SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 CYH A 287
ASP A 266
CYH A 264
GLY A 268
 ZN  A 600 (-2.2A)
None
ZN  A 600 (-2.3A)
None
 0.99A 1ekjA-1dcqA:
undetectable
1ekjB-1dcqA:
undetectable		 1ekjA-1dcqA:
22.79
1ekjB-1dcqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 11 GLU A 250
ILE A 251
GLU A 516
LEU A 429
LEU A 315
 None
 1.18A 1mrqA-1dcqA:
undetectable		 1mrqA-1dcqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 ASN A 278
HIS A 291
VAL A 255
LEU A 282
THR A 283
 None
 1.04A 1oq5A-1dcqA:
undetectable		 1oq5A-1dcqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.45A 1pcgB-1dcqA:
undetectable		 1pcgB-1dcqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 5 ILE A 387
SER A 312
LEU A 316
ASN A 319
 None
 0.95A 1y0xX-1dcqA:
0.0		 1y0xX-1dcqA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 5 GLY A 389
GLN A 392
VAL A 398
SER A 377
 None
 1.28A 1zzuB-1dcqA:
0.0		 1zzuB-1dcqA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 7 VAL A 513
SER A 312
ARG A 470
LEU A 469
 None
 1.00A 2f78A-1dcqA:
undetectable		 2f78A-1dcqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 7 VAL A 513
SER A 312
ARG A 470
LEU A 469
 None
 0.96A 2f78B-1dcqA:
undetectable		 2f78B-1dcqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 6 VAL A 513
SER A 312
ARG A 470
LEU A 469
 None
 1.03A 2f8dA-1dcqA:
0.0		 2f8dA-1dcqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 ASP A 266
PHE A 325
ASN A 326
PHE A 434
GLY A 321
 None
 1.38A 2fqyA-1dcqA:
undetectable		 2fqyA-1dcqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 LEU A 468
ILE A 477
SER A 423
LEU A 419
VAL A 382
 None
 1.10A 2po7A-1dcqA:
undetectable		 2po7A-1dcqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 LEU A 468
ILE A 477
SER A 423
LEU A 419
VAL A 382
 None
 1.08A 2po7B-1dcqA:
undetectable		 2po7B-1dcqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 9 SER A 423
LEU A 390
SER A 428
ILE A 387
GLY A 471
 None
 1.23A 3cv9A-1dcqA:
0.0		 3cv9A-1dcqA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		3 / 3 ASP A 307
LEU A 309
GLN A 437
 None
 0.71A 3g4lA-1dcqA:
undetectable		 3g4lA-1dcqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 ILE A 320
SER A 276
GLY A 280
ASN A 322
 None
 0.80A 3lslA-1dcqA:
undetectable
3lslD-1dcqA:
undetectable		 3lslA-1dcqA:
20.07
3lslD-1dcqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 ILE A 320
SER A 276
GLY A 280
ASN A 326
 None
 0.92A 3lslA-1dcqA:
undetectable
3lslD-1dcqA:
undetectable		 3lslA-1dcqA:
20.07
3lslD-1dcqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 ASN A 322
ILE A 320
SER A 276
GLY A 280
 None
 0.84A 3lslA-1dcqA:
undetectable
3lslD-1dcqA:
undetectable		 3lslA-1dcqA:
20.07
3lslD-1dcqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 ASN A 326
ILE A 320
SER A 276
GLY A 280
 None
 0.91A 3lslA-1dcqA:
undetectable
3lslD-1dcqA:
undetectable		 3lslA-1dcqA:
20.07
3lslD-1dcqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 ALA A 473
LEU A 465
THR A 484
ILE A 488
LEU A 501
 None
 1.21A 3nrrA-1dcqA:
undetectable		 3nrrA-1dcqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 8 ASN A 261
GLY A 260
ASP A 271
GLY A 268
THR A 283
 None
 1.35A 3so9A-1dcqA:
undetectable		 3so9A-1dcqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 CYH A 287
ASP A 266
CYH A 264
GLY A 268
ALA A 269
 ZN  A 600 (-2.2A)
None
ZN  A 600 (-2.3A)
None
ZN  A 600 ( 4.4A)
 1.18A 3ucjA-1dcqA:
undetectable		 3ucjA-1dcqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 CYH A 287
ASP A 266
CYH A 264
GLY A 268
ALA A 269
 ZN  A 600 (-2.2A)
None
ZN  A 600 (-2.3A)
None
ZN  A 600 ( 4.4A)
 1.14A 3ucjB-1dcqA:
undetectable		 3ucjB-1dcqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 5 LYS A 466
LEU A 467
GLU A 463
LEU A 429
 None
 1.16A 4k4yA-1dcqA:
0.0		 4k4yA-1dcqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 4 LYS A 466
LEU A 467
GLU A 463
LEU A 429
 None
 1.17A 4k4yE-1dcqA:
0.0		 4k4yE-1dcqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 5 LYS A 466
LEU A 467
GLU A 463
LEU A 429
 None
 1.19A 4k4yI-1dcqA:
0.0		 4k4yI-1dcqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 11 THR A 446
THR A 415
THR A 401
SER A 450
ALA A 452
 None
 1.47A 4qvyV-1dcqA:
0.0
4qvyb-1dcqA:
undetectable		 4qvyV-1dcqA:
23.13
4qvyb-1dcqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 11 THR A 446
THR A 415
THR A 401
SER A 450
ALA A 452
 None
 1.47A 4qvyH-1dcqA:
undetectable
4qvyN-1dcqA:
undetectable		 4qvyH-1dcqA:
23.13
4qvyN-1dcqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		4 / 8 ILE A 387
LEU A 378
ILE A 404
PHE A 434
 None
 0.89A 4r38D-1dcqA:
0.0		 4r38D-1dcqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.38A 5dxbA-1dcqA:
0.0		 5dxbA-1dcqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.41A 5dxeB-1dcqA:
undetectable		 5dxeB-1dcqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 9 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.41A 5dxgA-1dcqA:
0.0		 5dxgA-1dcqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 10 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.34A 5hyrA-1dcqA:
0.0		 5hyrA-1dcqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 11 THR A 446
THR A 415
THR A 401
SER A 450
ALA A 452
 None
 1.49A 5l5fV-1dcqA:
undetectable
5l5fb-1dcqA:
undetectable		 5l5fV-1dcqA:
23.13
5l5fb-1dcqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 11 THR A 446
THR A 415
THR A 401
SER A 450
ALA A 452
 None
 1.48A 5l5fH-1dcqA:
0.0
5l5fN-1dcqA:
undetectable		 5l5fH-1dcqA:
23.13
5l5fN-1dcqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 VAL A 382
LEU A 442
LEU A 417
ALA A 420
SER A 423
 None
 1.23A 5nd3B-1dcqA:
undetectable		 5nd3B-1dcqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1dcq PYK2-ASSOCIATED
PROTEIN BETA
(Mus
musculus) 		5 / 12 VAL A 382
LEU A 417
ALA A 420
SER A 423
LEU A 429
 None
 1.19A 5nd7B-1dcqA:
undetectable		 5nd7B-1dcqA:
20.94