SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 6 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.84A 1rs7B-1dciA:
0.1		 1rs7B-1dciA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 5 ILE A 183
ILE A  95
ILE A 263
LEU A 177
 None
 0.83A 1zgyA-1dciA:
undetectable		 1zgyA-1dciA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 12 ILE A 178
GLY A 174
ASP A 198
VAL A 197
SER A 239
 None
 1.24A 1zq9A-1dciA:
undetectable		 1zq9A-1dciA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 10 ILE A 166
ALA A 190
GLN A 188
ALA A 233
ILE A 163
 None
 1.06A 2aclC-1dciA:
undetectable		 2aclC-1dciA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 11 ALA A 190
MET A 112
PHE A 113
ILE A 178
THR A 187
 None
 1.17A 2blaA-1dciA:
undetectable		 2blaA-1dciA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 12 VAL A 214
LEU A 211
VAL A 175
GLY A 240
LEU A 259
 None
 1.18A 2cbrA-1dciA:
undetectable		 2cbrA-1dciA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 7 LEU A  88
ALA A 180
ALA A 164
PHE A 113
 None
 1.00A 2vcvG-1dciA:
0.0		 2vcvG-1dciA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		3 / 3 VAL A 221
VAL A 175
SER A 179
 None
 0.59A 3n8xB-1dciA:
0.0		 3n8xB-1dciA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 12 ALA A 190
MET A 112
PHE A 113
ILE A 178
THR A 187
 None
 1.19A 3qfxA-1dciA:
undetectable		 3qfxA-1dciA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 12 ALA A 190
MET A 112
PHE A 113
ILE A 178
THR A 187
 None
 1.21A 3qfxB-1dciA:
undetectable		 3qfxB-1dciA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 6 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.85A 4d39B-1dciA:
0.1		 4d39B-1dciA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		3 / 3 PHE A 152
VAL A 205
GLU A 196
 None
EDO  A   1 (-4.6A)
None
 0.83A 4fvqA-1dciA:
0.0		 4fvqA-1dciA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 6 GLY A 172
ILE A 171
GLN A 193
VAL A 199
 None
None
SO4  A  14 (-3.2A)
None
 0.81A 4kcnA-1dciA:
0.0		 4kcnA-1dciA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 7 ASP A 305
THR A 303
PHE A 324
SER A 325
 None
 1.33A 4o4dA-1dciA:
0.0		 4o4dA-1dciA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 8 TYR A 185
ILE A 183
ILE A 163
ALA A 260
 None
 0.96A 4ou1A-1dciA:
undetectable		 4ou1A-1dciA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		3 / 3 CYH A 186
PRO A 247
ASP A 234
 None
 0.97A 4pm5A-1dciA:
0.0		 4pm5A-1dciA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 8 GLU A 223
MET A 232
GLU A 235
ALA A 236
 None
 0.87A 4rjdA-1dciA:
undetectable
4rjdB-1dciA:
undetectable		 4rjdA-1dciA:
14.23
4rjdB-1dciA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 11 PHE A 191
GLY A 172
GLY A 174
GLU A 196
ILE A 117
 None
 1.43A 4zvmA-1dciA:
undetectable
4zvmB-1dciA:
undetectable		 4zvmA-1dciA:
22.38
4zvmB-1dciA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		4 / 7 LEU A  71
GLN A  70
PHE A 113
LEU A 177
 None
 1.00A 5b3sP-1dciA:
undetectable		 5b3sP-1dciA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 6 SER A  56
GLU A  55
GLY A 174
ASP A 176
GLY A 116
 None
SO4  A   9 ( 4.8A)
None
None
None
 1.09A 5cdnA-1dciA:
0.0
5cdnB-1dciA:
undetectable		 5cdnA-1dciA:
20.41
5cdnB-1dciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1dci DIENOYL-COA
ISOMERASE
(Rattus
norvegicus) 		5 / 12 VAL A  69
PHE A  84
ILE A  57
SER A  96
VAL A  89
 None
 1.25A 6gsdA-1dciA:
undetectable		 6gsdA-1dciA:
16.88