SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)
(Homo
sapiens) 		4 / 7 PHE A 275
LEU A 174
LEU A 164
LEU A 169
 None
 0.64A 3bgdB-1dg6A:
undetectable		 3bgdB-1dg6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)
(Homo
sapiens) 		5 / 12 PHE A 248
LEU A 167
VAL A 122
ILE A 256
MET A 223
 None
 0.96A 3gwxB-1dg6A:
undetectable		 3gwxB-1dg6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)
(Homo
sapiens) 		3 / 3 ILE A 126
SER A 186
SER A 273
 None
 0.53A 3iltH-1dg6A:
undetectable		 3iltH-1dg6A:
20.45