SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
GLU A 113
HIS A  68
HIS A  74
 FE  A 132 (-3.4A)
None
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.18A 1uttA-1dfxA:
undetectable		 1uttA-1dfxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
GLU A 113
HIS A  68
HIS A  74
 FE  A 132 (-3.4A)
None
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.19A 1utzB-1dfxA:
undetectable		 1utzB-1dfxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
HIS A 118
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.37A 2fqfA-1dfxA:
undetectable		 2fqfA-1dfxA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
HIS A 118
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.33A 2fqgA-1dfxA:
undetectable		 2fqgA-1dfxA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
GLU A 113
HIS A  68
HIS A  74
 FE  A 132 (-3.4A)
None
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.19A 2ozrE-1dfxA:
undetectable		 2ozrE-1dfxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
GLU A 113
HIS A  68
HIS A  74
 FE  A 132 (-3.4A)
None
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.22A 3lilA-1dfxA:
undetectable		 3lilA-1dfxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
HIS A 118
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.37A 4ef3A-1dfxA:
undetectable		 4ef3A-1dfxA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 7 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.85A 4ze3A-1dfxA:
undetectable		 4ze3A-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 8 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.90A 5eseA-1dfxA:
0.0		 5eseA-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 8 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.93A 5esfA-1dfxA:
0.0		 5esfA-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 8 TYR A   7
ILE A  15
GLY A 119
THR A  41
 None
 0.87A 5esjA-1dfxA:
0.0		 5esjA-1dfxA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A  74
CYH A 115
HIS A  68
HIS A  48
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.46A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 4 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.26A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdB-1dfxA:
undetectable		 5zrdB-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdB-1dfxA:
undetectable		 5zrdB-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.23A 5zrdC-1dfxA:
2.4		 5zrdC-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.28A 5zrdC-1dfxA:
2.4		 5zrdC-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.17A 5zrdD-1dfxA:
2.3		 5zrdD-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1dfx DESULFOFERRODOXIN
(Desulfovibrio
desulfuricans) 		4 / 5 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdD-1dfxA:
2.3		 5zrdD-1dfxA:
12.66