SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		3 / 3 LYS A 220
ILE A 129
THR A   1
 None
 0.68A 1rx3A-1dexA:
1.1		 1rx3A-1dexA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 5 ALA A  45
ALA A 158
ALA A 159
VAL A 128
 None
 0.89A 2nyrB-1dexA:
2.7		 2nyrB-1dexA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		5 / 12 LEU A  27
MET A  11
TYR A  48
VAL A  35
ILE A  68
 None
 1.35A 3frqA-1dexA:
0.0		 3frqA-1dexA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		3 / 3 LYS A 220
ILE A 129
THR A   1
 None
 0.65A 4gh8A-1dexA:
0.9		 4gh8A-1dexA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 8 ASN A  37
ALA A  12
ARG A  43
TYR A  48
 None
 0.96A 4ijiF-1dexA:
0.0		 4ijiF-1dexA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		3 / 3 ASP A 192
TRP A 170
SER A   9
 None
 0.98A 4lrhA-1dexA:
0.0		 4lrhA-1dexA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		5 / 10 GLY A 125
PHE A 121
LEU A 120
ALA A  58
ASP A  59
 None
 1.30A 4wnuD-1dexA:
undetectable		 4wnuD-1dexA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 8 LEU A  27
THR A 224
LEU A 223
LEU A  31
 None
 0.71A 4z90F-1dexA:
0.0
4z90G-1dexA:
0.0
4z90H-1dexA:
0.0
4z90I-1dexA:
0.0
4z90J-1dexA:
0.0		 4z90F-1dexA:
20.85
4z90G-1dexA:
20.85
4z90H-1dexA:
20.85
4z90I-1dexA:
20.85
4z90J-1dexA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 7 ASP A 192
ILE A 191
GLY A  17
THR A 194
 None
 0.97A 4zxiA-1dexA:
3.8		 4zxiA-1dexA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 6 SER A  98
ARG A  50
GLU A 105
TYR A 100
 None
 1.26A 5x7pB-1dexA:
undetectable		 5x7pB-1dexA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 6 SER A  98
ARG A  50
GLU A 105
TYR A 100
 None
 1.30A 5x7qA-1dexA:
undetectable		 5x7qA-1dexA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 6 SER A  98
ARG A  50
GLU A 105
TYR A 100
 None
 1.29A 5x7qB-1dexA:
undetectable		 5x7qB-1dexA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 6 SER A  98
ARG A  50
GLU A 105
TYR A 100
 None
 1.30A 5x7rA-1dexA:
1.2		 5x7rA-1dexA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dex RHAMNOGALACTURONAN
ACETYLESTERASE
(Aspergillus
aculeatus) 		4 / 6 SER A  98
ARG A  50
GLU A 105
TYR A 100
 None
 1.29A 5x7rB-1dexA:
undetectable		 5x7rB-1dexA:
11.56