SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ddk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 208
PRO A 162
LEU A 205
 None
 0.54A 1hrkA-1ddkA:
undetectable		 1hrkA-1ddkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 117
ASN A 116
GLN A 113
THR A 102
 None
 1.08A 1ig3A-1ddkA:
0.0
1ig3B-1ddkA:
0.0		 1ig3A-1ddkA:
21.69
1ig3B-1ddkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 8 ILE A  47
ILE A 130
GLU A 131
VAL A 132
ILE A  74
 None
 1.20A 1linA-1ddkA:
undetectable		 1linA-1ddkA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.09A 1p7lC-1ddkA:
undetectable		 1p7lC-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.08A 1p7lD-1ddkA:
undetectable		 1p7lD-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.08A 1rg9A-1ddkA:
undetectable		 1rg9A-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.05A 1rg9B-1ddkA:
undetectable		 1rg9B-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.06A 1rg9C-1ddkA:
undetectable		 1rg9C-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
LYS A  33
SER A  21
THR A  52
 ZN  A 501 ( 3.4A)
None
None
None
 1.05A 1rg9D-1ddkA:
undetectable		 1rg9D-1ddkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  84
HIS A  79
ILE A  86
SER A  76
 None
ZN  A 500 (-3.4A)
None
None
 0.81A 1utdB-1ddkA:
0.0
1utdC-1ddkA:
0.0		 1utdB-1ddkA:
17.04
1utdC-1ddkA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A  52
SER A  21
ASP A  55
VAL A  31
 None
 1.17A 2hdnI-1ddkA:
undetectable
2hdnJ-1ddkA:
undetectable
2hdnL-1ddkA:
undetectable		 2hdnI-1ddkA:
11.70
2hdnJ-1ddkA:
20.59
2hdnL-1ddkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  31
THR A  52
SER A  21
ASP A  55
 None
 1.18A 2hdnJ-1ddkA:
undetectable
2hdnK-1ddkA:
0.0
2hdnL-1ddkA:
undetectable		 2hdnJ-1ddkA:
20.59
2hdnK-1ddkA:
11.70
2hdnL-1ddkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 179
HIS A  77
ASP A 109
 None
ZN  A 500 (-3.4A)
None
 0.72A 2oxtA-1ddkA:
undetectable		 2oxtA-1ddkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.18A 2zj0A-1ddkA:
2.5		 2zj0A-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.15A 2zj0B-1ddkA:
3.1		 2zj0B-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.13A 2zj0C-1ddkA:
2.7		 2zj0C-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 3ce6A-1ddkA:
2.6		 3ce6A-1ddkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 3ce6B-1ddkA:
2.9		 3ce6B-1ddkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 3ce6C-1ddkA:
2.3		 3ce6C-1ddkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 170
ILE A 160
GLY A 156
ASN A 167
LEU A 165
 None
None
None
ACY  A 510 (-4.4A)
None
 1.15A 3eeyC-1ddkA:
undetectable		 3eeyC-1ddkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.11A 3g1uA-1ddkA:
2.8		 3g1uA-1ddkA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.12A 3g1uC-1ddkA:
2.6		 3g1uC-1ddkA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.15A 3glqA-1ddkA:
3.2		 3glqA-1ddkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.13A 3glqB-1ddkA:
2.6		 3glqB-1ddkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 168
THR A 209
ALA A 213
ALA A 175
ALA A 171
 None
 0.99A 3mdvB-1ddkA:
0.0		 3mdvB-1ddkA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.12A 3n58A-1ddkA:
3.0		 3n58A-1ddkA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 9 HIS A  79
ASP A  81
HIS A 139
CYH A 158
ASN A 167
HIS A 197
 ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.37A 4c1dA-1ddkA:
31.4		 4c1dA-1ddkA:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		7 / 10 HIS A  77
HIS A  79
ASP A  81
HIS A 139
CYH A 158
ASN A 167
HIS A 197
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.40A 4c1dB-1ddkA:
31.4		 4c1dB-1ddkA:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		8 / 11 VAL A  25
HIS A  77
HIS A  79
ASP A  81
HIS A 139
CYH A 158
LYS A 161
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 4.5A)
ZN  A 501 ( 3.4A)
 0.50A 4c1fA-1ddkA:
40.4
4c1fB-1ddkA:
39.3		 4c1fA-1ddkA:
100.00
4c1fB-1ddkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  25
HIS A  79
LYS A 161
ASN A 167
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 501 ( 4.5A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.86A 4c1fA-1ddkA:
40.4
4c1fB-1ddkA:
39.3		 4c1fA-1ddkA:
100.00
4c1fB-1ddkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		7 / 9 HIS A  77
HIS A  79
ASP A  81
HIS A 139
CYH A 158
GLY A 166
HIS A 197
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
None
ZN  A 501 ( 3.4A)
 0.69A 4c1hA-1ddkA:
30.9		 4c1hA-1ddkA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A  96
ALA A 114
LEU A 106
SER A  73
ILE A  47
 None
 1.48A 4claA-1ddkA:
0.0		 4claA-1ddkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 9 VAL A  31
HIS A  79
ASP A  81
HIS A 139
CYH A 158
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 3.4A)
 0.38A 4exsA-1ddkA:
30.3		 4exsA-1ddkA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		7 / 8 VAL A  31
HIS A  79
ASP A  81
HIS A 139
CYH A 158
ASN A 167
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.61A 4exsB-1ddkA:
30.5		 4exsB-1ddkA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  81
ASP A  48
HIS A  77
SER A  82
 ZN  A 501 ( 2.7A)
None
ZN  A 500 (-3.4A)
None
 1.20A 4k7gB-1ddkA:
0.0		 4k7gB-1ddkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 4lvcA-1ddkA:
2.7		 4lvcA-1ddkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 4lvcC-1ddkA:
2.7		 4lvcC-1ddkA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  31
HIS A  77
CYH A 158
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 3.4A)
 0.92A 5a5zA-1ddkA:
31.0		 5a5zA-1ddkA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		7 / 8 VAL A  31
HIS A  79
ASP A  81
HIS A 139
CYH A 158
ASN A 167
HIS A 197
 None
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.34A 5a5zA-1ddkA:
31.0		 5a5zA-1ddkA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 7 HIS A 139
CYH A 158
LYS A 161
GLY A 166
ASN A 167
HIS A 197
 ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 4.5A)
None
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.58A 5a5zC-1ddkA:
30.9		 5a5zC-1ddkA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  77
HIS A  79
ASP A  81
HIS A 139
HIS A 197
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 3.4A)
 0.90A 5ayaA-1ddkA:
17.1		 5ayaA-1ddkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  46
ILE A  47
GLY A  72
ILE A 130
 None
 0.85A 5dzk3-1ddkA:
undetectable
5dzkm-1ddkA:
undetectable		 5dzk3-1ddkA:
1.90
5dzkm-1ddkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  47
GLY A  72
ILE A 130
LEU A  46
 None
 0.86A 5dzkB-1ddkA:
undetectable
5dzkI-1ddkA:
undetectable
5dzkW-1ddkA:
undetectable		 5dzkB-1ddkA:
22.41
5dzkI-1ddkA:
23.17
5dzkW-1ddkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 ILE A  47
GLY A  72
ILE A 130
LEU A  46
 None
 0.88A 5dzkl-1ddkA:
undetectable
5dzkz-1ddkA:
undetectable		 5dzkl-1ddkA:
23.17
5dzkz-1ddkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 114
ILE A  74
GLY A  72
ILE A  94
PRO A  50
 None
 1.26A 5kr2A-1ddkA:
undetectable		 5kr2A-1ddkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 114
ILE A  74
GLY A  72
ILE A  94
PRO A  50
 None
 1.23A 5kr2C-1ddkA:
undetectable		 5kr2C-1ddkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 197
HIS A 139
HIS A  77
SER A  82
 ZN  A 501 ( 3.4A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
 1.02A 5m8rA-1ddkA:
undetectable		 5m8rA-1ddkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 197
HIS A 139
HIS A  77
SER A  82
 ZN  A 501 ( 3.4A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
 1.02A 5m8rB-1ddkA:
undetectable		 5m8rB-1ddkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 193
ILE A 160
PHE A 159
GLY A 188
ALA A 190
 None
 1.18A 5mxbA-1ddkA:
0.2		 5mxbA-1ddkA:
15.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 8 HIS A  79
ASP A  81
HIS A 139
CYH A 158
ASN A 167
HIS A 197
 ZN  A 500 (-3.4A)
ZN  A 501 ( 2.7A)
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
 0.49A 5zj8A-1ddkA:
14.9		 5zj8A-1ddkA:
33.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.13A 6aphA-1ddkA:
3.0		 6aphA-1ddkA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.18A 6f3nA-1ddkA:
3.1		 6f3nA-1ddkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.18A 6f3nC-1ddkA:
3.1		 6f3nC-1ddkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.18A 6f3nD-1ddkA:
2.8		 6f3nD-1ddkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 6gbnA-1ddkA:
2.8		 6gbnA-1ddkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 6gbnB-1ddkA:
2.6		 6gbnB-1ddkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.14A 6gbnC-1ddkA:
2.8		 6gbnC-1ddkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1ddk IMP-1 METALLO
BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.15A 6gbnD-1ddkA:
2.5		 6gbnD-1ddkA:
20.00