SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 114
SER A  76
ASN A  96
 None
 0.56A 1bx4A-1dc1A:
undetectable		 1bx4A-1dc1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  63
LEU A  98
SER A  94
LEU A  73
 None
None
DIO  A1008 (-3.3A)
None
 1.11A 1ya3A-1dc1A:
0.0		 1ya3A-1dc1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 142
ILE A 320
ILE A 280
ILE A 278
 None
 0.64A 2bu8A-1dc1A:
undetectable		 2bu8A-1dc1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 310
LYS A  37
GLU A  23
 None
 1.01A 3ijdB-1dc1A:
2.4		 3ijdB-1dc1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 6 ALA A  53
ILE A 111
LEU A  62
ALA A  71
 None
 0.91A 3r9sA-1dc1A:
undetectable		 3r9sA-1dc1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 145
LEU A 198
LEU A 142
LEU A 316
ILE A 213
 None
 1.16A 3wdmD-1dc1A:
undetectable		 3wdmD-1dc1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 114
SER A  76
LEU A  49
ASN A  96
 None
 1.13A 4n09B-1dc1A:
undetectable		 4n09B-1dc1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 7 SER A 304
GLY A 281
ALA A 282
THR A  19
 None
 0.76A 4r1zB-1dc1A:
0.0		 4r1zB-1dc1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 9 SER A  54
ALA A  56
LEU A 114
LEU A  72
 None
 0.99A 4xtaA-1dc1A:
0.9		 4xtaA-1dc1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 146
LEU A 150
ILE A 320
LEU A 215
 None
 0.79A 4zvcA-1dc1A:
1.8
4zvcB-1dc1A:
1.7		 4zvcA-1dc1A:
17.41
4zvcB-1dc1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 320
LEU A 215
ILE A 146
LEU A 150
 None
 0.79A 4zvcA-1dc1A:
1.8
4zvcB-1dc1A:
1.7		 4zvcA-1dc1A:
17.41
4zvcB-1dc1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 320
GLY A 239
LEU A 301
LEU A 296
 None
 0.84A 5hs1A-1dc1A:
undetectable		 5hs1A-1dc1A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 136
GLY A 243
LYS A 242
GLY A 186
ASP A 212
 DIO  A1002 (-3.6A)
None
None
None
None
 1.01A 5wwsB-1dc1A:
undetectable		 5wwsB-1dc1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1dc1 BSOBI RESTRICTION
ENDONUCLEASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 204
LEU A 206
LEU A 261
GLY A 239
VAL A 211
 None
 1.13A 6eu9B-1dc1A:
1.7		 6eu9B-1dc1A:
13.31