SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dce'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 8 VAL A 285
LEU A 304
SER A 258
VAL A 259
 None
 1.11A 1jtvA-1dceA:
undetectable		 1jtvA-1dceA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		3 / 3 ASP A 225
SER A 227
ARG A 141
 None
 0.68A 3loqA-1dceA:
0.0		 3loqA-1dceA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 5 VAL A 501
LEU A 529
ILE A 526
ASN A 543
 None
 0.97A 4a9kB-1dceA:
3.2		 4a9kB-1dceA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		3 / 3 LEU A 430
GLU A 432
SER A 434
 None
 0.71A 4ccqA-1dceA:
undetectable		 4ccqA-1dceA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 7 GLU A 339
GLU A 254
GLU A 489
ARG A 534
 None
 1.12A 4mi4B-1dceA:
0.0
4mi4C-1dceA:
undetectable		 4mi4B-1dceA:
15.44
4mi4C-1dceA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 8 GLU A 339
GLU A 254
GLU A 489
ARG A 534
 None
 1.12A 4mj8B-1dceA:
0.0
4mj8C-1dceA:
0.0		 4mj8B-1dceA:
14.54
4mj8C-1dceA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 6 THR A 387
LEU A 208
LEU A 356
GLU A 355
 None
 1.21A 4nc3A-1dceA:
3.2		 4nc3A-1dceA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 10 GLY A 503
VAL A 501
VAL A 504
LEU A 456
LEU A 513
 None
 1.17A 4yb6B-1dceA:
undetectable
4yb6C-1dceA:
undetectable		 4yb6B-1dceA:
20.70
4yb6C-1dceA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 10 GLY A 503
VAL A 501
VAL A 504
LEU A 456
LEU A 513
 None
 1.24A 4yb6C-1dceA:
undetectable
4yb6F-1dceA:
undetectable		 4yb6C-1dceA:
20.70
4yb6F-1dceA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 10 LEU A 456
LEU A 513
GLY A 503
VAL A 501
VAL A 504
 None
 1.25A 4yb6A-1dceA:
undetectable
4yb6D-1dceA:
undetectable		 4yb6A-1dceA:
20.70
4yb6D-1dceA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 10 LEU A 456
LEU A 513
GLY A 503
VAL A 501
VAL A 504
 None
 1.22A 4yb6D-1dceA:
undetectable
4yb6E-1dceA:
undetectable		 4yb6D-1dceA:
20.70
4yb6E-1dceA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 8 LEU A 470
LEU A 456
LEU A 459
LEU A 485
LEU A 468
 None
 1.09A 4z90A-1dceA:
3.6
4z90B-1dceA:
3.4
4z90C-1dceA:
4.2
4z90D-1dceA:
3.4
4z90E-1dceA:
3.9		 4z90A-1dceA:
20.36
4z90B-1dceA:
20.36
4z90C-1dceA:
20.36
4z90D-1dceA:
20.36
4z90E-1dceA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 8 LEU A 485
LEU A 468
LEU A 470
LEU A 456
LEU A 459
 None
 1.12A 4z90A-1dceA:
3.6
4z90B-1dceA:
3.4
4z90C-1dceA:
4.2
4z90D-1dceA:
3.4
4z90E-1dceA:
3.9		 4z90A-1dceA:
20.36
4z90B-1dceA:
20.36
4z90C-1dceA:
20.36
4z90D-1dceA:
20.36
4z90E-1dceA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		4 / 4 ASN A 496
LEU A 498
SER A 494
LEU A 513
 None
 1.29A 5kb5A-1dceA:
0.0		 5kb5A-1dceA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		5 / 12 ALA A 524
GLU A 557
LEU A 559
ILE A 565
CYH A 546
 None
 1.15A 5vlmA-1dceA:
2.0		 5vlmA-1dceA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		3 / 3 VAL A 215
TYR A 231
GLU A 367
 None
 0.77A 5zmqD-1dceA:
0.0
5zmqE-1dceA:
undetectable		 5zmqD-1dceA:
14.03
5zmqE-1dceA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)
(Rattus
norvegicus) 		3 / 3 LEU A 462
ASN A 473
LEU A 478
 None
 0.70A 6exiA-1dceA:
undetectable		 6exiA-1dceA:
10.38