SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		3 / 3 ARG A 185
ARG A 196
ARG A 215
 U5P  A 250 (-2.6A)
None
U5P  A 250 (-3.8A)
 1.00A 1l7fA-1dbtA:
undetectable		 1l7fA-1dbtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		3 / 3 ARG A 185
ARG A 196
ARG A 215
 U5P  A 250 (-2.6A)
None
U5P  A 250 (-3.8A)
 0.99A 1l7hA-1dbtA:
undetectable		 1l7hA-1dbtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 8 THR A 179
VAL A 159
VAL A 144
ALA A 172
 None
 0.89A 2ij7C-1dbtA:
undetectable		 2ij7C-1dbtA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 6 GLY A 102
GLU A 105
GLY A 106
ASN A  71
 None
 0.79A 3e9rA-1dbtA:
undetectable		 3e9rA-1dbtA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 6 GLY A 102
GLU A 105
GLY A 106
ASN A  71
 None
 0.79A 3e9rC-1dbtA:
undetectable		 3e9rC-1dbtA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		5 / 9 LEU A 122
ALA A  89
VAL A 144
GLY A 158
ILE A 117
 U5P  A 250 (-4.2A)
None
None
None
None
 1.21A 3spkA-1dbtA:
undetectable		 3spkA-1dbtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 12 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.42A 4njuA-1dbtA:
undetectable		 4njuA-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 10 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.25A 4njuB-1dbtA:
undetectable		 4njuB-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 12 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.43A 4njuC-1dbtA:
undetectable		 4njuC-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		6 / 10 ASP A 189
VAL A 197
GLY A 214
ILE A 217
PRO A 200
THR A 199
 None
None
U5P  A 250 (-3.4A)
None
None
None
 1.26A 4njuD-1dbtA:
undetectable		 4njuD-1dbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Bacillus
subtilis) 		4 / 5 PRO A  67
THR A  69
ASN A  71
LYS A  72
 None
 1.06A 5x23A-1dbtA:
0.0		 5x23A-1dbtA:
20.42