VAL A 142
LEU A 162
SER A 131
VAL A 113
 None
 0.99A 1jtvA-1dbrA:
2.0		 1jtvA-1dbrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 LEU A 175
THR A 174
LEU A 143
LEU A  88
LEU A  87
 None
 1.08A 2ouzA-1dbrA:
0.0		 2ouzA-1dbrA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 4 ARG A  15
GLY A  14
GLU A  17
SER A 169
 None
 1.42A 2xctS-1dbrA:
0.0
2xctU-1dbrA:
2.8		 2xctS-1dbrA:
14.63
2xctU-1dbrA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 ILE A  77
PHE A 158
SER A 169
LEU A  72
ILE A  75
 None
 1.08A 2xkwB-1dbrA:
undetectable		 2xkwB-1dbrA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 8 VAL A 142
VAL A 165
ILE A  77
VAL A 113
 None
 0.88A 3hjoB-1dbrA:
undetectable		 3hjoB-1dbrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 PHE A 109
HIS A 111
VAL A 113
HIS A  73
LEU A 162
 None
 1.41A 3wfhA-1dbrA:
undetectable
3wfhB-1dbrA:
undetectable		 3wfhA-1dbrA:
18.58
3wfhB-1dbrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 PHE A 109
HIS A 111
VAL A 113
HIS A  73
LEU A 162
 None
 1.42A 3whxA-1dbrA:
undetectable
3whxB-1dbrA:
undetectable		 3whxA-1dbrA:
17.79
3whxB-1dbrA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 8 GLY A 152
GLU A 146
TYR A   9
LEU A 186
 None
MG  A 232 (-3.0A)
None
None
 0.91A 4fgzA-1dbrA:
2.2		 4fgzA-1dbrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 7 ILE A  42
ALA A 218
VAL A 217
ALA A 224
 None
 0.77A 4g77A-1dbrA:
undetectable		 4g77A-1dbrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		3 / 3 ARG A  15
LYS A  11
LYS A 187
 None
 0.99A 4k50E-1dbrA:
undetectable		 4k50E-1dbrA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 6 ILE A  75
GLY A  83
ASN A  86
ILE A  77
 None
 0.98A 5j4nB-1dbrA:
0.0		 5j4nB-1dbrA:
19.17