SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1deu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		3 / 4 VAL A 184
TRP A   5
TRP A 196
 None
 1.33A 1gmkC-1deuA:
undetectable
1gmkD-1deuA:
undetectable		 1gmkC-1deuA:
6.34
1gmkD-1deuA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 5 SER A 217
THR A 218
GLU A 232
GLY A 137
 None
 1.32A 1icrA-1deuA:
0.0
1icrB-1deuA:
0.0		 1icrA-1deuA:
18.53
1icrB-1deuA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 5 GLU A 232
GLY A 137
SER A 217
THR A 218
 None
 1.34A 1icrA-1deuA:
0.0
1icrB-1deuA:
0.0		 1icrA-1deuA:
18.53
1icrB-1deuA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 5 SER A 217
THR A 218
GLU A 232
GLY A 137
 None
 1.29A 1icvC-1deuA:
0.0
1icvD-1deuA:
0.0		 1icvC-1deuA:
18.53
1icvD-1deuA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 5 GLU A 232
GLY A 137
SER A 217
THR A 218
 None
 1.32A 1kqbA-1deuA:
0.0
1kqbB-1deuA:
0.0		 1kqbA-1deuA:
20.71
1kqbB-1deuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 7 ILE A 151
GLU A 139
LEU A   1
GLY A 149
 None
 0.89A 1mt1H-1deuA:
undetectable
1mt1K-1deuA:
undetectable		 1mt1H-1deuA:
15.81
1mt1K-1deuA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 10 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.27A 1t3rA-1deuA:
undetectable		 1t3rA-1deuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 10 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.32A 1t7iA-1deuA:
undetectable		 1t7iA-1deuA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 11 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.22A 1t7jA-1deuA:
undetectable		 1t7jA-1deuA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		5 / 12 ALA A 185
GLY A 186
ALA A  16
ILE A 151
SER A 183
 None
 1.14A 1ve3B-1deuA:
undetectable		 1ve3B-1deuA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.28A 2idwB-1deuA:
undetectable		 2idwB-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 7 TRP A 202
TYR A 169
GLU A 208
TYR A 164
 None
 1.29A 2xytD-1deuA:
undetectable		 2xytD-1deuA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 7 GLN A  22
GLY A  29
HIS A 180
TRP A 202
 None
 0.31A 3ai8A-1deuA:
26.9		 3ai8A-1deuA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		5 / 12 PHE A 237
GLY A 149
GLY A 186
ALA A 185
VAL A 184
 None
 1.04A 3av6A-1deuA:
undetectable		 3av6A-1deuA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 10 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.27A 3ekvA-1deuA:
undetectable		 3ekvA-1deuA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 11 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.27A 3nu3B-1deuA:
undetectable		 3nu3B-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.28A 3nu4B-1deuA:
undetectable		 3nu4B-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.26A 3nujB-1deuA:
undetectable		 3nujB-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.26A 3nuoB-1deuA:
undetectable		 3nuoB-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 10 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.29A 3oy4B-1deuA:
undetectable		 3oy4B-1deuA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		4 / 8 LEU A 126
GLN A 108
TYR A 124
TYR A  82
 None
 1.27A 3po7A-1deuA:
undetectable		 3po7A-1deuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		5 / 8 GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.14A 3so9A-1deuA:
0.0		 3so9A-1deuA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		3 / 3 TRP A   7
VAL A 184
TRP A   5
 None
 1.33A 3zq8A-1deuA:
undetectable
3zq8B-1deuA:
undetectable		 3zq8A-1deuA:
6.34
3zq8B-1deuA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 10 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.27A 4dqhB-1deuA:
undetectable		 4dqhB-1deuA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 12 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.28A 4jecA-1deuA:
0.0		 4jecA-1deuA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.30A 4q1wA-1deuA:
undetectable		 4q1wA-1deuA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.26A 4rvjB-1deuA:
undetectable		 4rvjB-1deuA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.25A 4rvjD-1deuA:
undetectable		 4rvjD-1deuA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1deu PROCATHEPSIN X
(Homo
sapiens) 		3 / 3 SER A 136
LEU A   1
MET A 142
 None
 0.87A 5ikrB-1deuA:
0.0		 5ikrB-1deuA:
17.72