SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		3 / 3 MET A 252
LEU A 255
SER A 256
 None
 0.54A 1ee2A-1dcnA:
0.0		 1ee2A-1dcnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		3 / 3 THR A 373
LEU A 377
VAL A 380
 None
 0.66A 1mz9E-1dcnA:
0.3		 1mz9E-1dcnA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 12 LEU A 273
LEU A 275
ALA A 348
ILE A 352
ALA A 259
 None
 1.06A 2bxcA-1dcnA:
2.1		 2bxcA-1dcnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 6 ARG A  35
TRP A  76
GLU A  38
ASN A  94
 None
 1.48A 2ejfB-1dcnA:
undetectable		 2ejfB-1dcnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 11 TYR A 265
THR A 274
LEU A 295
SER A 268
HIS A 178
 None
 1.36A 2idkA-1dcnA:
0.0
2idkB-1dcnA:
0.0
2idkC-1dcnA:
0.0
2idkD-1dcnA:
0.0		 2idkA-1dcnA:
20.18
2idkB-1dcnA:
20.18
2idkC-1dcnA:
20.18
2idkD-1dcnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 8 TYR A 265
SER A 177
HIS A 178
LYS A 257
 None
 1.25A 2vmyA-1dcnA:
undetectable
2vmyB-1dcnA:
undetectable		 2vmyA-1dcnA:
23.11
2vmyB-1dcnA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 12 LEU A 123
VAL A 338
ILE A 196
LEU A 131
PHE A 244
 None
 1.07A 3fl9B-1dcnA:
undetectable		 3fl9B-1dcnA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 10 LEU A 123
VAL A 338
ILE A 196
LEU A 131
PHE A 244
 None
 1.10A 3fl9F-1dcnA:
undetectable		 3fl9F-1dcnA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 12 LEU A  36
HIS A  91
GLN A 328
ASP A 122
THR A 121
 None
 1.28A 3g1uB-1dcnA:
undetectable		 3g1uB-1dcnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 6 SER A 302
LEU A 138
ILE A 298
ALA A 248
 None
 0.85A 3kk6B-1dcnA:
0.0		 3kk6B-1dcnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 8 LEU A 273
LEU A 295
ILE A 352
VAL A 351
LEU A 275
 None
 1.24A 3kp6A-1dcnA:
0.0
3kp6B-1dcnA:
0.0		 3kp6A-1dcnA:
17.70
3kp6B-1dcnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 6 ILE A 352
VAL A 351
LEU A 275
LEU A 273
 None
 0.92A 3kp6A-1dcnA:
0.0
3kp6B-1dcnA:
0.0		 3kp6A-1dcnA:
17.70
3kp6B-1dcnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 6 PHE A 240
MET A 127
ARG A 238
VAL A 119
 None
 1.30A 4mk4B-1dcnA:
undetectable		 4mk4B-1dcnA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 5 LEU A 182
SER A 177
LEU A 457
LEU A 141
 None
 1.29A 4n09D-1dcnA:
undetectable		 4n09D-1dcnA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 5 LEU A 201
GLU A 221
LEU A 109
HIS A  91
 None
 1.12A 4xi3B-1dcnA:
1.0		 4xi3B-1dcnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		4 / 7 PHE A 432
ALA A 365
PRO A 168
LEU A 157
 None
 1.10A 5dzkD-1dcnA:
undetectable
5dzkR-1dcnA:
undetectable		 5dzkD-1dcnA:
19.09
5dzkR-1dcnA:
1.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 8 PHE A 432
ALA A 365
PRO A 168
MET A 370
LEU A 157
 None
 1.37A 5dzkd-1dcnA:
undetectable
5dzkr-1dcnA:
undetectable		 5dzkd-1dcnA:
19.09
5dzkr-1dcnA:
1.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 12 VAL A 192
GLY A 190
SER A 186
PHE A 247
VAL A 338
 None
 1.15A 6a94A-1dcnA:
4.5		 6a94A-1dcnA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1dcn DELTA 2 CRYSTALLIN
(Anas
platyrhynchos) 		5 / 12 VAL A 192
GLY A 190
SER A 186
PHE A 247
VAL A 338
 None
 1.18A 6a94B-1dcnA:
0.9		 6a94B-1dcnA:
23.37