SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 12 LEU A  72
LEU A  69
ASN A  68
LEU A  66
MET A  60
 None
 1.32A 1a28B-1dbwA:
undetectable		 1a28B-1dbwA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 12 ILE A 112
ILE A 111
MET A  22
ALA A  20
GLU A 116
 None
 1.32A 1ki7A-1dbwA:
1.4		 1ki7A-1dbwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 12 ILE A 112
ILE A 111
MET A  22
ALA A  20
GLU A 116
 None
 1.29A 1ki7B-1dbwA:
undetectable		 1ki7B-1dbwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 12 LEU A  72
LEU A  69
ASN A  68
LEU A  66
MET A  60
 None
 1.31A 1sqnA-1dbwA:
undetectable		 1sqnA-1dbwA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 5 ILE A 112
SER A  18
LEU A  23
ASN A  26
 None
 1.11A 1y0xX-1dbwA:
0.0		 1y0xX-1dbwA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 8 ALA A  98
LEU A  66
LEU A  65
ILE A  76
VAL A   9
 None
 1.47A 2uxpA-1dbwA:
0.0		 2uxpA-1dbwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 7 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.86A 4hyfA-1dbwA:
undetectable		 4hyfA-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 8 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.86A 4hyfB-1dbwA:
undetectable		 4hyfB-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 8 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.88A 4hyfC-1dbwA:
undetectable		 4hyfC-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		3 / 3 PHE A 106
ILE A  81
ASP A  86
 None
 0.77A 5cswA-1dbwA:
0.2		 5cswA-1dbwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		5 / 9 LEU A  19
ALA A  20
VAL A  52
HIS A   7
ILE A  81
 None
 1.19A 5om2A-1dbwA:
0.0
5om2B-1dbwA:
undetectable		 5om2A-1dbwA:
20.61
5om2B-1dbwA:
15.91