SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 9 LEU A 163
LEU A 136
GLU A   8
ILE A 139
GLN A 161
 None
ACY  A 280 ( 4.7A)
None
None
None
 1.47A 1gx8A-1dd5A:
undetectable		 1gx8A-1dd5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 12 ILE A  78
LEU A  65
ARG A  28
LEU A  87
ILE A  40
 None
 1.06A 2drcB-1dd5A:
undetectable		 2drcB-1dd5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		4 / 6 SER A  73
TYR A  44
VAL A  42
ASP A  71
 None
 1.48A 2x45A-1dd5A:
undetectable		 2x45A-1dd5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		4 / 6 ARG A 129
ILE A  20
LEU A  24
GLU A 119
 None
 0.97A 2ya7A-1dd5A:
0.0		 2ya7A-1dd5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		4 / 6 ARG A 129
ILE A  20
LEU A  24
GLU A 119
 None
 0.94A 2ya7B-1dd5A:
undetectable		 2ya7B-1dd5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		4 / 6 ARG A 129
ILE A  20
LEU A  24
GLU A 119
 None
 0.95A 2ya7D-1dd5A:
undetectable		 2ya7D-1dd5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		4 / 8 VAL A 121
GLY A 124
LYS A 125
LYS A 116
 None
 0.97A 3bjwA-1dd5A:
2.1		 3bjwA-1dd5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 9 ILE A 160
ILE A 139
LYS A 138
GLU A   8
LYS A  12
 None
 0.81A 3f78A-1dd5A:
undetectable		 3f78A-1dd5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 9 ILE A 160
ILE A 139
LYS A 138
GLU A   8
LYS A  12
 None
 0.89A 3f78B-1dd5A:
undetectable		 3f78B-1dd5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 12 ILE A  78
LEU A  65
ARG A  28
LEU A  87
ILE A  40
 None
 1.01A 4ej1A-1dd5A:
undetectable		 4ej1A-1dd5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1dd5 RIBOSOME RECYCLING
FACTOR
(Thermotoga
maritima) 		5 / 12 VAL A  51
ILE A  78
SER A  58
VAL A  97
ILE A  98
 None
 1.41A 6gsdA-1dd5A:
undetectable		 6gsdA-1dd5A:
20.11